Product image of Nocedan (Levocetirizine Dihydrochloride) supplied by GNH India

Nocedan

Active Ingredient:
Levocetirizine Dihydrochloride
Origin:
EU

Nocedan (Levocetirizine Dihydrochloride)

Levocetirizine dihydrochloride, the active ingredient in Nocedan, is an antihistamine presented as an oral tablet for oral use. It alleviates symptoms of allergic rhinitis and chronic idiopathic urticaria in adults and children when prescribed.

GNH India supplies Nocedan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches to meet global demand. Our distribution network ensures timely delivery and reliable product traceability across multiple continents worldwide.

Manufacturer / TM Owner

Avansor Pharma Oy

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Indications & Clinical Uses

  • Levocetirizine is an antihistamine that reduces histamine‑mediated symptoms in allergic conditions.
  • Allergic rhinitis: relief of nasal congestion, sneezing, itching and rhinorrhea.
  • Seasonal allergic rhinitis: symptom control during pollen‑driven allergy periods.
  • Chronic idiopathic urticaria: reduction of wheal formation and itching.

How It Works

  • Levocetirizine dihydrochloride selectively blocks peripheral histamine H1 receptors, preventing histamine from binding to mast cells and other target tissues. By inhibiting this receptor interaction, it diminishes the vascular permeability, nerve stimulation and smooth‑muscle contraction that underlie the clinical manifestations of allergic reactions. The drug’s high affinity for the H1 site provides rapid onset of symptom relief with minimal central nervous system penetration.

Side Effects

Levocetirizine may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Drowsiness: mild sedation.
  • Dry mouth: reduced salivation.
  • Headache: mild cranial pain.
  • Nausea: upset stomach.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips or throat.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Anaphylaxis: rapid, life‑threatening allergic response.

Precautions & Warnings

Before initiating levocetirizine therapy, certain precautions should be considered to ensure safe use.

  • Assess renal function: dose adjustment may be needed in severe renal impairment.
  • Avoid in known hypersensitivity: discontinue if allergic reaction occurs.
  • Caution with hepatic impairment: monitor liver function tests.
  • Monitor sedation: advise patients not to operate machinery if drowsiness occurs.
  • Pregnancy and lactation: use only if clearly needed after medical evaluation.
  • Store at room temperature: keep in the original container, protect from moisture.

Avoid Interactions

Levocetirizine can interact with other medicines, altering its effectiveness or safety profile.

Major Interactions (Avoid)

  • Ketoconazole: may increase levocetirizine plasma concentrations.
  • Erythromycin: can raise systemic exposure leading to heightened side effects.
  • Ritonavir: strong CYP3A4 inhibition may elevate drug levels.

Moderate Interactions (Monitor Closely)

  • Alcohol: additive central nervous system depression may increase drowsiness.
  • Other CNS depressants: such as benzodiazepines, may enhance sedation.
  • Theophylline: may reduce antihistaminic effect.

Frequently Asked Questions

Nocedan contains levocetirizine dihydrochloride, an antihistamine indicated for the relief of symptoms associated with allergic rhinitis and chronic idiopathic urticaria. It helps reduce nasal congestion, sneezing, itching, and skin hives when prescribed by a qualified healthcare professional.

Levocetirizine works by selectively blocking peripheral histamine H1 receptors. This antagonism prevents histamine from triggering the cascade that leads to vasodilation, increased vascular permeability, and nerve stimulation, thereby alleviating the typical signs of an allergic response.

The appropriate dose of Nocedan is determined by the prescribing clinician based on the patient’s age, condition severity, and renal function. In most adult cases, a single daily dose is common, but exact dosing instructions must be obtained from a qualified prescriber.

Safety data for levocetirizine in pregnancy and lactation are limited. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made in consultation with a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity of Nocedan. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levocetirizine is the active enantiomer of cetirizine, offering similar efficacy with a potentially lower incidence of sedation. Compared with first‑generation antihistamines, it provides more selective H1 blockade and fewer anticholinergic side effects, making it a preferred option for many patients with allergic conditions.

Nocedan tablets should be stored at room temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and avoid storing in areas with high humidity or extreme temperatures.

Nocedan is taken orally, usually as a whole tablet swallowed with a glass of water. It can be taken with or without food, but patients should follow the specific instructions provided by their prescriber to ensure optimal absorption.

Serious adverse reactions, although rare, include angioedema (swelling of the face, lips or throat), severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis, and anaphylaxis. Patients should seek immediate medical attention if they experience any of these symptoms.

Nocedan should be avoided in individuals with known hypersensitivity to levocetirizine or any excipients in the tablet. Caution is also advised for patients with severe renal impairment, and it is not recommended for children below the age specified in the prescribing information without medical guidance.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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