Product image of Noctis (Doxylamine Hydrogen Succinate) supplied by GNH India

Noctis

Active Ingredient:
Doxylamine Hydrogen Succinate
Origin:
EU

Noctis (Doxylamine Hydrogen Succinate)

Doxylamine hydrogen succinate, the active ingredient in Noctis, is a antihistamine presented as an oral dosage form for oral use. It provides short‑term relief of insomnia and helps alleviate symptoms of allergic rhinitis and the common cold.

GNH India supplies Noctis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Biofarm Sp. Z O.O.

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Indications & Clinical Uses

Doxylamine hydrogen succinate acts on histamine H1 receptors to produce sedative and antiallergic effects, making it useful for several common conditions.

  • Insomnia: short‑term assistance in falling asleep and maintaining sleep.
  • Allergic rhinitis: reduction of nasal congestion, itching, and sneezing.
  • Common cold: relief of runny nose, cough and sleep disturbance associated with cold symptoms.

How It Works

  • Doxylamine hydrogen succinate is a selective antagonist of histamine H1 receptors in the central nervous system and peripheral tissues. By blocking H1 receptors, it reduces histamine‑mediated wakefulness and allergic responses, producing sedative, anticholinergic, and antihistaminic effects that facilitate sleep and alleviate nasal and respiratory symptoms.

Side Effects

Adverse reactions may occur with doxylamine use and should be monitored.

Common Side Effects

  • Drowsiness
  • Dry mouth
  • Dizziness
  • Headache

Serious or Rare Side Effects

  • Anaphylaxis (severe allergic reaction)
  • Cardiac arrhythmia
  • Severe skin rash such as Stevens‑Johnson syndrome

Precautions & Warnings

Use of Noctis requires attention to several safety considerations.

  • Children under 12 years: avoid use unless specifically prescribed.
  • Elderly patients: start with the lowest effective dose and monitor for anticholinergic effects.
  • Concomitant CNS depressants: avoid or use with caution due to additive sedation.
  • Pregnancy and breastfeeding: safety not established; consult a healthcare professional.
  • Known hypersensitivity: do not use if allergic to doxylamine or related compounds.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Doxylamine may interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Alcohol: can intensify sedation and respiratory depression.
  • Central nervous system depressants (e.g., benzodiazepines, opioids): risk of profound drowsiness.
  • Monoamine oxidase inhibitors (MAOIs): may increase anticholinergic effects.

Moderate Interactions (Monitor Closely)

  • Anticholinergic drugs (e.g., atropine, tricyclic antidepressants): additive anticholinergic burden.
  • Selective serotonin reuptake inhibitors (SSRIs): monitor for increased sedation.
  • Antihypertensive agents: possible enhancement of blood pressure‑lowering effect.

Frequently Asked Questions

Noctis contains doxylamine hydrogen succinate and is indicated for short‑term treatment of insomnia, relief of allergic rhinitis symptoms such as nasal congestion and sneezing, and alleviation of common cold symptoms that interfere with sleep.

Doxylamine hydrogen succinate blocks histamine H1 receptors in the brain and peripheral tissues. This antagonism reduces histamine‑driven wakefulness and allergic inflammation, producing a sedative effect and decreasing nasal and respiratory symptoms.

The appropriate dose of Noctis is determined by the prescribing healthcare professional based on the individual’s age, condition, and response. Typical adult dosing for insomnia is a single dose taken at bedtime, but exact amounts should follow the prescriber’s instructions.

Safety of doxylamine hydrogen succinate in pregnancy and lactation has not been definitively established. Women who are pregnant, planning pregnancy, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Noctis.

To order Noctis, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The most common alternative to doxylamine is diphenhydramine, another first‑generation antihistamine. Both provide sedation and antiallergic effects, but doxylamine often has a slightly longer half‑life, which may result in more sustained sleep support. Side‑effect profiles are similar, though individual tolerance can vary.

Noctis should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiry date printed on the label.

Noctis is taken orally, usually with a glass of water. For insomnia, it is generally taken shortly before bedtime. If used for allergic rhinitis or cold symptoms, it can be taken with or without food as directed by a healthcare professional.

Serious risks include severe allergic reactions such as anaphylaxis, cardiac arrhythmias, and rare but severe skin reactions like Stevens‑Johnson syndrome. If any signs of these conditions appear—such as difficulty breathing, rapid heartbeat, or widespread rash—seek immediate medical attention.

Noctis should be avoided by individuals with known hypersensitivity to doxylamine or other first‑generation antihistamines, children under 12 years of age unless specifically prescribed, pregnant or breastfeeding women without medical advice, and patients with severe hepatic impairment or uncontrolled narrow‑angle glaucoma.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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