Product image of Noctis Forte (Doxylamine Hydrogen Succinate) supplied by GNH India

Noctis Forte

Active Ingredient:
Doxylamine Hydrogen Succinate
Origin:
EU

Noctis Forte (Doxylamine Hydrogen Succinate)

Doxylamine hydrogen succinate, the active ingredient in Noctis Forte, is a first‑generation antihistamine presented as an oral tablet for oral use. It provides short‑term relief of insomnia and alleviates symptoms of allergic rhinitis and the common cold in adults, acting through antihistaminic and anticholinergic mechanisms.

GNH India supplies Noctis Forte as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Biofarm Sp. Z O.O.

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Indications & Clinical Uses

Doxylamine hydrogen succinate works on histamine H1 receptors to manage several common conditions.

  • Insomnia: helps initiate and maintain sleep during short‑term use in adults.
  • Allergic rhinitis: reduces nasal congestion, sneezing, and itching caused by seasonal allergies.
  • Common cold: eases runny nose and sneezing associated with upper respiratory infections.
  • Nausea in pregnancy (off‑label): may lessen morning sickness when prescribed by a healthcare professional.

How It Works

  • Doxylamine hydrogen succinate acts as a competitive antagonist at histamine H1 receptors, blocking the action of endogenous histamine. This inhibition produces antihistaminic effects, while its anticholinergic activity contributes to sedation and reduced secretions. The combined actions result in decreased allergy symptoms and a sedative effect that can facilitate sleep.

Side Effects

Adverse reactions may occur with doxylamine use and vary in frequency.

Common Side Effects

  • Drowsiness: feeling unusually sleepy or fatigued.
  • Dry mouth: reduced salivation leading to a parched sensation.
  • Dizziness: light‑headed feeling, especially when standing quickly.
  • Blurred vision: temporary difficulty focusing.
  • Constipation: slowed intestinal motility.
  • Urinary retention: difficulty emptying the bladder.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction with rash, swelling, and breathing difficulty.
  • Cardiac arrhythmia: irregular heart rhythm, potentially life‑threatening.
  • Seizures: convulsive episodes in susceptible individuals.
  • Hallucinations: visual or auditory disturbances.
  • Severe confusion or delirium, particularly in the elderly.
  • Respiratory depression when combined with other CNS depressants.

Precautions & Warnings

Before using Noctis Forte, consider the following safety measures.

  • Use as directed: follow the prescriber's instructions and do not exceed recommended duration.
  • Avoid operating machinery: sedation may impair alertness and reaction time.
  • Caution in elderly: increased sensitivity to anticholinergic effects may raise fall risk.
  • Alcohol and CNS depressants: avoid concurrent use to prevent excessive sedation.
  • Contraindicated in narrow‑angle glaucoma: anticholinergic activity can worsen intra‑ocular pressure.
  • Pregnancy safety unknown: discuss risks with a healthcare professional before use.
  • Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Doxylamine may interact with other medicines, altering its effectiveness or safety.

Major Interactions (Avoid)

  • Alcohol or other CNS depressants: can cause profound sedation and respiratory depression.
  • Benzodiazepines: additive sedative effects increase risk of oversedation.
  • MAO inhibitors: may enhance anticholinergic and hypertensive reactions.
  • Other antihistamines: combined use raises risk of anticholinergic toxicity.
  • QT‑prolonging drugs: potential for cardiac arrhythmias.

Moderate Interactions (Monitor Closely)

  • CYP2D6 inhibitors (e.g., fluoxetine): may increase doxylamine plasma levels.
  • SSRIs or SNRIs: monitor for enhanced serotonergic side effects.
  • Antihypertensive agents: anticholinergic effect may blunt blood pressure control.

Frequently Asked Questions

Noctis Forte contains doxylamine hydrogen succinate, an oral antihistamine used as a short‑term sleep aid and to relieve symptoms of allergic rhinitis and the common cold, such as runny nose and sneezing. It may also be prescribed off‑label for nausea associated with pregnancy.

Doxylamine hydrogen succinate blocks histamine H1 receptors, preventing histamine from triggering allergy symptoms. Its anticholinergic activity also depresses central nervous system activity, producing a sedative effect that helps initiate sleep.

The appropriate dose of Noctis Forte is determined by a qualified healthcare professional based on the individual’s condition, age, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

The safety of doxylamine hydrogen succinate in pregnancy and lactation has not been definitively established. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Noctis Forte.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Compared with newer non‑benzodiazepine hypnotics, doxylamine is a first‑generation antihistamine that may cause more anticholinergic side effects such as dry mouth and drowsiness. However, it is widely available OTC, inexpensive, and effective for occasional short‑term insomnia, making it a practical option for many patients.

Noctis Forte should be stored below 25 °C in a dry environment. Keep the tablets in their original packaging to protect them from moisture and light, and keep out of reach of children.

Noctis Forte is taken orally, usually with a glass of water. It is generally recommended to take the tablet shortly before bedtime for insomnia, or as directed for allergy or cold symptom relief. Swallow the tablet whole; do not crush or chew unless instructed by a healthcare professional.

Serious risks include severe allergic reactions such as anaphylaxis, cardiac arrhythmias, seizures, and profound sedation that can impair breathing, especially when combined with alcohol or other CNS depressants. Patients should seek immediate medical attention if they experience symptoms like difficulty breathing, rapid heartbeat, or severe confusion.

Individuals with known hypersensitivity to doxylamine or other first‑generation antihistamines, those with narrow‑angle glaucoma, severe urinary retention, or significant gastrointestinal obstruction should avoid Noctis Forte. It is also contraindicated in patients taking monoamine oxidase inhibitors or who require high‑precision alertness, such as drivers or machine operators.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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