Noctofer (Lormetazepam)

Lormetazepam binds to the benzodiazepine site on the GABA‑A receptor, increasing the receptor’s affinity for the inhibitory neurotransmitter GABA. This amplifies chloride ion flow into neurons, hyper‑polarising them and reducing neuronal excitability, which produces sedative and hypnotic effects.

The appropriate dose of Noctofer is determined by the prescribing clinician based on the patient’s age, medical condition, and response to therapy. Dosage instructions are provided on the prescription label and should be followed exactly as directed by the healthcare professional.

Safety of lormetazepam in pregnancy or lactation has not been fully established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To order Noctofer, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Compared with non‑benzodiazepine hypnotics, lormetazepam has a rapid onset and a relatively short elimination half‑life, which may reduce next‑day residual effects. However, like all benzodiazepines, it carries a higher risk of dependence and should be limited to short‑term use.

Store Noctofer at ambient temperature, below 25 °C, in the original container. Protect the tablets from moisture, light and excessive heat to maintain potency. Keep out of reach of children and do not use after the expiry date printed on the package.

Noctofer is taken orally, usually once nightly, shortly before bedtime. The tablet should be swallowed whole with a glass of water and not chewed or crushed, unless otherwise instructed by a healthcare professional.

Serious risks include respiratory depression, especially when combined with other central nervous system depressants, and the potential for physical dependence, tolerance and withdrawal symptoms after prolonged use. Rarely, severe allergic reactions such as rash or angioedema may occur.

Noctofer should be avoided in patients with known hypersensitivity to lormetazepam or other benzodiazepines, in individuals with severe respiratory insufficiency, and in those with a history of substance misuse. Caution is also advised for the elderly, pregnant women and patients with significant hepatic or renal impairment.