Product image of Nocutil (Desmopressin Acetate) supplied by GNH India

Nocutil

Active Ingredient:
Desmopressin Acetate
Origin:
EU

Nocutil (Desmopressin Acetate)

Desmopressin Acetate, the active ingredient in Nocutil, is a vasopressin V2 receptor agonist presented as an oral tablet for oral use. It is used to manage central diabetes insipidus, nocturnal enuresis, hemophilia A and von Willebrand disease in appropriate patients.
GNH India supplies Nocutil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Gebro Pharma Gmbh

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Indications & Clinical Uses

Desmopressin acetate acts on the vasopressin V2 receptor pathway to control water balance and coagulation factors.

  • Central diabetes insipidus: reduces excessive urine output by enhancing renal water reabsorption.
  • Nocturnal enuresis: decreases nighttime bedwetting by concentrating urine.
  • Hemophilia A: raises plasma factor VIII levels to improve clot formation.
  • Von Willebrand disease: elevates von Willebrand factor, aiding platelet adhesion and clot stability.

How It Works

  • Desmopressin acetate selectively stimulates V2 receptors on renal collecting‑duct cells, promoting insertion of aquaporin‑2 water channels and increasing water reabsorption. The same V2 activation in endothelial cells triggers release of stored factor VIII and von Willebrand factor, enhancing hemostasis. These actions are dose‑dependent and reversible upon discontinuation.

Side Effects

Desmopressin acetate may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Hyponatremia: mild reduction in serum sodium levels.
  • Headache: transient, often resolves without treatment.
  • Nausea or abdominal cramps: gastrointestinal discomfort.
  • Facial flushing or mild nasal congestion: temporary vascular effects.

Serious or Rare Side Effects

  • Severe hyponatremia leading to seizures or coma.
  • Water intoxication with cerebral edema.
  • Allergic reactions such as rash, pruritus or anaphylaxis.
  • Thrombotic events in patients with pre‑existing clotting disorders.

Precautions & Warnings

Desmopressin acetate requires careful monitoring in several clinical situations.

  • Fluid intake: limit excessive water consumption to reduce hyponatremia risk.
  • Serum sodium: check baseline and periodic sodium levels, especially in the elderly.
  • Renal function: adjust use in patients with impaired kidney function.
  • Concomitant drugs: avoid simultaneous use with vasopressin antagonists or strong diuretics without supervision.
  • Pregnancy: safety not established; use only if benefits outweigh potential risks.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Desmopressin acetate can interact with several medicines that affect water balance or coagulation.

Major Interactions (Avoid)

  • Vasopressin antagonists (e.g., conivaptan, tolvaptan): block therapeutic effect.
  • Carbamazepine: accelerates desmopressin metabolism, reducing efficacy.
  • NSAIDs (high‑dose): increase risk of hyponatremia.

Moderate Interactions (Monitor Closely)

  • Diuretics (especially thiazides): may potentiate water retention.
  • Antihypertensives: additive hypotensive effect possible.
  • SSRIs or other serotonergic agents: slight increase in hyponatremia risk.

Frequently Asked Questions

Nocutil, containing desmopressin acetate, is prescribed for central diabetes insipidus, nocturnal enuresis, hemophilia A and von Willebrand disease. In each case the drug helps either by concentrating urine or by raising clotting factor levels, providing symptom control and improving quality of life.

Desmopressin acetate is a selective V2 vasopressin receptor agonist. It binds to V2 receptors in the kidney, promoting aquaporin‑2 channel insertion and increasing water reabsorption. The same receptor activation in endothelial cells triggers release of factor VIII and von Willebrand factor, supporting hemostasis.

The dosage of Nocutil is individualized by the prescribing clinician based on the specific indication, patient age, weight and renal function. Only a qualified healthcare professional should determine the appropriate strength and frequency of administration.

Safety data for desmopressin acetate in pregnancy and lactation are limited. It should be used only if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by the treating physician.

To request Nocutil, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Compared with traditional antidiuretic hormones, desmopressin acetate has a longer half‑life and a more selective V2‑receptor profile, resulting in fewer vasoconstrictive side effects. It is also preferred over some synthetic analogues because it can raise clotting factors, offering a dual benefit in bleeding disorders.

Nocutil should be stored at ambient temperature, ideally below 25 °C. Keep the tablets in their original container, protect them from moisture and direct sunlight, and avoid storing them in bathrooms or other humid environments.

Nocutil is taken orally as a tablet. The patient should swallow the tablet whole with water, following the dosing schedule prescribed by the healthcare provider. It is not intended for sublingual or crushed administration.

The most critical safety concerns are severe hyponatremia and water intoxication, which can lead to seizures, cerebral edema, or coma. Patients should be monitored for signs of low sodium and advised to limit excessive fluid intake.

Nocutil is contraindicated in patients with known hypersensitivity to desmopressin acetate, uncontrolled hyponatremia, or those receiving vasopressin antagonists. Caution is also advised for individuals with severe renal impairment or active thrombotic disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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