Nocutil Melt (Desmopressin Acetate)

Desmopressin acetate mimics the natural hormone vasopressin. It binds primarily to V2 receptors in the kidney, promoting water reabsorption, and to V1 receptors on endothelial cells, stimulating the release of factor VIII and von Willebrand factor, which improves haemostasis.

The dose of Nocutil Melt is individualized by the prescribing clinician based on the patient’s condition, age, renal function and response to therapy. No standard dosing regimen is provided here; the prescriber will set the appropriate amount and frequency.

Safety data for desmopressin acetate in pregnancy and lactation are limited. The product’s pregnancy category is not established, and clinicians usually weigh potential benefits against unknown risks before prescribing to pregnant or nursing women.

To request Nocutil Melt, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Desmopressin acetate is a synthetic vasopressin analogue with greater selectivity for V2 receptors, offering a longer duration of action and fewer vasoconstrictive effects than natural vasopressin (Pitressin). This makes it preferable for chronic management of diabetes insipidus and for haemostatic use.

Store Nocutil Melt at room temperature, below 25 °C, in its original container. Protect the product from moisture, excessive heat and direct sunlight to maintain stability and potency.

Nocutil Melt is given sublingually. The tablet or melt is placed under the tongue and allowed to dissolve completely without swallowing until it is fully absorbed, ensuring rapid onset of action.

The most critical safety concerns are severe hyponatraemia and water intoxication, which can lead to seizures, cerebral oedema, or coma. Patients should be monitored for rapid weight gain, confusion, headache or vomiting, which may signal dangerous electrolyte shifts.

Nocutil Melt is contraindicated in patients with existing hyponatraemia, uncontrolled hypertension, severe renal impairment, or known hypersensitivity to desmopressin. Caution is also advised for individuals with a history of water‑retention disorders or those taking interacting medications that increase the risk of low sodium.