Product image of Nogest (Nomegestrol Acetate) supplied by GNH India

Nogest

Active Ingredient:
Nomegestrol Acetate
Origin:
EU

Nogest (Nomegestrol Acetate)

Nomegestrol acetate, the active ingredient in Nogest, is a synthetic progestogen presented as an oral tablet for oral use. It is employed to prevent pregnancy and to provide progestogenic support in menopausal hormone therapy, acting on women of reproductive age and those requiring hormonal balance during menopause and is approved for use in the European Union.

GNH India supplies Nogest as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality, regulatory compliance and reliable logistics for global health partners.

Manufacturer / TM Owner

Ceres Pharma Nv

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Nomegestrol acetate in Nogest is used in hormonal pathways to prevent pregnancy and to manage menopausal symptoms.

  • Oral contraception: prevents ovulation and pregnancy in women of reproductive age by providing progestogenic activity.
  • Menopausal hormone therapy: alleviates vasomotor symptoms and supports endometrial stability during estrogen‑containing regimens.
  • Cycle control: regulates menstrual bleeding patterns and reduces irregular spotting in women with hormonal imbalances.

How It Works

  • Nomegestrol acetate is a synthetic progestogen that binds with high affinity to progesterone receptors in the hypothalamic‑pituitary‑ovarian axis. Receptor activation suppresses the luteinizing hormone surge, inhibiting ovulation, and induces endometrial transformation that renders the uterine lining unsuitable for implantation. In menopausal therapy it provides progestogenic support to counterbalance estrogen effects and maintain hormonal balance.

Side Effects

Nomegestrol acetate may be associated with a range of adverse reactions, varying in frequency and severity.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Headache: tension‑type or migraine‑like pain.
  • Breast tenderness: discomfort or swelling of breast tissue.
  • Weight gain: modest increase in body weight.
  • Irregular bleeding: spotting or changes in menstrual flow.

Serious or Rare Side Effects

  • Venous thromboembolism: deep vein thrombosis or pulmonary embolism.
  • Liver dysfunction: elevated enzymes or hepatitis.
  • Allergic reactions: rash, itching, swelling, or anaphylaxis.

Precautions & Warnings

Before prescribing Nogest, clinicians should evaluate several safety considerations to minimize risk.

  • Pregnancy: contraindicated in known or suspected pregnancy.
  • Breastfeeding: avoid unless benefits outweigh potential risks to the infant.
  • Smoking: caution in women over 35 who smoke due to increased thrombotic risk.
  • History of thromboembolism: not recommended for patients with prior clotting events.
  • Drug interactions: review concomitant medications that may affect efficacy or safety.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Nomegestrol acetate can interact with other medicines, altering its effectiveness or safety profile.

Major Interactions (Avoid)

  • Combined hormonal contraceptives containing estrogen: may increase risk of thromboembolism.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): can raise plasma levels of nomegestrol acetate.
  • Enzyme‑inducing antiepileptics (e.g., carbamazepine, phenytoin): may reduce contraceptive efficacy.

Moderate Interactions (Monitor Closely)

  • Rifampicin and other potent inducers: may diminish hormonal activity.
  • St. John’s wort: may lower drug concentrations.
  • Certain antibiotics (e.g., clarithromycin): may modestly increase exposure.

Frequently Asked Questions

Nogest contains nomegestrol acetate, a synthetic progestogen used primarily as an oral contraceptive to prevent pregnancy and as part of menopausal hormone therapy to relieve vasomotor symptoms and provide endometrial protection when combined with estrogen.

Nomegestrol acetate binds to progesterone receptors in the hypothalamic‑pituitary‑ovarian axis, suppressing the luteinizing hormone surge and thereby inhibiting ovulation. It also induces changes in the endometrium that make it unsuitable for implantation and, in menopausal regimens, balances estrogen effects.

The specific dose and regimen of Nogest are determined by the prescribing healthcare professional based on the individual’s medical history, indication, and local regulatory guidelines. Patients should follow the prescriber’s instructions and not alter the dose on their own.

Nogest is contraindicated during known or suspected pregnancy because it is intended to prevent conception. Use while breastfeeding is generally discouraged unless the benefits to the mother clearly outweigh potential risks to the infant; a healthcare provider should evaluate each case.

To order Nogest, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Compared with many combined oral contraceptives that contain both estrogen and a progestin, Nogest provides a progestogen‑only option, which may be preferred for women who cannot tolerate estrogen. Its synthetic progestogen, nomegestrol acetate, offers strong receptor affinity and a favorable bleeding profile, though individual response varies.

Nogest tablets should be stored at ambient temperature, below 25 °C, in the original blister pack or container. Protect them from excess moisture, heat and direct sunlight to maintain potency throughout the shelf life.

Nogest is taken orally, usually once daily at the same time each day, as directed by the prescriber. For contraceptive use, a typical cycle consists of 21 days of active tablets followed by a hormone‑free interval, but the exact schedule should follow the healthcare professional’s guidance.

The most serious adverse events associated with Nogest include venous thromboembolism (deep‑vein thrombosis or pulmonary embolism), severe liver dysfunction, and allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience unexplained leg pain, shortness of breath, jaundice, or signs of a severe allergic response.

Nogest should not be used by women who are pregnant, have a known hypersensitivity to nomegestrol acetate, have a history of thromboembolic disorders, uncontrolled hypertension, active liver disease, or who are smokers over the age of 35. A thorough medical assessment by a qualified clinician is essential before initiation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.