Product image of Nogest (Nomegestrol Acetate) supplied by GNH India

Nogest

Active Ingredient:
Nomegestrol Acetate
Origin:
EU

Nogest (Nomegestrol Acetate)

Nomegestrol acetate, the active ingredient in Nogest, is a progestogen presented as an oral tablet for oral use. It is employed as a hormonal contraceptive and as a progestogenic component in hormone replacement therapy for women of reproductive age and post‑menopausal patients.

GNH India supplies Nogest as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ceres Pharma Nv

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Nomegestrol acetate is used in hormonal regimens that modulate the progesterone pathway.

  • Oral contraception: prevents pregnancy by suppressing ovulation and altering cervical mucus.
  • Hormone replacement therapy: provides progestogenic support to estrogen therapy in menopausal women.
  • Endometrial protection: reduces the risk of estrogen‑induced endometrial hyperplasia during combined hormone replacement therapy.

How It Works

  • Nomegestrol acetate acts as a selective progesterone receptor agonist. By binding to progesterone receptors in the hypothalamus and pituitary, it inhibits the luteinizing hormone surge, thereby suppressing ovulation. In the endometrium, it induces a secretory transformation that opposes estrogen‑driven proliferation, creating an environment unsuitable for implantation and supporting hormonal balance in replacement therapy.

Side Effects

Adverse reactions may occur with any hormonal agent.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Headache: tension‑type or migraine‑like pain.
  • Breast tenderness: discomfort or swelling of the breasts.
  • Irregular bleeding: spotting or changes in menstrual flow.

Serious or Rare Side Effects

  • Venous thromboembolism: deep vein thrombosis or pulmonary embolism.
  • Hepatic dysfunction: abnormal liver enzymes or jaundice.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Assess thrombotic risk: evaluate personal or family history of clotting disorders.
  • Screen for liver disease: avoid use in severe hepatic impairment.
  • Monitor blood pressure: watch for new or worsening hypertension.
  • Avoid in pregnancy: contraindicated unless benefits outweigh risks.
  • Store at ambient temperature: keep below 25°C in the original pack, protect from moisture.

Avoid Interactions

Nomegestrol acetate may interact with several drug classes.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampicin): may markedly reduce contraceptive efficacy.
  • Anticoagulants (warfarin): potential alteration of anticoagulant effect.
  • Antiepileptic drugs (carbamazepine): may diminish plasma concentrations.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (ketoconazole): may increase plasma levels.
  • Antiretrovirals (ritonavir): can affect metabolism and efficacy.
  • Herbal supplements (St. John’s wort): may lower effectiveness of the contraceptive.

Frequently Asked Questions

Nogest contains nomegestrol acetate, a progestogen used primarily as a hormonal contraceptive to prevent pregnancy and as a progestogenic component in hormone replacement therapy to manage menopausal symptoms and protect the endometrium.

Nomegestrol acetate binds selectively to progesterone receptors, inhibiting the luteinizing hormone surge and thereby suppressing ovulation. In the uterus, it induces a secretory endometrium that counteracts estrogen‑driven proliferation, supporting contraceptive and replacement therapy goals.

The specific dose and regimen of Nogest are determined by the prescribing healthcare professional based on the patient’s clinical situation, regulatory guidelines, and therapeutic objectives. Patients should follow the prescriber’s instructions exactly.

Nogest is contraindicated during pregnancy because it can affect fetal development. Its safety during breastfeeding has not been established; therefore, use is generally avoided unless the benefits to the mother clearly outweigh potential risks to the infant.

To request Nogest, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with older progestogens, nomegestrol acetate offers a high receptor selectivity, which may result in a more favorable bleeding profile and lower androgenic activity. However, efficacy and safety are comparable, and the choice depends on individual patient factors and clinician preference.

Nogest tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original blister pack, protect from moisture and direct sunlight, and keep out of reach of children.

Nogest is taken orally, usually once daily at the same time each day, as directed by the prescriber. Swallow the tablet whole with water; do not crush or chew unless specifically instructed.

The most serious risks include venous thromboembolism, hepatic dysfunction, and severe allergic reactions. Patients should seek immediate medical attention if they experience symptoms such as unexplained leg swelling, jaundice, or signs of anaphylaxis.

Nogest should not be used by women with a history of thromboembolic disorders, severe liver disease, uncontrolled hypertension, known hypersensitivity to nomegestrol acetate, or those who are currently pregnant. A thorough medical assessment is essential before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.