Product image of Nogreg (Clopidogrel) supplied by GNH India

Nogreg

Active Ingredient:
Clopidogrel
Origin:
EU

Nogreg (Clopidogrel)

Clopidogrel, the active ingredient in Nogreg, is a P2Y12 receptor antagonist presented as a tablet for oral use. It reduces platelet aggregation to prevent thrombotic events in patients with atherosclerotic disease, acute coronary syndrome, recent myocardial infarction, ischemic stroke, and peripheral arterial disease.

GNH India supplies Nogreg as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

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Indications & Clinical Uses

Clopidogrel is an antiplatelet agent used to reduce thrombotic risk in atherosclerotic cardiovascular disease.

  • Atherosclerotic disease: prevents thrombotic events in patients with coronary or peripheral artery disease.
  • Acute coronary syndrome: reduces risk of recurrent ischemic events.
  • Recent myocardial infarction: lowers incidence of subsequent cardiovascular events.
  • Ischemic stroke: helps prevent recurrent stroke.
  • Peripheral arterial disease: decreases risk of limb ischemia.

How It Works

  • Clopidogrel irreversibly binds to the platelet P2Y12 ADP receptor, blocking ADP‑mediated activation of the glycoprotein IIb/IIIa complex. This inhibition prevents platelet shape change, granule release, and aggregation, thereby reducing thrombus formation in arterial circulation.

Side Effects

Clopidogrel may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Bleeding gums
  • Easy bruising
  • Nausea
  • Diarrhea
  • Headache

Serious or Rare Side Effects

  • Severe bleeding (intracranial or gastrointestinal)
  • Thrombotic thrombocytopenic purpura (TTP)
  • Allergic reactions such as rash or angioedema
  • Elevated liver enzymes

Precautions & Warnings

Before prescribing Clopidogrel, clinicians should consider several safety aspects.

  • Assess bleeding risk: evaluate history of hemorrhage before initiating therapy.
  • Monitor platelet function: periodic labs may be required in high‑risk patients.
  • Avoid in active pathological bleeding: discontinue if severe bleeding occurs.
  • Caution with hepatic impairment: dose adjustment may be needed.
  • Pregnancy and lactation: safety not established; use only if benefit outweighs risk.
  • Store at ambient temperature: keep below 25°C in original packaging, protect from moisture.

Avoid Interactions

Clopidogrel interacts with several drug classes that can alter its efficacy or safety.

Major Interactions (Avoid)

  • Concurrent use with strong CYP2C19 inhibitors (e.g., omeprazole, fluconazole): may reduce antiplatelet effect.
  • Combination with other antithrombotic agents (e.g., warfarin, heparin, direct oral anticoagulants): increased bleeding risk.
  • Use with non‑steroidal anti‑inflammatory drugs (NSAIDs): heightened gastrointestinal bleeding.

Moderate Interactions (Monitor Closely)

  • CYP2C19 inducers (e.g., rifampin, carbamazepine): may decrease efficacy.
  • Proton pump inhibitors (e.g., pantoprazole): potential interaction, monitor clinical response.
  • Selective serotonin reuptake inhibitors (SSRIs): may increase bleeding tendency.

Frequently Asked Questions

Nogreg contains clopidogrel, an antiplatelet medication prescribed to lower the risk of clot‑related events such as heart attacks, strokes, and peripheral arterial disease in patients with atherosclerotic cardiovascular conditions.

Clopidogrel irreversibly blocks the platelet P2Y12 ADP receptor, preventing ADP‑induced platelet activation and aggregation. This inhibition reduces the formation of arterial thrombi that can cause myocardial infarction or stroke.

The exact dose of Nogreg is determined by the prescribing clinician based on the patient’s condition, renal function, and other clinical factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for clopidogrel in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and under close medical supervision.

To order Nogreg, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nogreg (clopidogrel) is a P2Y12 inhibitor, offering a once‑daily oral regimen and a different metabolic pathway compared with aspirin or ticagrelor. It is often chosen for patients who need a potent antiplatelet effect without the twice‑daily dosing required for some alternatives.

Nogreg tablets should be stored at ambient temperature, below 25 °C, in the original container to protect them from moisture and light. Keep the product out of reach of children and do not use after the expiry date.

Nogreg is taken orally, usually with a glass of water. It can be taken with or without food, but patients should follow the specific instructions given by their healthcare provider to ensure optimal absorption.

The most serious risks include severe or life‑threatening bleeding, such as intracranial hemorrhage or gastrointestinal bleeding, and rare events like thrombotic thrombocytopenic purpura (TTP). Patients should seek immediate medical attention if they experience unusual bruising, blood in stool or urine, or neurological symptoms.

Nogreg is contraindicated in patients with active pathological bleeding, a history of severe hypersensitivity to clopidogrel or any component of the tablet, and those with severe liver disease. Clinicians should also avoid use in patients who are currently receiving certain strong CYP2C19 inhibitors without careful assessment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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