Nogrip (Pheniramine Maleate, Ascorbic Acid, Paracetamol)

Nogrip combines an antihistamine, a vitamin and an analgesic to address common discomforts of the upper respiratory tract and feverish illnesses.

• Headache: reduces pain intensity and improves tolerance.
• Fever: lowers elevated body temperature associated with infection.
• Mild to moderate pain: alleviates discomfort from musculoskeletal or dental sources.
• Common cold and flu symptoms: eases nasal discharge, itching and general malaise.
• Allergic rhinitis: diminishes rhinorrhea, itching and sneezing.

• Pheniramine maleate blocks peripheral H1 histamine receptors, limiting the cascade that produces allergic symptoms. Paracetamol acts centrally by inhibiting cyclooxygenase enzymes and modulating serotonergic pathways, providing analgesic and antipyretic effects. Ascorbic acid serves as an essential antioxidant, supporting enzymatic reactions and contributing to overall immune function. The three components work synergistically to relieve pain, fever and allergic manifestations.

Common Side Effects

• Drowsiness: mild sedation may occur, especially after the first dose.
• Dry mouth: reduced salivation leading to a feeling of thirst.
• Nausea or stomach upset: transient gastrointestinal discomfort.
• Headache: occasional rebound headache in susceptible individuals.
• Skin rash: mild erythema or itching at the site of contact.
• Dizziness: transient light‑headedness, particularly when standing quickly.

Serious or Rare Side Effects

• Anaphylaxis: severe allergic reaction with difficulty breathing or swelling.
• Hepatotoxicity: rare liver injury manifested by jaundice or elevated enzymes.
• Blood dyscrasias: uncommon cases of agranulocytosis or thrombocytopenia.
• Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
• Cardiac arrhythmias: very rare, associated with high‑dose pheniramine.
• Persistent vomiting: may indicate a serious gastrointestinal response.

Before using Nogrip, consider the following precautions:

• Pregnancy: consult a healthcare professional before use.
• Breastfeeding: discuss potential risks with a physician.
• Liver disease: monitor hepatic function and use the lowest effective dose.
• Alcohol consumption: avoid or limit alcohol as it may increase sedation and liver load.
• Concomitant antihistamines: use with caution to prevent excessive drowsiness.
• Store at ambient temperature: keep in the original packaging, protect from moisture and direct sunlight.

Nogrip may interact with several medicines; review the following categories.

Major Interactions (Avoid)

• MAO inhibitors: risk of hypertensive crisis when combined with pheniramine.
• Warfarin: paracetamol may enhance anticoagulant effect, increasing bleeding risk.
• Other central nervous system depressants: additive sedation or respiratory depression.
• Alcohol: potentiates drowsiness and liver toxicity.

Moderate Interactions (Monitor Closely)

• CYP450 inducers (e.g., rifampicin): may reduce paracetamol effectiveness.
• Antacids containing aluminum or magnesium: may affect pheniramine absorption.
• Other analgesics (NSAIDs): increase risk of gastrointestinal irritation.
• Diuretics: pheniramine may reduce diuretic efficacy.