Product image of Nolicin (Norfloxacin) supplied by GNH India

Nolicin

Active Ingredient:
Norfloxacin
Origin:
EU

Nolicin (Norfloxacin)

Norfloxacin, the active ingredient in Nolicin, is a fluoroquinolone antibiotic presented as an oral tablet for systemic use. It treats a range of bacterial infections, particularly in the urinary and genitourinary tracts, and is prescribed for adults requiring targeted antimicrobial therapy.

GNH India supplies Nolicin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides reliable sourcing for global healthcare providers.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

Noricin, a fluoroquinolone antibiotic, is employed to manage bacterial infections of specific organ systems.

  • Urinary tract infections: eradicates susceptible uropathogens, relieving symptoms and preventing complications.
  • Prostatitis: eliminates the causative bacteria, reducing inflammation and improving urinary flow.
  • Gonorrhea: treats the infection by targeting Neisseria gonorrhoeae strains.
  • Traveler's diarrhea: combats enteric bacteria responsible for acute diarrheal episodes in travelers.

How It Works

  • Noricin (norfloxacin) inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA supercoiling and replication. By binding to these enzymes, the drug prevents bacterial DNA synthesis and transcription, leading to bactericidal activity against a broad spectrum of Gram‑negative and some Gram‑positive organisms.

Side Effects

Noricin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Diarrhea: loose stools that may be self‑limiting.
  • Headache: transient cranial discomfort.
  • Abdominal pain: cramping or discomfort in the stomach area.

Serious or Rare Side Effects

  • Tendon rupture: sudden tendon pain or rupture, especially in the Achilles.
  • QT interval prolongation: potential cardiac rhythm disturbances.
  • Severe allergic reaction: hives, swelling, or anaphylaxis requiring immediate medical attention.

Precautions & Warnings

When prescribing Noricn, clinicians should consider several safety factors.

  • Renal impairment: dose adjustment may be required to avoid accumulation.
  • History of tendon disorders: avoid use due to increased risk of tendon injury.
  • Concurrent antacids or supplements containing magnesium or aluminum: separate administration by at least two hours.
  • Pregnancy and lactation: use only if potential benefits outweigh known risks.
  • Store at ambient temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Noricin can affect the activity of other medicines; awareness of key interactions helps minimize risk.

Major Interactions (Avoid)

  • Co‑administration with other fluoroquinolones: increased risk of tendon toxicity.
  • Warfarin: enhanced anticoagulant effect, may require INR monitoring.
  • Theophylline: elevated plasma concentrations, risk of toxicity.

Moderate Interactions (Monitor Closely)

  • Antacids containing magnesium or aluminum: reduced norfloxacin absorption; separate dosing.
  • NSAIDs: may increase risk of central nervous system adverse effects.
  • Oral hypoglycemic agents: possible alteration of blood glucose control.

Frequently Asked Questions

Nolicin contains norfloxacin, a fluoroquinolone antibiotic indicated for the treatment of uncomplicated urinary tract infections, prostatitis, gonorrhea and traveler’s diarrhea caused by susceptible bacteria.

Norfloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. This inhibition stops bacterial growth and leads to cell death, providing a bactericidal effect against a broad range of Gram‑negative organisms.

The prescribed dose of Nolicin is set by the treating clinician based on the type and severity of infection, patient age, renal function and any concomitant medications. Dosage regimens are individualized and should follow the prescriber’s instructions.

Safety data for norfloxacin in pregnancy and lactation are limited. It should be used only when the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To request Nolicin, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Noricin (norfloxacin) shares the class‑wide mechanism of DNA gyrase inhibition but differs in its spectrum of activity, pharmacokinetic profile and tissue penetration. Compared with ciprofloxacin, norfloxacin often has a slightly lower oral bioavailability but similar efficacy for urinary infections.

Store Nolicin at ambient temperature, below 25 °C, in the original container. Protect the tablets from moisture, excessive heat and direct sunlight to maintain potency throughout the shelf life.

Nolicin is taken orally, usually with a full glass of water. The tablet should be swallowed whole and not crushed or chewed, unless otherwise directed by a healthcare professional.

Serious risks include tendon rupture or tendinitis, especially in older adults or those on corticosteroids; QT interval prolongation leading to cardiac arrhythmias; and severe hypersensitivity reactions such as anaphylaxis. Prompt medical attention is required if any of these occur.

Nolicin should be avoided in patients with a known hypersensitivity to norfloxacin or other fluoroquinolones, those with a history of tendon disorders related to fluoroquinolone use, and individuals with significant cardiac conduction abnormalities that predispose to QT prolongation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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