Product image of Nolicin (Norfloxacin) supplied by GNH India

Nolicin

Active Ingredient:
Norfloxacin
Origin:
EU

Nolicin (Norfloxacin)

Norfloxacin, the active ingredient in Nolicin, is a fluoroquinolone antibiotic presented as an oral tablet for systemic use. It treats a range of bacterial infections, particularly those affecting the urinary and gastrointestinal tracts, in adult patients as prescribed by a healthcare professional.

GNH India supplies Nolicin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

Noricloxacin is a broad‑spectrum fluoroquinolone that targets bacterial DNA replication, making it useful for several infection types.

  • Uncomplicated urinary tract infection: eradicates susceptible Gram‑negative uropathogens causing cystitis.
  • Acute bacterial prostatitis: penetrates prostatic tissue to treat infection.
  • Traveler’s diarrhea (enteric infections): effective against common enteric pathogens.
  • Gonococcal urethritis: used when alternative agents are unsuitable.
  • Lower respiratory tract infection: treats susceptible organisms in bronchitis or pneumonia.

How It Works

  • Norfloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA supercoiling and replication. By binding to these enzymes, it prevents the unwinding of DNA, halting bacterial replication and transcription, leading to bacterial cell death. This bactericidal action is concentration‑dependent and effective against a wide range of Gram‑negative and some Gram‑positive organisms.

Side Effects

Noricloxacin may cause a variety of adverse reactions, ranging from mild to severe.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: loose stools, sometimes watery.
  • Headache: transient cranial discomfort.
  • Dizziness: occasional light‑headedness.
  • Abdominal pain: cramping or discomfort.
  • Rash: mild skin erythema.

Serious or Rare Side Effects

  • Tendon rupture: especially Achilles, may occur without warning.
  • QT interval prolongation: risk of cardiac arrhythmias.
  • Severe allergic reactions: anaphylaxis, angioedema.
  • Clostridioides difficile infection: colitis due to flora disruption.
  • Photosensitivity: heightened skin reaction to sunlight.
  • Peripheral neuropathy: numbness or tingling in extremities.

Precautions & Warnings

Before prescribing Noricloxacin, clinicians should consider several safety aspects.

  • Assess renal function: dose adjustment may be required in renal impairment.
  • Known hypersensitivity: avoid in patients allergic to fluoroquinolones.
  • Monitor tendon health: discontinue if tendon pain or swelling occurs.
  • Use cautiously in the elderly: increased risk of CNS effects and falls.
  • Avoid concomitant antacids containing aluminum or magnesium: may reduce drug absorption.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Noricloxacin can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Theophylline: increased serum theophylline levels, risk of toxicity.
  • Warfarin: enhanced anticoagulant effect, monitor INR closely.
  • Certain antiarrhythmics (e.g., quinidine): additive QT prolongation risk.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): heightened CNS toxicity.

Moderate Interactions (Monitor Closely)

  • Antacids containing aluminum or magnesium: may decrease norfloxacin absorption.
  • Iron supplements: can bind to the drug and reduce bioavailability.
  • Corticosteroids: may increase risk of tendon disorders.

Frequently Asked Questions

Nolicin, containing the fluoroquinolone norfloxacin, is prescribed for bacterial infections such as uncomplicated urinary tract infections, acute bacterial prostatitis, traveler’s diarrhea caused by enteric pathogens, and certain lower respiratory tract infections when the causative bacteria are susceptible.

Norfloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA supercoiling and replication. By inhibiting these targets, the drug prevents bacterial DNA synthesis, leading to cell death and eradication of the infection.

The dosage of Nolicin is determined by the prescribing clinician based on the type and severity of the infection, patient age, renal function, and other clinical factors. Patients should follow the exact regimen provided by their healthcare professional.

Safety data for norfloxacin in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To order Nolicin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Noricloxacin shares the class‑wide mechanism of DNA gyrase inhibition but differs in its spectrum of activity, pharmacokinetics and tissue penetration. Compared with ciprofloxacin, norfloxacin has similar efficacy for urinary pathogens but may have a slightly different dosing schedule and safety profile, especially regarding tendon‑related risks.

Nolicin should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiry date.

Nolicin is taken orally, usually with a full glass of water. It may be taken with or without food, but patients should avoid simultaneous intake of antacids containing aluminum or magnesium, as these can reduce absorption.

Serious adverse events include tendon rupture, especially of the Achilles tendon, QT interval prolongation leading to cardiac arrhythmias, severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated colitis, and peripheral neuropathy. Patients should seek immediate medical attention if they experience any of these symptoms.

Nolicin is contraindicated in individuals with a known hypersensitivity to norfloxacin or any fluoroquinolone, and it should be avoided in patients with a history of tendon disorders related to fluoroquinolone use. Caution is also advised for those with significant cardiac arrhythmias or prolonged QT interval.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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