Product image of Nolicin (Norfloxacin) supplied by GNH India

Nolicin

Active Ingredient:
Norfloxacin
Origin:
EU

Nolicin (Norfloxacin)

Norfloxacin, the active ingredient in Nolicin, is a fluoroquinolone presented as an oral tablet for systemic use. It is employed to treat bacterial infections of the urinary tract, acute bacterial prostatitis, gastroenteritis and certain respiratory tract infections in adult patients.

GNH India supplies Nolicin as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies and clinics worldwide through regulated distribution channels. The company adheres to stringent quality standards and offers reliable logistics for global markets, ensuring timely delivery.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

Nolicin (norfloxacin) is indicated for bacterial infections affecting several organ systems.

  • Urinary tract infections: eradicates susceptible Gram‑negative and some Gram‑positive pathogens, relieving symptoms and preventing recurrence.
  • Acute bacterial prostatitis: achieves bacterial clearance in the prostate, improving pain and urinary function.
  • Gastroenteritis caused by susceptible bacteria: reduces bacterial load in the intestine, alleviating diarrhea and abdominal discomfort.
  • Respiratory tract infections: treats susceptible strains causing bronchitis or pneumonia, aiding recovery of respiratory function.

How It Works

  • Norfloxacin exerts its antibacterial effect by binding to the bacterial enzymes DNA gyrase (topoisomerase II) and topoisomerase IV. Inhibition of these enzymes prevents the supercoiling and separation of bacterial DNA required for replication and transcription, leading to bactericidal activity against susceptible Gram‑negative and some Gram‑positive organisms. The drug penetrates tissues, including the prostate and respiratory mucosa, achieving concentrations above the minimum inhibitory concentration for target pathogens.

Side Effects

Norfloxacin may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Diarrhea: loose stools, usually self‑limiting.
  • Headache: transient cranial discomfort.

Serious or Rare Side Effects

  • Tendon rupture: risk of Achilles or other tendon tears.
  • QT interval prolongation: potential cardiac arrhythmia.
  • Severe allergic reactions: anaphylaxis or angioedema.

Precautions & Warnings

When prescribing norfloxacin, clinicians should consider several precautionary measures to minimize risks.

  • Renal impairment: adjust dose or monitor renal function in patients with reduced clearance.
  • Hepatic disease: use with caution in severe liver dysfunction.
  • Concomitant QT‑prolonging drugs: avoid or monitor cardiac rhythm.
  • History of tendon disorders: avoid use in patients with prior tendon injury.
  • Pregnancy and lactation: safety not established; use only if benefits outweigh risks.
  • Store at ambient temperature: keep below 25 °C, in original packaging, protected from moisture and light.

Avoid Interactions

Norfloxacin interacts with several medicines; awareness of the interaction level guides clinical decisions.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: markedly reduce absorption; separate dosing by at least 2 hours.
  • Warfarin: may enhance anticoagulant effect, increasing INR; close monitoring required.
  • Theophylline: increased plasma levels leading to toxicity.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may increase risk of CNS stimulation.
  • Corticosteroids: combined use may raise tendon rupture risk.
  • Diabetic agents (e.g., insulin, sulfonylureas): potential for hypoglycemia; monitor blood glucose.

Frequently Asked Questions

Nolicin, containing norfloxacin, is prescribed for infections such as uncomplicated urinary tract infections, acute bacterial prostatitis, bacterial gastroenteritis, and certain respiratory tract infections caused by susceptible bacteria.

Norfloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication and transcription. By inhibiting these targets, it prevents bacterial cell division and leads to bacterial death.

The exact dose of Nolicin is set by the prescribing clinician based on the type and severity of infection, patient age, renal and hepatic function, and any concomitant medications.

Safety data for norfloxacin in pregnancy and lactation are limited. It is generally avoided unless the potential benefit justifies the potential risk to the fetus or infant, and only under medical supervision.

To order Nolicin, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Noricin shares the class‑wide mechanism of DNA‑gyrase inhibition but differs in its spectrum of activity, pharmacokinetic profile, and tissue penetration. Compared with agents like ciprofloxacin, norfloxacin may have higher urinary concentrations, making it particularly useful for urinary and prostate infections.

Store Nolicin tablets at ambient temperature, preferably below 25 °C. Keep them in the original container, protect from moisture and direct light, and ensure the blister pack is closed after each use.

Nolicin is taken orally, usually with a full glass of water. The tablet should be swallowed whole and not crushed or chewed, unless a prescriber provides specific instructions.

Serious adverse events include tendon rupture, especially in the Achilles tendon, QT‑interval prolongation that can lead to arrhythmias, and severe allergic reactions such as anaphylaxis. Patients should be advised to report any sudden joint pain, palpitations, or signs of hypersensitivity immediately.

Nolicin should be avoided in patients with a known hypersensitivity to norfloxacin or other fluoroquinolones, those with a history of tendon disorders related to fluoroquinolone use, and individuals taking medications that significantly prolong the QT interval without close monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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