Product image of Noliterax (Indapamide, Perindopril Arginine) supplied by GNH India

Noliterax

Active Ingredient:
Indapamide, Perindopril Arginine
Origin:
EU

Noliterax (Indapamide, Perindopril Arginine)

Indapamide and Perindopril arginine, the active ingredients in Noliterax, are a diuretic and an ACE inhibitor presented as an oral tablet for oral use. They treat hypertension by lowering blood pressure in adult patients.
GNH India supplies Noliterax as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Les Laboratoires Servier (Suresnes)

1
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Indications & Clinical Uses

  • Noliterax, a combination antihypertensive, is used to manage elevated blood pressure.
  • Hypertension: reduces systolic and diastolic blood pressure in patients with primary hypertension.
  • Essential hypertension: provides additive blood‑pressure‑lowering effect through diuresis and vasodilation.
  • High‑risk cardiovascular patients: helps achieve target blood pressure when monotherapy is insufficient.

How It Works

  • Indapamide acts as a thiazide‑like diuretic by inhibiting sodium reabsorption in the distal tubule, promoting natriuresis and diuresis. Perindopril arginine is an ACE inhibitor that blocks conversion of angiotensin I to angiotensin II, resulting in vasodilation, reduced aldosterone secretion, and decreased peripheral resistance. The combined actions produce additive reduction of arterial pressure.

Side Effects

Common Side Effects

  • Dizziness or light‑headedness, especially after the first dose.
  • Headache or mild fatigue.
  • Increased urinary frequency or mild electrolyte imbalance.

Serious or Rare Side Effects

  • Severe hypotension or syncope.
  • Angioedema, including facial or airway swelling.
  • Hyperkalemia or significant renal function decline.
  • Pancreatitis or severe allergic reactions.
  • Blood dyscrasias such as agranulocytosis.

Precautions & Warnings

Before initiating therapy, consider the following precautions.

  • Monitor blood pressure: adjust therapy if target levels are not achieved.
  • Assess renal function: avoid or adjust dose in severe renal impairment.
  • Check electrolytes: watch for potassium and sodium disturbances.
  • Use caution in diabetes: monitor glucose as diuretic may affect control.
  • Pregnancy and lactation: safety not established; avoid unless clearly needed.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

When prescribing Noliterax, be aware of potential drug interactions.

Major Interactions (Avoid)

  • Concomitant use with aliskiren in diabetic patients may increase risk of renal impairment.
  • Co‑administration with potassium‑sparing diuretics or supplements can cause dangerous hyperkalemia.
  • NSAIDs combined with ACE inhibitors may reduce antihypertensive effect and impair renal function.

Moderate Interactions (Monitor Closely)

  • Lithium levels may rise when taken with thiazide‑like diuretics; monitor serum lithium.
  • Other antihypertensives can produce additive blood‑pressure lowering; adjust doses accordingly.
  • Corticosteroids may increase potassium loss; monitor electrolytes.
  • Digoxin efficacy can be altered by electrolyte shifts; observe cardiac status.

Frequently Asked Questions

Noliterax is prescribed to lower high blood pressure in adults. It combines a thiazide‑like diuretic with an ACE inhibitor, providing a dual mechanism that helps achieve target blood‑pressure levels in patients with primary hypertension or those who need additional control beyond a single agent.

Indapamide reduces fluid volume by blocking sodium reabsorption in the kidney’s distal tubule, leading to increased urine output. Perindopril arginine inhibits the angiotensin‑converting enzyme, preventing formation of angiotensin II, which relaxes blood vessels and decreases aldosterone release. Together they lower vascular resistance and circulating volume, producing an additive antihypertensive effect.

The specific dose of Noliterax is determined by the prescribing healthcare professional based on the individual’s blood‑pressure readings, renal function, and overall health status. Patients should follow the prescriber’s instructions and not adjust the dose without medical advice.

Safety of Noliterax in pregnancy and lactation has not been established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To request Noliterax, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with single‑agent therapies, Noliterax offers combined diuretic and ACE‑inhibitor actions in one tablet, which can simplify regimens and improve adherence. It may provide greater blood‑pressure reduction than either component alone, but individual response varies, and clinicians choose therapy based on patient profile and comorbidities.

Noliterax tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect from moisture and light. Keep the container tightly closed and out of reach of children.

Noliterax is taken orally, usually once daily, with or without food, as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush or chew unless specifically instructed.

Serious risks include severe hypotension, angioedema (swelling of the face, lips, tongue, or airway), hyperkalemia, and significant renal impairment. Patients should seek immediate medical attention if they experience symptoms such as sudden swelling, difficulty breathing, fainting, or marked decrease in urine output.

Noliterax is contraindicated in patients with known hypersensitivity to indapamide, perindopril, or any component of the formulation, as well as in individuals with severe renal impairment, hyperkalemia, or a history of angioedema related to ACE‑inhibitor therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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