Product image of Nolpaza (Pantoprazole) supplied by GNH India

Nolpaza

Active Ingredient:
Pantoprazole
Origin:
EU

Nolpaza (Pantoprazole)

Pantoprazole, the active ingredient in Nolpaza, is a proton pump inhibitor presented as a 40 mg injectable solution for intravenous use. It treats acid‑related disorders such as erosive esophagitis, gastro‑oesophageal reflux disease, Zollinger‑Ellison syndrome and helps prevent NSAID‑induced gastric ulcers in adults.

GNH India supplies Nolpaza as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

Pantoprazole is a proton pump inhibitor used to reduce gastric acid secretion in several acid‑related conditions.

  • Erosive esophagitis: promotes healing of damaged esophageal lining by decreasing acid exposure.
  • Gastro‑oesophageal reflux disease (GERD): relieves heartburn and prevents reflux‑related mucosal injury.
  • Zollinger‑Ellison syndrome: controls excessive gastric acid production associated with gastrin‑secreting tumors.
  • Prevention of NSAID‑induced gastric ulcers: reduces risk of ulcer formation in patients receiving non‑steroidal anti‑inflammatory drugs.

How It Works

  • Pantoprazole selectively and irreversibly binds to the H+/K+ ATPase enzyme (the gastric proton pump) on the secretory surface of parietal cells. By inhibiting this final step of acid production, it markedly lowers both basal and stimulated gastric acid secretion, leading to an increase in gastric pH.

Side Effects

Pantoprazole may be associated with several adverse reactions, ranging from mild to serious.

Common Side Effects

  • Headache: mild, transient headache reported in clinical use.
  • Diarrhea: loose stools occurring during treatment.
  • Nausea: occasional feeling of queasiness.
  • Injection site reactions: pain, erythema, or swelling at the intravenous site.

Serious or Rare Side Effects

  • Severe hypersensitivity: rash, angioedema, or anaphylaxis requiring immediate medical attention.
  • Clostridioides difficile infection: rare cases of severe colitis.
  • Long‑term use concerns: rare reports of osteoporosis‑related fractures or hypomagnesemia.

Precautions & Warnings

When prescribing Pantoprazole injectable solution, clinicians should consider several precautionary measures to ensure safe use.

  • Renal impairment: adjust use in patients with severe kidney dysfunction.
  • Hepatic impairment: monitor liver function in patients with moderate to severe hepatic disease.
  • Pregnancy and lactation: category B, use only if benefit outweighs potential risk.
  • Concomitant use with CYP2C19 substrates: may increase plasma levels of drugs metabolized by this pathway.
  • Monitoring electrolytes: prolonged therapy can lead to hypomagnesemia; check serum magnesium periodically.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Pantoprazole can affect the pharmacokinetics of other medicines; awareness of key interactions helps avoid adverse outcomes.

Major Interactions (Avoid)

  • Ketoconazole or itraconazole oral formulations: reduced absorption; avoid concurrent use.
  • Atazanavir: decreased plasma concentration leading to loss of antiviral effect.
  • Clopidogrel: reduced activation, potentially diminishing antiplatelet activity.

Moderate Interactions (Monitor Closely)

  • Warfarin: may increase INR; monitor coagulation parameters.
  • Digoxin: possible increase in serum levels; check digoxin concentrations.
  • Methotrexate (high dose): may increase toxicity; monitor renal function and drug levels.

Frequently Asked Questions

Nolpaza contains pantoprazole and is indicated for the treatment of acid‑related disorders such as erosive esophagitis, gastro‑oesophageal reflux disease, Zollinger‑Ellison syndrome, and for the prevention of gastric ulcers in patients receiving NSAIDs.

Pantoprazole inhibits the gastric H+/K+ ATPase pump, the final step in acid secretion by parietal cells. This irreversible blockade reduces both basal and stimulated gastric acid output, raising gastric pH and allowing mucosal healing.

The specific dose and infusion rate are determined by the prescribing clinician based on the patient’s condition, severity, and response. Typical intravenous regimens range from a single 40 mg dose to daily administrations, but exact dosing must follow the prescriber’s order.

Pantoprazole is classified as Pregnancy Category B, indicating no evidence of risk in animal studies and a lack of well‑controlled human data. It should be used in pregnancy or lactation only when the potential benefit justifies any potential risk to the fetus or infant.

To request Nolpaza, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and required import documentation.

Nolpaza (pantoprazole) offers a stable intravenous formulation with a low potential for drug‑drug interactions compared with some oral PPIs. It is often preferred in hospital settings where rapid, controlled acid suppression is needed, whereas agents like omeprazole may have more variable IV stability.

Nolpaza should be stored at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the product in its original packaging until use to maintain sterility and potency.

Nolpaza is given by intravenous infusion. The 40 mg vial is typically diluted in a compatible IV fluid and infused over 15‑30 minutes, according to the prescribing clinician’s instructions and institutional protocols.

Serious adverse events include severe hypersensitivity reactions such as anaphylaxis, rare Clostridioides difficile‑associated colitis, and long‑term complications like hypomagnesemia, osteoporosis‑related fractures, and potential renal impairment with prolonged use.

Nolpaza is contraindicated in patients with known hypersensitivity to pantoprazole or any component of the formulation. Caution is advised in individuals with severe hepatic impairment, and it should be used only when clearly indicated in patients with significant renal dysfunction.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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