Product image of Nolus (Montelukast) supplied by GNH India

Nolus

Active Ingredient:
Montelukast
Origin:
EU

Nolus (Montelukast)

Montelukast, the active ingredient in Nolus, is a leukotriene receptor antagonist presented as an oral tablet for oral use. It is indicated for the management of asthma, exercise‑induced bronchoconstriction, and allergic rhinitis in adults and children as prescribed by a healthcare professional. The medication works by blocking specific inflammatory mediators that cause narrowing of the airways.

GNH India supplies Nolus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Lanova Farmaceutici S.R.L.

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Indications & Clinical Uses

Montelukast is used to manage conditions mediated by leukotrienes, primarily within the respiratory and allergic disease spectrum.

  • Asthma: reduces bronchoconstriction and airway inflammation, helping to prevent asthma attacks.
  • Exercise‑induced bronchoconstriction: prevents narrowing of the airways triggered by physical activity.
  • Allergic rhinitis: alleviates nasal congestion, sneezing and itching caused by allergic inflammation.

How It Works

  • Montelukast selectively antagonizes the cysteinyl leukotriene receptor CysLT1, inhibiting the actions of leukotrienes D4, C4, and E4. By blocking these mediators, it reduces bronchoconstriction, vascular permeability, and inflammatory cell recruitment in the airways, thereby improving respiratory function and decreasing allergic symptoms.

Side Effects

Montelukast may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Abdominal pain: occasional discomfort or cramps.
  • Cough: transient irritation of the throat.
  • Upper respiratory infection: mild cold‑like symptoms.
  • Diarrhea: loose stools that resolve spontaneously.
  • Fatigue: feeling of tiredness without exertion.

Serious or Rare Side Effects

  • Allergic reactions: rash, swelling, or hives requiring medical attention.
  • Neuropsychiatric events: mood changes, depression, or suicidal thoughts.
  • Hepatotoxicity: abnormal liver enzymes indicating liver stress.
  • Stevens‑Johnson syndrome: severe skin blistering and mucosal involvement.
  • Anaphylaxis: rapid onset of breathing difficulty and hypotension.
  • Blood dyscrasias: rare cases of neutropenia or thrombocytopenia.

Precautions & Warnings

Before prescribing Montelukast, clinicians should consider several safety aspects.

  • Monitor neuropsychiatric symptoms: watch for mood changes, depression, or suicidal ideation.
  • Assess liver function: consider baseline tests in patients with hepatic impairment.
  • Review concomitant medications: avoid drugs that strongly induce CYP3A4 enzymes.
  • Use caution in children: pediatric dosing should follow prescriber guidance.
  • Pregnancy and lactation: discuss potential risks with the patient as data are limited.
  • Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Montelukast can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Rifampin: strong enzyme inducer that may lower montelukast plasma levels.
  • Phenobarbital: reduces drug exposure through hepatic enzyme induction.

Moderate Interactions (Monitor Closely)

  • Warfarin: may increase anticoagulant effect; monitor INR.
  • Carbamazepine: can modestly decrease montelukast concentrations.
  • Fluconazole: potential slight increase in exposure; observe for side effects.
  • St. John's Wort: herbal inducer that may reduce effectiveness.

Frequently Asked Questions

Nolus contains montelukast, which is prescribed for asthma, exercise‑induced bronchoconstriction, and allergic rhinitis. It helps control airway narrowing and reduces inflammation associated with these respiratory and allergic disorders.

Montelukast blocks the cysteinyl leukotriene receptor CysLT1, preventing leukotrienes D4, C4, and E4 from binding. This inhibition reduces bronchoconstriction, mucus production, and inflammatory cell recruitment, leading to improved breathing and fewer allergy symptoms.

The appropriate dose of Nolus is determined by the prescribing healthcare professional based on the patient’s age, weight, and specific condition. Dosage instructions are provided on the prescription label and should be followed exactly as directed.

Safety data for montelukast in pregnancy and lactation are limited. Healthcare providers should weigh the potential benefits against possible risks and discuss any concerns with the patient before initiating therapy.

To request Nolus, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nolus (montelukast) belongs to the leukotriene receptor antagonist class, offering an oral alternative to inhaled corticosteroids or long‑acting bronchodilators. It is particularly useful for patients who need additional control of leukotriene‑mediated inflammation or who prefer a once‑daily tablet.

Nolus should be stored below 25 °C in its original packaging, protected from moisture and direct sunlight. Keep the product out of reach of children and avoid storing it in bathrooms or other humid environments.

Nolus is taken orally, usually once daily in the evening, with or without food. The tablet should be swallowed whole with a glass of water and not chewed or crushed unless otherwise instructed by a healthcare professional.

Serious adverse events, though rare, include severe allergic reactions, neuropsychiatric effects such as depression or suicidal thoughts, and liver enzyme abnormalities. Patients should seek immediate medical attention if they experience rash, swelling, mood changes, or signs of liver dysfunction.

Nolus is contraindicated in patients with known hypersensitivity to montelukast or any component of the formulation. Caution is advised for individuals with severe hepatic impairment, active psychiatric disorders, or those taking strong CYP3A4 inducers without proper monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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