Product image of Nolvadex D (Tamoxifen Citrate) supplied by GNH India

Nolvadex D

Active Ingredient:
Tamoxifen Citrate
Origin:
EU

Nolvadex D (Tamoxifen Citrate)

Tamoxifen citrate, the active ingredient in Nolvadex D, is a selective estrogen receptor modulator presented as an oral formulation for oral use. It is employed in the treatment of estrogen receptor‑positive breast cancer and in the prevention of breast cancer in high‑risk women.
GNH India supplies Nolvadex D as a licensed, GDP‑compliant international pharmaceutical supplier serving oncology centres, hospitals and pharmacies worldwide.

Manufacturer / TM Owner

Astrazeneca Ab

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Indications & Clinical Uses

Tamoxifen citrate acts on estrogen‑dependent pathways in breast tissue and is indicated for several oncologic indications.

  • Estrogen receptor‑positive breast cancer (adjuvant and metastatic): improves disease‑free survival and reduces tumor progression.
  • High‑risk women for breast cancer prevention: lowers the incidence of invasive breast cancer.
  • Ductal carcinoma in situ after surgery: decreases the risk of local recurrence.

How It Works

  • Tamoxifen citrate binds competitively to estrogen receptors in breast tissue, blocking estrogen‑driven proliferation (anti‑estrogenic effect). In bone and uterine tissue it acts as a partial agonist, providing estrogenic activity that helps maintain bone density while exerting a neutral or modest stimulatory effect on the uterus.

Side Effects

Tamoxifen citrate may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Hot flashes: transient sensation of warmth and sweating.
  • Nausea: mild to moderate upset stomach.
  • Menstrual irregularities: changes in cycle length or flow.
  • Fatigue: general feeling of tiredness.

Serious or Rare Side Effects

  • Thromboembolic events: deep‑vein thrombosis or pulmonary embolism.
  • Endometrial carcinoma: abnormal uterine bleeding indicating possible cancer.
  • Severe liver injury: jaundice, elevated liver enzymes, or hepatic failure.

Precautions & Warnings

When using Tamoxifen citrate, clinicians should observe several safety measures.

  • Monitor hepatic function: obtain baseline liver tests and repeat periodically.
  • Assess thromboembolic risk: avoid in patients with a history of clotting disorders.
  • Evaluate uterine health: consider gynecologic assessment for postmenopausal women.
  • Pregnancy considerations: avoid use during pregnancy and discuss effective contraception.
  • Drug interactions: review concomitant medications for CYP2D6 inhibitors.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Tamoxifen citrate interacts with several medicines that can alter its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP2D6 inhibitors (e.g., paroxetine, fluoxetine): may increase tamoxifen plasma levels and toxicity.
  • Warfarin: tamoxifen can enhance anticoagulant effect; monitor INR closely.
  • Aromatase inhibitors: opposing mechanisms may reduce therapeutic benefit.

Moderate Interactions (Monitor Closely)

  • Antidepressants metabolized by CYP2D6: possible altered drug concentrations.
  • SSRIs that are weak CYP2D6 inhibitors (e.g., sertraline): monitor clinical response.
  • Certain antacids: may affect absorption; separate administration times.

Frequently Asked Questions

Nolvadex D contains tamoxifen citrate, which is prescribed to treat estrogen receptor‑positive breast cancer in both early‑stage (adjuvant) and metastatic settings, and to reduce the risk of developing breast cancer in women who are considered high‑risk.

Tamoxifen citrate acts as a competitive antagonist at estrogen receptors in breast tissue, blocking estrogen‑driven cell growth. In bone and the uterus it behaves as a partial agonist, providing modest estrogenic activity while still inhibiting tumor proliferation.

The dosage of tamoxifen citrate is individualized by the prescribing clinician based on the specific indication, disease stage, and patient characteristics. Only a qualified healthcare professional should determine the appropriate regimen.

Tamoxifen citrate is contraindicated in pregnancy because it can cause fetal harm. Women of child‑bearing potential should use effective contraception while on therapy. Safety during breastfeeding has not been established, and nursing is generally discouraged.

To request Nolvadex D, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Nolvadex D (tamoxifen) is a selective estrogen receptor modulator, whereas aromatase inhibitors lower systemic estrogen levels. Tamoxifen is often chosen for pre‑menopausal patients and for long‑term risk reduction, while aromatase inhibitors are preferred in post‑menopausal settings. The choice depends on hormonal status, side‑effect profile, and clinical goals.

Store Nolvadex D at ambient temperature below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Nolvadex D is taken orally, usually as a whole tablet swallowed with water. It should be taken at the same time each day, with or without food, as directed by the prescribing clinician.

The most serious risks include thromboembolic events such as deep‑vein thrombosis or pulmonary embolism, development of endometrial cancer, and severe liver injury. Patients should be monitored for signs of clotting, abnormal uterine bleeding, or hepatic dysfunction.

Nolvadex D should be avoided in patients with a known hypersensitivity to tamoxifen or any of its excipients, in those with active or recent thromboembolic disease, and in pregnant women. Clinicians should also exercise caution in patients with severe liver impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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