Product image of Nolvadex D (Tamoxifen Citrate) supplied by GNH India

Nolvadex D

Active Ingredient:
Tamoxifen Citrate
Origin:
EU

Nolvadex D (Tamoxifen Citrate)

Tamoxifen citrate, the active ingredient in Nolvadex D, is a selective estrogen receptor modulator presented as an oral tablet for oral use. It treats estrogen receptor‑positive breast cancer, helps prevent disease in high‑risk women, and is used for gynecomastia associated with certain conditions or therapies.

GNH India supplies Nolvadex D as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Astrazeneca Uk Limited

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Indications & Clinical Uses

Nolvadex D is a selective estrogen receptor modulator used in several estrogen‑driven conditions.

  • Estrogen receptor‑positive breast cancer: reduces recurrence risk and controls disease progression.
  • High‑risk women for breast cancer prevention: lowers incidence of invasive breast cancer.
  • Gynecomastia associated with certain conditions or treatments: diminishes breast tissue growth and related discomfort.

How It Works

  • Tamoxifen citrate binds competitively to estrogen receptors in breast tissue, acting as an antagonist that blocks estrogen‑driven cellular proliferation. In bone and uterine tissue it exhibits partial agonist activity, preserving bone density while still inhibiting tumor growth. The drug is metabolized primarily by CYP3A4 and CYP2D6 to active metabolites that sustain receptor blockade.

Side Effects

Common Side Effects

  • Hot flashes: transient feeling of warmth and sweating.
  • Nausea: mild to moderate upset stomach.
  • Fatigue: general tiredness or lack of energy.
  • Menstrual irregularities: changes in cycle length or flow.

Serious or Rare Side Effects

  • Deep vein thrombosis or pulmonary embolism: blood clots in veins or lungs.
  • Endometrial cancer: abnormal growth of uterine lining.
  • Severe liver function abnormalities: elevated enzymes or hepatitis.
  • Life‑threatening allergic reactions: rash, swelling, or anaphylaxis.

Precautions & Warnings

Before initiating therapy, clinicians should assess individual risk factors and monitor relevant parameters.

  • Liver function monitoring: perform baseline and periodic liver enzyme tests.
  • Thromboembolic risk assessment: evaluate history of clotting disorders.
  • Uterine health evaluation: consider baseline gynecologic exam for endometrial risk.
  • Contraceptive counseling: advise on effective non‑estrogen contraception during treatment.
  • Store at ambient temperature: keep in original packaging, protect from moisture and heat.

Avoid Interactions

Tamoxifen citrate may interact with several medicines; careful review is essential.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): reduce tamoxifen effectiveness.
  • CYP2D6‑inhibiting SSRIs (e.g., paroxetine, fluoxetine): lower active metabolite levels.
  • Warfarin: may increase anticoagulant effect and bleeding risk.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole): may raise tamoxifen concentrations.
  • Other anticoagulants (e.g., heparin): require coagulation monitoring.
  • Herbal supplements such as St. John’s wort: potential induction of metabolism.

Frequently Asked Questions

Nolvadex D, containing tamoxifen citrate, is prescribed for estrogen receptor‑positive breast cancer (both adjuvant and metastatic settings), for reducing breast cancer risk in women at high risk, and for treating gynecomastia that arises from certain medical conditions or therapies.

Tamoxifen citrate acts as a competitive antagonist at estrogen receptors in breast tissue, blocking estrogen‑driven tumor cell growth. It also shows partial agonist activity in bone and uterine tissue, helping maintain bone density while still inhibiting cancer proliferation.

The specific dose of Nolvadex D is determined by the prescribing clinician based on the patient’s diagnosis, disease stage, and individual health factors. Dosage regimens are tailored to each patient and should follow the prescriber’s instructions.

Tamoxifen citrate is contraindicated in pregnancy because it can cause fetal harm. It is also not recommended while breastfeeding, as it may pass into breast milk and affect the infant. Women of child‑bearing potential should use effective contraception during treatment.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Nolvadex D belongs to the selective estrogen receptor modulator class, differing from aromatase inhibitors and chemotherapy agents. While aromatase inhibitors lower overall estrogen levels, tamoxifen blocks estrogen receptors directly, offering an oral option with a distinct side‑effect profile and suitability for pre‑menopausal patients.

Nolvadex D should be stored at ambient temperature, below 25 °C, in its original container. Keep the product away from moisture, direct sunlight, and excessive heat to maintain potency throughout its shelf life.

Nolvadex D is taken orally, usually as a tablet swallowed with water. The exact frequency and duration are prescribed by the treating physician and may vary according to the indication and patient response.

Serious risks include thromboembolic events such as deep‑vein thrombosis or pulmonary embolism, endometrial cancer, severe liver toxicity, and life‑threatening allergic reactions. Patients should be monitored regularly for signs of these conditions and report any concerning symptoms promptly.

Nolvadex D is contraindicated in patients with a known hypersensitivity to tamoxifen or any of its excipients, in pregnant women, and in individuals with active thromboembolic disease or uncontrolled liver disease. Clinicians should evaluate each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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