Product image of Nomanesit (Naproxen Sodium, Sumatriptan Succinate) supplied by GNH India

Nomanesit

Active Ingredient:
Naproxen Sodium, Sumatriptan Succinate
Origin:
EU

Nomanesit (Naproxen Sodium, Sumatriptan Succinate)

Naproxen sodium and sumatriptan succinate, the active ingredients in Nomanesit, are an NSAID and a 5‑HT1B/1D receptor agonist presented as oral tablets for oral use. The combination is indicated for the acute treatment of migraine attacks in adults, providing both anti‑inflammatory and vasoconstrictive actions for rapid symptom relief.

GNH India supplies Nomanesit as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to EU GMP standards and offering secure, temperature‑controlled logistics for global distribution.

Manufacturer / TM Owner

Orion Corporation

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Indications & Clinical Uses

Nomanesit combines an NSAID and a triptan to address migraine pathophysiology.

  • Migraine with aura: aborts attacks and reduces associated symptoms such as nausea and photophobia.
  • Migraine without aura: provides rapid headache relief and improves functional ability.
  • Acute migraine attacks: delivers dual action to lessen pain intensity and duration.

How It Works

  • Naproxen sodium inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, decreasing prostaglandin synthesis and inflammation. Sumatriptan succinate selectively activates 5‑HT1B and 5‑HT1D receptors, causing cranial vasoconstriction and blocking release of vasoactive neuropeptides, thereby terminating migraine attacks.

Side Effects

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Dizziness: transient light‑headedness.
  • Dry mouth: reduced salivation.
  • Abdominal pain: discomfort in the stomach area.

Serious or Rare Side Effects

  • Chest pain or tightness: possible cardiac ischemia.
  • Severe allergic reaction (anaphylaxis): swelling, difficulty breathing.
  • Serotonin syndrome: agitation, hyperthermia, tremor.
  • Cardiovascular events: stroke or myocardial infarction.
  • Severe liver injury: jaundice, elevated enzymes.
  • Stevens‑Johnson syndrome: severe skin rash.

Precautions & Warnings

Before prescribing Nomanesit, clinicians should evaluate patient‑specific risk factors.

  • Assess cardiovascular risk: patients with coronary artery disease should be evaluated before use.
  • Avoid in uncontrolled hypertension: monitor blood pressure closely.
  • Use caution with other serotonergic agents: risk of serotonin syndrome.
  • Avoid in patients with known hypersensitivity to NSAIDs or triptans.
  • Pregnancy and lactation: safety not established; use only if benefit outweighs risk.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture and light.

Avoid Interactions

Nomanesit may interact with several drug classes; monitoring is essential.

Major Interactions (Avoid)

  • Concomitant use with MAO inhibitors: risk of serotonin syndrome.
  • Combined with other triptans or ergot derivatives: increased vasoconstriction risk.
  • Use with potent CYP3A4 inhibitors: may raise sumatriptan plasma levels.
  • Concurrent anticoagulants/antiplatelet agents: heightened bleeding risk.

Moderate Interactions (Monitor Closely)

  • Co‑administration with SSRIs or SNRIs: monitor for serotonin syndrome.
  • Use with other NSAIDs: increased gastrointestinal toxicity.
  • Combination with antihypertensives: may reduce antihypertensive effect.

Frequently Asked Questions

Nomanesit is a prescription oral tablet that combines naproxen sodium and sumatriptan succinate for the acute treatment of migraine attacks in adults, helping to relieve headache and associated symptoms such as nausea and light sensitivity.

Naproxen sodium inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which reduces the production of prostaglandins that cause inflammation and pain, contributing to the overall relief of migraine-related discomfort.

The specific dose and dosing schedule of Nomanesit are determined by the prescribing healthcare professional based on the individual patient's medical condition, response to therapy, and any concomitant medications.

Safety of Nomanesit in pregnancy or while breastfeeding has not been established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified clinician.

To request Nomanesit, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Nomanesit offers a dual mechanism by pairing an NSAID with a triptan, which can provide faster and more comprehensive relief compared with single‑agent therapies such as a stand‑alone triptan or NSAID alone, especially for patients who benefit from both anti‑inflammatory and vasoconstrictive actions.

Store Nomanesit tablets at ambient temperature below 25 °C, in the original packaging, and protect them from moisture and direct light to maintain product stability throughout its shelf life.

Nomanesit is taken orally with a full glass of water. It is usually administered at the onset of a migraine attack, as directed by a healthcare professional, and should not be taken more frequently than prescribed.

Serious risks include cardiovascular events such as chest pain or myocardial infarction, severe allergic reactions (anaphylaxis), serotonin syndrome when combined with other serotonergic drugs, and rare but severe skin reactions like Stevens‑Johnson syndrome.

Patients with known hypersensitivity to naproxen, other NSAIDs, or sumatriptan; those with uncontrolled hypertension, recent cardiovascular events, or severe liver disease should avoid Nomanesit. A clinician should evaluate each individual's medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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