Product image of Nomexor (Nebivolol) supplied by GNH India

Nomexor

Active Ingredient:
Nebivolol
Origin:
EU

Nomexor (Nebivolol)

Nebivolol, the active ingredient in Nomexor, is a selective β1‑adrenergic blocker presented as an oral tablet for systemic use. It is indicated for the management of essential hypertension and for reducing morbidity in patients with heart failure with reduced ejection fraction.

GNH India supplies Nomexor as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality‑controlled manufacturing and regulatory compliance across EU and global markets. Our distribution network adheres to stringent quality standards and provides reliable logistics for timely delivery.

Manufacturer / TM Owner

Menarini International Operations Luxembourg S.A.

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Indications & Clinical Uses

Nebivolol is used to treat cardiovascular conditions that involve elevated blood pressure or impaired cardiac function.

  • Essential hypertension: lowers systolic and diastolic blood pressure to reduce cardiovascular risk.
  • Heart failure with reduced ejection fraction: improves ventricular performance and decreases mortality.
  • Left ventricular dysfunction: supports cardiac output and mitigates progression of heart failure.

How It Works

  • Nebivolol selectively blocks β1‑adrenergic receptors in cardiac tissue, decreasing heart rate and myocardial contractility. Concurrently, it stimulates endothelial nitric‑oxide synthase, producing nitric oxide–mediated vasodilation that reduces peripheral vascular resistance. The combined effect lowers systemic blood pressure while preserving cardiac output, making it effective for hypertension and heart‑failure management.

Side Effects

Nebivolol may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Dizziness or light‑headedness, especially on standing.
  • Fatigue or general weakness.
  • Bradycardia: slower than normal heart rate.
  • Nausea or mild gastrointestinal upset.
  • Peripheral edema: swelling of ankles or feet.

Serious or Rare Side Effects

  • Severe bradycardia or sinus arrest.
  • Marked hypotension leading to fainting.
  • Atrioventricular block or other cardiac conduction disturbances.
  • Bronchospasm in patients with reactive airway disease.
  • Allergic reactions such as rash, pruritus, or angioedema.
  • Hepatic dysfunction manifested by elevated liver enzymes.

Precautions & Warnings

Before initiating Nebivolol therapy, clinicians should consider several safety measures.

  • Blood pressure monitoring: ensure adequate control without excessive hypotension.
  • Heart rate assessment: avoid use in patients with baseline severe bradycardia.
  • Asthma or chronic obstructive pulmonary disease: use with caution due to potential bronchoconstriction.
  • Renal or hepatic impairment: dose adjustment may be required.
  • Discontinuation: taper gradually to prevent rebound hypertension.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Nebivolol can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Other beta‑blockers: additive bradycardia and hypotension.
  • Verapamil or diltiazem: increased risk of atrioventricular block.
  • Potent CYP2D6 inhibitors (e.g., paroxetine, fluoxetine): elevated nebivolol plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Diuretics: may enhance antihypertensive effect, requiring blood pressure checks.
  • Insulin or oral hypoglycemics: nebivolol can mask hypoglycemia symptoms, necessitating glucose monitoring.

Frequently Asked Questions

Nomexor contains nebivolol, which is prescribed to lower high blood pressure (essential hypertension) and to improve outcomes in patients with heart failure that has a reduced ejection fraction. These indications are supported by clinical guidelines for cardiovascular risk reduction.

Nebivolol selectively blocks β1‑adrenergic receptors in the heart, decreasing heart rate and contractility. At the same time, it stimulates nitric‑oxide release from the endothelium, causing blood vessels to relax. The combined actions reduce cardiac output and peripheral resistance, leading to lower blood pressure.

The appropriate dose of Nomexor is determined by the prescribing clinician based on the patient’s medical condition, response to therapy, and any co‑existing health issues. Dosage adjustments may be needed for renal or hepatic impairment, and the prescriber will provide specific instructions.

Safety data for nebivolol in pregnancy and lactation are limited, and the drug is generally not recommended unless the potential benefit justifies the risk. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss alternatives with their healthcare provider.

To place an order, submit an enquiry on the Nomexor product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and import documentation.

Nebivolol is a third‑generation, β1‑selective blocker that also promotes nitric‑oxide‑mediated vasodilation, which can improve endothelial function. Compared with older non‑selective beta‑blockers, it may cause fewer metabolic side effects and offers additional vasodilatory benefits, making it a preferred option for some patients with hypertension and heart failure.

Nomexor tablets should be stored at room temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the container tightly closed and out of reach of children.

Nomexor is taken orally, usually once daily with or without food, as directed by the prescribing clinician. The tablet should be swallowed whole with a glass of water and not chewed or crushed unless specifically instructed.

Serious risks include severe bradycardia, marked hypotension, atrioventricular block, bronchospasm in patients with reactive airway disease, and rare allergic reactions such as angioedema. Patients should seek immediate medical attention if they experience fainting, rapid heartbeat, difficulty breathing, or swelling of the face or throat.

Nomexor is contraindicated in patients with known hypersensitivity to nebivolol or any excipients, those with severe bradycardia, second‑ or third‑degree heart block without a pacemaker, and individuals with uncompensated heart failure. Caution is also advised for patients with asthma, severe liver disease, or uncontrolled diabetes.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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