Product image of Nomexor Plus Hct (Hydrochlorothiazide, Nebivolol) supplied by GNH India

Nomexor Plus Hct

Active Ingredient:
Hydrochlorothiazide, Nebivolol
Origin:
EU

Nomexor Plus Hct (Hydrochlorothiazide, Nebivolol)

Hydrochlorothiazide and Nebivolol, the active ingredients in Nomexor Plus Hct, are a thiazide diuretic and a selective β1‑adrenergic blocker presented as tablets for oral use. They are employed to lower elevated blood pressure in adult patients with hypertension.

GNH India supplies Nomexor Plus Hct as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for global distribution.

Manufacturer / TM Owner

Menarini International Operations Luxembourg S.A.

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Indications & Clinical Uses

  • Nomexor Plus Hct combines a thiazide diuretic and a beta‑blocker to treat hypertension and related blood‑pressure disorders.
  • Essential hypertension: reduces systolic and diastolic pressure in adults.
  • Stage 1 hypertension: helps achieve target blood‑pressure levels.
  • Stage 2 hypertension: provides additional control when monotherapy is insufficient.

How It Works

  • Hydrochlorothiazide inhibits sodium‑chloride reabsorption in the distal convoluted tubule, increasing urinary excretion of water and electrolytes, which lowers plasma volume. Nebivolol selectively blocks β1‑adrenergic receptors, decreasing heart rate and contractility, while also stimulating nitric‑oxide release for vasodilation. The combined actions result in reduced peripheral resistance and blood pressure.

Side Effects

Common adverse reactions are generally mild and related to the pharmacologic actions of the two components.

Common Side Effects

  • Dizziness
  • Headache
  • Increased urination
  • Fatigue

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis)
  • Electrolyte disturbances (e.g., hyponatremia, hypokalemia)
  • Gout flare or pancreatitis

Precautions & Warnings

  • Before prescribing Nomexor Plus Hct, clinicians should consider several safety measures.
  • Blood pressure monitoring: ensure adequate control and avoid hypotension.
  • Electrolyte assessment: check sodium and potassium levels regularly.
  • Renal function evaluation: adjust use in patients with impaired kidney function.
  • Diabetes management: monitor blood glucose as thiazides may affect glucose tolerance.
  • Concomitant drug review: avoid use with lithium or other β‑blockers without supervision.
  • Store at room temperature: keep tablets in the original container, protect from moisture and light.

Avoid Interactions

Nomexor Plus Hct may interact with several medicines; some require avoidance while others need careful monitoring.

Major Interactions (Avoid)

  • Lithium: risk of lithium toxicity increases.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may reduce diuretic efficacy and impair renal function.
  • Other β‑blockers: additive bradycardia and hypotension.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may enhance hypotensive effect and potassium changes.
  • Digoxin: increased serum levels when combined with nebivolol.
  • Warfarin: possible alteration of anticoagulant effect.

Frequently Asked Questions

Nomexor Plus Hct is prescribed to lower high blood pressure in adult patients. It combines a thiazide diuretic with a beta‑blocker, providing dual mechanisms that help achieve target blood‑pressure levels in individuals diagnosed with hypertension.

Hydrochlorothiazide increases urine output by blocking sodium‑chloride reabsorption in the kidney, reducing fluid volume. Nebivolol selectively blocks β1‑adrenergic receptors, slowing heart rate and promoting nitric‑oxide‑mediated vasodilation. Together they lower peripheral resistance and cardiac output, resulting in a more pronounced antihypertensive effect.

The dose of Nomexor Plus Hct is individualized by the prescribing clinician based on the patient’s blood‑pressure readings, renal function, and overall health status. No fixed regimen is provided here; the prescriber will select the appropriate strength and frequency.

Safety data for hydrochlorothiazide and nebivolol in pregnancy and lactation are limited. The medication should only be used if the potential benefit justifies any potential risk to the fetus or infant, and it must be prescribed after a thorough risk‑benefit assessment by a healthcare professional.

To request Nomexor Plus Hct, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with single‑component agents, the combination of hydrochlorothiazide and nebivolol offers complementary mechanisms—diuresis and β‑blockade—allowing better blood‑pressure control in patients who need more than one class. It may reduce the number of pills required versus separate prescriptions, but individual response and tolerance vary.

Nomexor Plus Hct tablets should be stored at room temperature, below 25 °C, in their original packaging. Protect them from moisture, excessive heat and direct sunlight to maintain potency throughout the shelf life.

The medication is taken orally, usually with a glass of water. It is typically prescribed to be taken once daily, but the exact timing and whether it should be taken with food are determined by the prescribing clinician.

Serious risks include severe allergic reactions (anaphylaxis), significant electrolyte imbalances such as hyponatremia or hypokalemia, and rare occurrences of gout attacks or pancreatitis. Patients should seek immediate medical attention if they experience symptoms like swelling of the face, difficulty breathing, or severe abdominal pain.

Patients with known hypersensitivity to either hydrochlorothiazide or nebivolol, those with severe renal impairment, uncontrolled heart failure, or certain cardiac conduction disorders should avoid this medication. Additionally, individuals taking lithium or other β‑blockers without medical supervision should not use it.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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