Product image of Nomigrin (Naproxen Sodium, Sumatriptan Succinate) supplied by GNH India

Nomigrin

Active Ingredient:
Naproxen Sodium, Sumatriptan Succinate
Origin:
EU

Nomigrin (Naproxen Sodium, Sumatriptan Succinate)

Naproxen sodium and sumatriptan succinate, the active ingredients in Nomigrin, constitute an NSAID/Triptan combination presented as an oral tablet for oral administration. The product is indicated for the acute treatment of migraine attacks in adult patients, aiming to relieve headache and associated symptoms.

GNH India supplies Nomigrin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation to support global distribution. Customers benefit from reliable supply chains and responsive technical support.

Manufacturer / TM Owner

Orion Corporation

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

  • Nomigrin, a combined NSAID and triptan therapy, is used for the acute management of migraine.
  • Migraine without aura: rapid relief of headache and associated nausea.
  • Migraine with aura: reduction of aura severity and quicker resolution of headache.
  • Acute migraine attacks: alleviation of pain, photophobia, phonophobia and vomiting.

How It Works

  • Nomigrin combines sumatriptan succinate, a selective 5‑HT1B/1D receptor agonist that induces cranial vasoconstriction and inhibits release of pro‑inflammatory neuropeptides, with naproxen sodium, a non‑steroidal anti‑inflammatory drug that blocks cyclo‑oxygenase enzymes, reducing prostaglandin synthesis and neurogenic inflammation. The dual action targets both vascular and inflammatory components of migraine pathophysiology, providing faster and more sustained symptom relief.

Side Effects

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Dizziness: transient light‑headedness.
  • Dry mouth: reduced salivation.
  • Fatigue: feeling of tiredness.
  • Abdominal pain: mild discomfort.

Serious or Rare Side Effects

  • Cardiovascular events: chest pain, hypertension, or arrhythmia.
  • Serotonin syndrome: agitation, hyperthermia, muscle rigidity.
  • Severe allergic reaction: rash, swelling, airway compromise.
  • Hepatic dysfunction: jaundice or elevated liver enzymes.
  • Gastrointestinal bleeding: black stools or vomiting blood.

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Cardiovascular risk assessment: evaluate history of heart disease or uncontrolled hypertension.
  • Contraindication with uncontrolled hypertension: avoid use in patients with severe high blood pressure.
  • Caution with other NSAIDs: increased risk of gastrointestinal bleeding.
  • Avoid concomitant serotonergic agents: risk of serotonin syndrome.
  • Monitor for allergic reactions: discontinue if signs of hypersensitivity appear.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Nomigrin may interact with several drug classes. Review patient medication history carefully.

Major Interactions (Avoid)

  • MAO inhibitors: risk of severe serotonin syndrome.
  • Other triptans or ergot derivatives: additive vasoconstriction.
  • SSRIs/SNRIs or other serotonergic agents: heightened serotonin toxicity.
  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • CYP2C9 inhibitors (e.g., fluconazole): elevated naproxen levels.

Moderate Interactions (Monitor Closely)

  • Additional NSAIDs: cumulative gastrointestinal risk.
  • Antihypertensives: possible reduction in blood pressure control.
  • Oral contraceptives: may increase thrombotic risk.
  • Diuretics: potential renal function impact.
  • CYP3A4 inhibitors (e.g., erythromycin): modest increase in sumatriptan exposure.

Frequently Asked Questions

Nomigrin is prescribed for the acute treatment of migraine attacks in adults. It targets both the vascular and inflammatory mechanisms that cause migraine pain, helping to relieve headache, nausea, photophobia and phonophobia when taken at the onset of an attack.

Sumatriptan succinate activates 5‑HT1B/1D receptors, causing cranial blood‑vessel constriction and blocking release of pain‑triggering neuropeptides. Naproxen sodium inhibits cyclo‑oxygenase enzymes, reducing prostaglandin production and neurogenic inflammation. Together they provide rapid and sustained migraine relief.

The dosage of Nomigrin is determined by the prescribing healthcare professional based on the individual’s clinical condition, age, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

Safety data for Nomigrin during pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their physician before using this medication.

To place an order, submit an enquiry on the Nomigrin product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Nomigrin combines a triptan (sumatriptan) with an NSAID (naproxen), offering faster onset and longer‑lasting relief than either agent alone. Compared with sumatriptan monotherapy, the addition of naproxen reduces recurrence of headache, while the NSAID component adds anti‑inflammatory benefit not present in triptan‑only regimens.

Nomigrin should be stored at room temperature, below 25 °C, in its original packaging. Keep the tablets away from moisture, heat and direct sunlight to maintain product stability throughout its shelf life.

Nomigrin is taken orally as a tablet with a full glass of water. It is usually administered at the first sign of a migraine attack. Patients should not crush or chew the tablet unless specifically instructed by a healthcare professional.

Serious risks include cardiovascular events such as chest pain or hypertension, serotonin syndrome when combined with other serotonergic drugs, severe allergic reactions (rash, swelling, breathing difficulty), hepatic dysfunction, and gastrointestinal bleeding. Any of these symptoms require immediate medical attention.

Nomigrin is contraindicated in patients with known hypersensitivity to naproxen, sumatriptan, or any component of the formulation, those with uncontrolled hypertension, recent myocardial infarction or stroke, severe hepatic or renal impairment, and individuals taking MAO inhibitors or other triptans.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Naproxen Sodium, Sumatriptan Succinate

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT