Product image of Nomigrin (Naproxen Sodium, Sumatriptan Succinate) supplied by GNH India

Nomigrin

Active Ingredient:
Naproxen Sodium, Sumatriptan Succinate
Origin:
EU

Nomigrin (Naproxen Sodium, Sumatriptan Succinate)

Naproxen sodium and sumatriptan succinate, the active ingredients in Nomigrin, are an NSAID and 5‑HT1B/1D receptor agonist combination presented as an oral tablet for oral use. It treats acute migraine attacks in adults, providing rapid relief of headache and associated symptoms.

GNH India supplies Nomigrin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Orion Corporation

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Indications & Clinical Uses

Nomigrin is indicated for the acute treatment of migraine attacks, acting on inflammatory and vascular pathways.

  • Acute migraine attack: provides rapid relief of headache and associated symptoms.
  • Migraine with aura: aborts attacks when taken early in the aura phase.
  • Migraine without aura: reduces pain intensity and duration when administered at onset.

How It Works

  • Naproxen sodium inhibits cyclo‑oxygenase‑1 and ‑2 enzymes, decreasing prostaglandin synthesis and inflammation. Sumatriptan succinate selectively activates 5‑HT1B and 5‑HT1D receptors, causing cranial vasoconstriction and blocking release of pro‑inflammatory neuropeptides, thereby aborting migraine attacks.

Side Effects

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Dizziness: transient light‑headedness.
  • Dry mouth: reduced salivation.
  • Fatigue: feeling of tiredness.
  • Abdominal pain: mild discomfort.
  • Tingling sensation: peripheral paresthesia.

Serious or Rare Side Effects

  • Chest pain: possible cardiac ischemia.
  • Severe allergic reaction: rash, swelling, difficulty breathing.
  • Serotonin syndrome: agitation, hyperthermia, muscle rigidity.
  • Cardiovascular events: stroke or myocardial infarction.
  • Severe hypertension: sudden rise in blood pressure.
  • Hepatic injury: jaundice or abnormal liver tests.

Precautions & Warnings

Before prescribing Nomigrin, consider the following precautions:

  • Cardiovascular assessment: evaluate risk of ischemic heart disease.
  • Hypertension monitoring: avoid in uncontrolled high blood pressure.
  • Gastro‑intestinal safety: use caution in patients with ulcer disease.
  • Serotonergic drugs: monitor for signs of serotonin syndrome when combined with other serotonergic agents.
  • Pregnancy and lactation: avoid unless benefits outweigh potential risks.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Nomigrin may interact with several drug classes. Review patient medication history carefully.

Major Interactions (Avoid)

  • MAO inhibitors: risk of severe serotonin syndrome.
  • SSRIs, SNRIs, or other triptans: increased serotonin toxicity.
  • Anticoagulants (e.g., warfarin): enhanced bleeding risk.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may blunt antihypertensive effect.
  • Diuretics: possible additive blood pressure changes.

Frequently Asked Questions

Nomigrin is a prescription oral tablet that combines naproxen sodium and sumatriptan succinate to treat acute migraine attacks. It works to relieve headache pain and associated symptoms when taken at the onset of a migraine episode.

Naproxen sodium reduces inflammation by inhibiting cyclo‑oxygenase enzymes, lowering prostaglandin production. Sumatriptan succinate activates 5‑HT1B/1D receptors, causing cranial blood‑vessel constriction and blocking release of pain‑triggering neuropeptides, together aborting a migraine.

The specific dose and dosing schedule of Nomigrin are determined by the prescribing clinician based on the patient’s medical condition, severity of migraine, and other individual factors. Patients should follow the prescriber’s instructions exactly.

Safety data for Nomigrin in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order Nomigrin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and required import documentation.

Nomigrin combines an NSAID with a triptan, offering both anti‑inflammatory and vasoconstrictive actions. Compared with single‑agent triptans, it may provide faster pain relief and reduce the need for additional analgesics, while offering a different safety profile than NSAID‑only regimens.

Nomigrin tablets should be stored at ambient temperature, below 25 °C, in the original container to protect them from moisture and light. Keep the product out of reach of children.

Nomigrin is taken orally with a full glass of water. It is usually administered at the first sign of a migraine attack, as directed by a healthcare professional. Swallow the tablet whole; do not crush or chew.

Serious risks include cardiovascular events such as chest pain, stroke, or myocardial infarction, severe allergic reactions, serotonin syndrome when combined with other serotonergic drugs, and significant hypertension. Patients should seek immediate medical attention if these occur.

Nomigrin is contraindicated in patients with known hypersensitivity to naproxen, sumatriptan, or any component of the formulation, as well as those with uncontrolled hypertension, recent myocardial infarction, severe coronary artery disease, or who are taking MAO inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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