Non-Drowsy Sinutab (Pseudoephedrine Hydrochloride, Paracetamol)

Non‑Drowsy Sinutab combines a decongestant and an analgesic to treat common cold and flu symptom clusters.

• Nasal congestion: reduces swelling of nasal mucosa, improving airflow.
• Headache: alleviates pain associated with sinus pressure and tension.
• Fever: lowers elevated body temperature linked to viral infections.
• General cold‑and‑flu symptoms: provides combined relief of discomfort, allowing better daily functioning.

• Pseudoephedrine hydrochloride acts as an alpha‑adrenergic agonist, causing vasoconstriction of the nasal mucosal blood vessels and thereby decreasing congestion. Paracetamol exerts analgesic and antipyretic effects primarily through central inhibition of cyclooxygenase enzymes and modulation of the endocannabinoid system, resulting in reduced pain perception and fever.

Like all medicines, Non‑Drowsy Sinutab may cause unwanted reactions.

Common Side Effects

• Nausea: mild stomach upset that usually resolves on its own.
• Dizziness: transient light‑headedness, especially when standing quickly.
• Insomnia: difficulty falling asleep, often related to the stimulant effect of pseudoephedrine.
• Dry mouth: reduced salivation leading to a parched feeling.
• Headache: may persist despite the analgesic component.
• Palpitations: sensation of rapid or irregular heartbeat.

Serious or Rare Side Effects

• High blood pressure: significant rise in systolic or diastolic values.
• Cardiac arrhythmia: abnormal heart rhythm that may require medical attention.
• Severe allergic reaction: rash, swelling, or difficulty breathing (anaphylaxis).
• Liver injury: rare but possible elevation of liver enzymes or hepatitis.

Before using Non‑Drowsy Sinutab, consider the following safety measures.

• Cardiovascular assessment: evaluate patients with hypertension or heart disease before use.
• Drug‑interaction review: check for concomitant sympathomimetic or MAO‑inhibitor therapy.
• Age limitation: avoid use in children under the age specified by local regulations.
• Underlying conditions: use caution in patients with diabetes, thyroid disorders, or prostate enlargement.
• Alcohol consumption: limit intake as it may increase hepatic load.
• Store at ambient temperature: keep below 25 °C, in the original packaging, protected from moisture and direct sunlight.

Non‑Drowsy Sinutab can affect or be affected by other medicines. Major Interactions (Avoid):\n- Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis.

• Other sympathomimetic agents (e.g., phenylephrine): may cause excessive vasoconstriction and elevated blood pressure.
• Certain antidepressants (e.g., tricyclics): increase risk of cardiovascular side effects.

Moderate Interactions (Monitor Closely)

• Antihypertensive drugs (beta‑blockers, ACE inhibitors): pseudoephedrine may reduce their efficacy.
• Alcohol or other hepatotoxic agents: combined use can increase liver stress.
• NSAIDs: concurrent use may raise risk of renal impairment, especially in dehydrated patients.