Product image of Nonivamid + Nicoboxil Opella Healthcare (Nicoboxil, Nonivamide) supplied by GNH India

Nonivamid + Nicoboxil Opella Healthcare

Active Ingredient:
Nicoboxil, Nonivamide
Origin:
EU

Nonivamid + Nicoboxil Opella Healthcare (Nicoboxil, Nonivamide)

Nicoboxil and Nonivamide, the active ingredients in Nonivamid + Nicoboxil Opella Healthcare, are topical analgesics presented as a topical formulation for external use. They provide temporary relief of musculoskeletal pain in adults and act as counter‑irritants that produce a warming sensation and increase local blood flow, helping to mask pain signals from muscles, joints and the back.

GNH India supplies Nonivamid + Nicoboxil Opella Healthcare as a licensed, GDP‑compliant international pharmaceutical supplier serving pharmacies and clinics worldwide. The company adheres to Good Distribution Practice and provides regulatory‑compliant shipments to health‑care providers across multiple continents.

Manufacturer / TM Owner

Zentiva, K.S.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Nonivamid + Nicoboxil is a topical counter‑irritant used to manage pain in the musculoskeletal system.

  • Muscle pain: provides temporary relief of discomfort in skeletal muscles.
  • Joint pain: eases aching and stiffness in articulations.
  • Back pain: reduces localized pain in the lumbar region.
  • Sports‑related injuries: alleviates soreness and minor strains from athletic activity.

How It Works

  • Nicoboxil and Nonivamide activate transient receptor potential vanilloid 1 (TRPV1) receptors on peripheral sensory neurons, inducing a counter‑irritant effect and vasodilation. This leads to increased local blood flow and a warming sensation that distracts the central nervous system from nociceptive signals, thereby reducing the perception of musculoskeletal pain.

Side Effects

Topical application of Nonivamid + Nicoboxil may cause skin‑related reactions, ranging from mild to severe.

Common Side Effects

  • Skin irritation: mild redness or discomfort at the application site.
  • Burning sensation: transient warmth or tingling feeling.
  • Itching: mild pruritus localized to the treated area.
  • Dryness: occasional flaking or dryness of the skin.

Serious or Rare Side Effects

  • Allergic reaction: hives, swelling, or severe rash.
  • Severe dermatitis: blistering or extensive skin inflammation.
  • Contact urticaria: rapid onset of swelling and itching after contact.

Precautions & Warnings

When using Nonivamid + Nicoboxil, follow these safety measures.

  • Avoid application on broken or irritated skin: do not apply to open wounds or eczema.
  • Do not use under occlusive dressings: may increase absorption and irritation.
  • Limit exposure to sun or UV light after application: product may increase photosensitivity.
  • Discontinue use if severe irritation develops: seek medical advice.
  • Store at room temperature below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Nonivamid + Nicoboxil may interact with other substances applied to the skin.

Major Interactions (Avoid)

  • Concurrent use with other topical counter‑irritants: increased risk of skin irritation.
  • Application with strong vasodilators: may potentiate local hypotensive effects.

Moderate Interactions (Monitor Closely)

  • Use with alcohol‑based skin cleansers: may enhance drug absorption.
  • Combination with phototherapy or UV treatments: could raise photosensitivity.
  • Co‑application with topical steroids: may alter anti‑inflammatory response.

Frequently Asked Questions

Nonivamid + Nicoboxil is a topical analgesic formulated to relieve mild to moderate musculoskeletal discomfort. It is commonly applied to areas of muscle pain, joint aches, back strain, and minor sports‑related injuries to provide temporary symptom relief through a counter‑irritant effect.

Nicoboxil activates TRPV1 receptors on peripheral sensory nerves, creating a warming sensation and vasodilation. This counter‑irritant response diverts pain signals and increases local blood flow, which together help reduce the perception of pain in the treated area.

The appropriate amount and frequency of application are determined by the prescribing health‑care professional. Typically, a thin layer is spread over the affected skin area and gently massaged in, but exact dosing instructions should follow the prescriber’s guidance.

Safety data for use in pregnancy or while breastfeeding are limited. Women who are pregnant, planning a pregnancy, or nursing should discuss potential risks with their health‑care provider before using this product.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with non‑steroidal anti‑inflammatory gels such as diclofenac, Nonivamid + Nicoboxil works primarily through a counter‑irritant mechanism rather than cyclo‑oxygenase inhibition. This can result in a warming sensation and rapid onset of pain relief, but it does not provide the anti‑inflammatory effects of NSAID‑based products.

Store the product at room temperature below 25 °C, in its original container, protected from moisture and direct sunlight. Keep the tube tightly closed when not in use and out of reach of children.

Apply a thin layer of the gel to clean, dry skin over the painful area. Gently massage until fully absorbed. Avoid covering the treated skin with airtight dressings unless directed by a health‑care professional.

Serious adverse reactions, although rare, include severe allergic responses such as hives, swelling, or extensive dermatitis. If any signs of a systemic allergic reaction or severe skin irritation occur, discontinue use immediately and seek medical attention.

Individuals with known hypersensitivity to Nicoboxil, Nonivamide, or any excipients in the formulation should avoid use. It should also not be applied to broken, inflamed, or infected skin, and should be used with caution in patients with severe dermatological conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.