Product image of Nontoss (Butamirate Citrate) supplied by GNH India

Nontoss

Active Ingredient:
Butamirate Citrate
Origin:
EU

Nontoss (Butamirate Citrate)

Butamirate Citrate, the active ingredient in Nontoss, is a cough suppressant presented as an oral dosage form for oral use. It treats dry (non‑productive) cough in adults and children.
GNH India supplies Nontoss as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Cooper Pharmaceuticals S.A.

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Indications & Clinical Uses

Butamirate Citrate is an antitussive that acts on the cough centre to reduce irritation‑driven coughing.

  • Dry (non‑productive) cough: decreases cough frequency and intensity.
  • Cough associated with common cold: provides symptomatic relief without affecting mucus clearance.
  • Throat irritation‑related cough: suppresses the cough reflex caused by mild airway irritation.

How It Works

  • Butamirate citrate suppresses the cough reflex by acting on the cough centre in the medulla oblongata. Although the precise molecular target is not fully defined, it modulates neuronal activity that initiates coughing, leading to reduced cough frequency and severity without significant effect on respiratory secretions.

Side Effects

Butamirate citrate is generally well tolerated, but some patients may experience adverse reactions.

Common Side Effects

  • Drowsiness: mild sleepiness reported in some users.
  • Nausea: occasional upset stomach.
  • Dry mouth: reduced salivation.
  • Dizziness: transient light‑headedness.
  • Headache: mild to moderate.
  • Gastrointestinal discomfort: mild abdominal pain or bloating.

Serious or Rare Side Effects

  • Allergic reactions: rash, itching, or angioedema.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Hepatic dysfunction: abnormal liver enzymes.
  • Neutropenia: reduced white blood cell count.
  • Anaphylaxis: rapid onset of systemic allergic response.

Precautions & Warnings

When using butamirate citrate, consider the following safety measures.

  • Use in children: follow prescriber guidance and age‑appropriate dosing.
  • Known hypersensitivity: avoid if allergic to butamirate or excipients.
  • Concomitant CNS depressants: use with caution as additive sedation may occur.
  • Hepatic impairment: monitor liver function and adjust use if needed.
  • Duration of therapy: do not exceed the prescribed treatment period without medical advice.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Butamirate citrate may interact with other substances that affect the central nervous system or metabolism.

Major Interactions (Avoid)

  • Alcohol: can enhance sedative effects and increase drowsiness.
  • Opioid analgesics: additive CNS depression may occur.
  • Benzodiazepines: risk of excessive sedation.

Moderate Interactions (Monitor Closely)

  • Antihistamines: may increase anticholinergic side effects such as dry mouth.
  • Anticholinergic agents: monitor for enhanced dryness and constipation.

Frequently Asked Questions

Nontoss contains butamirate citrate, an over‑the‑counter antitussive indicated for the temporary relief of dry (non‑productive) cough associated with common colds, throat irritation, or other minor respiratory conditions.

Butamirate citrate acts on the cough centre in the medulla oblongata, modulating neuronal pathways that trigger the cough reflex. This reduces the frequency and intensity of coughing without significantly affecting mucus production.

The appropriate dose of Nontoss is determined by a qualified healthcare professional based on the patient’s age, weight, and clinical condition. Patients should follow the prescriber’s instructions and the product label.

The safety of butamirate citrate in pregnancy and lactation has not been definitively established. Women who are pregnant, planning to become pregnant, or breastfeeding should consult their healthcare provider before using Nontoss.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with codeine‑based antitussives, butamirate citrate offers cough relief without opioid‑related dependence risk. It is also non‑sedating relative to some antihistamine‑based cough medicines, making it suitable for patients who need to remain alert.

Store Nontoss at room temperature, below 25 °C, in the original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use after the expiry date.

Nontoss is taken orally, usually with a glass of water. The tablet should be swallowed whole and not chewed or crushed unless otherwise directed by a healthcare professional.

Serious but rare risks include allergic reactions such as rash, angioedema, or anaphylaxis, as well as severe skin reactions like Stevens‑Johnson syndrome. Any signs of hypersensitivity require immediate medical attention.

Individuals with known hypersensitivity to butamirate citrate or any excipients, patients taking strong central nervous system depressants without medical supervision, and those with severe hepatic impairment should avoid using Nontoss unless advised otherwise by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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