Product image of Nopregy (Levonorgestrel) supplied by GNH India

Nopregy

Active Ingredient:
Levonorgestrel
Origin:
EU

Nopregy (Levonorgestrel)

Levonorgestrel, the active ingredient in Nopregy, is a progestin presented as an oral tablet for oral use. It is employed to prevent or delay ovulation and to provide emergency contraception after unprotected sexual intercourse.

GNH India supplies Nopregy as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Medreg S.R.O.

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Indications & Clinical Uses

Levonorgestrel acts within the hormonal contraceptive pathway to prevent unintended pregnancy.

  • Emergency contraception: provides post‑coital protection when taken promptly after unprotected intercourse.
  • Prevention of unintended pregnancy: used as a single dose to reduce the risk of pregnancy following contraceptive failure.
  • Ovulation inhibition (as part of emergency regimen): suppresses the release of an egg to avoid fertilisation.

How It Works

  • Levonorgestrel binds to progesterone receptors in the hypothalamic‑pituitary‑ovarian axis, inhibiting the luteinising hormone surge required for ovulation. It also alters tubal motility and modifies the endometrial lining, creating conditions that are unfavorable for implantation of a fertilised egg.

Side Effects

Levonorgestrel is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Nausea
  • Headache
  • Fatigue
  • Dizziness
  • Abdominal pain
  • Menstrual changes

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis)
  • Thromboembolic events
  • Liver dysfunction

Precautions & Warnings

Levonorgestrel should be used with awareness of specific safety considerations.

  • Timing of administration: take as soon as possible, ideally within 72 hours after unprotected intercourse.
  • Contraindications: avoid if known hypersensitivity to levonorgestrel or other progestins.
  • Medical conditions: caution in women with a history of thromboembolic disorders, liver disease, or hormone‑sensitive cancers.
  • Drug interactions: review concomitant medications that may reduce efficacy.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levonorgestrel may interact with other medicines, altering its effectiveness.

Major Interactions (Avoid)

  • Enzyme inducers such as rifampicin, which can lower plasma levels.
  • Anticonvulsants like carbamazepine that accelerate metabolism.
  • St. John’s wort, a herbal inducer of CYP3A4.

Moderate Interactions (Monitor Closely)

  • Hormonal therapies (e.g., combined oral contraceptives) that may have additive hormonal effects.
  • Antifungal azoles (e.g., ketoconazole) that can affect hormone metabolism.
  • Certain antiretrovirals (e.g., protease inhibitors) that may modify drug levels.

Frequently Asked Questions

Nopregy contains levonorgestrel and is used as an oral emergency contraceptive to reduce the risk of pregnancy after unprotected sexual intercourse or contraceptive failure.

Levonorgestrel binds to progesterone receptors, preventing the luteinising hormone surge needed for ovulation, altering tubal motility, and changing the endometrial lining to make implantation unlikely.

The specific dose and regimen of Nopregy are determined by the prescribing healthcare professional based on clinical guidelines and the timing of administration.

Nopregy is intended to prevent pregnancy and is not used during an established pregnancy. Its safety during breastfeeding has not been fully established, so use should follow a prescriber's advice.

Enquiries are submitted via the product page on gnhindia.com, where you specify the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Nopregy delivers levonorgestrel, a well‑studied progestin. Compared with ulipristal acetate, another emergency option, levonorgestrel is most effective when taken within 72 hours and has a slightly shorter window of efficacy but is widely available and inexpensive.

Store Nopregy at ambient temperature, below 25 °C, in its original packaging. Keep the tablets away from moisture, heat and direct sunlight to maintain potency.

Nopregy is taken orally, usually as a single tablet. The prescriber will advise the exact timing relative to the unprotected intercourse event.

Serious but rare risks include severe allergic reactions, thromboembolic events and liver dysfunction. Any signs of rash, swelling, difficulty breathing, chest pain or jaundice should prompt immediate medical attention.

Women with known hypersensitivity to levonorgestrel or other progestins, those with active thromboembolic disease, severe liver impairment, or certain hormone‑sensitive cancers should avoid using Nopregy, unless a healthcare professional determines it is appropriate.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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