Product image of Noprilam 500 (Amoxicillin, Clavulanic Acid) supplied by GNH India

Noprilam 500

Active Ingredient:
Amoxicillin, Clavulanic Acid
Origin:
EU

Noprilam 500 (Amoxicillin, Clavulanic Acid)

Amoxicillin, the active ingredient in Noprilam 500, is a Penicillin beta-lactam antibiotic presented as an oral tablet for systemic use. It treats bacterial infections in adults and children.
GNH India supplies Noprilam 500 as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bial - Portela & Cª , Sa

1
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Indications & Clinical Uses

Amoxicillin/Clavulanic acid is used to treat infections caused by susceptible bacteria across several organ systems.

  • Upper respiratory tract infections: effective against sinusitis, otitis media, and pharyngitis.
  • Lower respiratory tract infections: treats community‑acquired pneumonia and exacerbations of chronic bronchitis.
  • Skin and soft‑tissue infections: resolves cellulitis and wound infections.
  • Urinary tract infections: clears uncomplicated cystitis.

How It Works

  • Amoxicillin inhibits bacterial cell‑wall synthesis by binding to penicillin‑binding proteins, leading to cell lysis. Clavulanic acid acts as a β‑lactamase inhibitor, protecting amoxicillin from enzymatic degradation and extending its antibacterial spectrum against β‑lactamase‑producing organisms.

Side Effects

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Diarrhea: may be watery or loose.
  • Rash: mild skin erythema or itching.
  • Vomiting: occasional emesis.
  • Taste disturbance: altered taste perception.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Clostridioides difficile‑associated diarrhea: potentially life‑threatening colitis.
  • Stevens‑Johnson syndrome: rare severe skin reaction.
  • Hepatic enzyme elevation: possible liver function abnormalities.
  • Neutropenia: reduced white blood cell count.

Precautions & Warnings

Before prescribing Noprilam 500, consider the following safety measures.

  • Allergy assessment: avoid in patients with known hypersensitivity to penicillins or clavulanic acid.
  • Renal function: dose adjustment may be required in severe impairment.
  • Hepatic function: monitor liver enzymes during prolonged therapy.
  • Concomitant oral contraceptives: efficacy may be reduced; advise alternative contraception.
  • Use in pregnancy: only if clearly needed after risk‑benefit evaluation.
  • Store at room temperature: keep in the original pack, protect from moisture and heat.

Avoid Interactions

Drug‑drug interactions can affect efficacy or safety of Noprilam 500.

Major Interactions (Avoid)

  • Probenecid: may increase amoxicillin plasma levels.
  • Methotrexate: risk of heightened toxicity.
  • Warfarin: potential enhancement of anticoagulant effect.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: reduced effectiveness, consider backup method.
  • Allopurinol: possible rash development.
  • Ciprofloxacin: antagonistic effect reducing antibacterial activity.

Frequently Asked Questions

Noprilam 500 contains amoxicillin and clavulanic acid, a combination used to treat a variety of bacterial infections such as respiratory, skin, urinary and ear‑nose‑throat infections when the causative organisms are susceptible.

Amoxicillin blocks bacterial cell‑wall synthesis by binding to penicillin‑binding proteins, causing cell lysis. Clavulanic acid inhibits β‑lactamase enzymes produced by some bacteria, protecting amoxicillin from degradation and broadening its antibacterial coverage.

The specific dose and duration are determined by the prescribing clinician based on the infection type, severity, patient age, weight and renal function. Patients should follow the prescriber’s instructions exactly.

Safety data are limited; the product should only be used during pregnancy or lactation when clearly needed and after a risk‑benefit assessment by the healthcare provider.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and required import documentation.

Compared with plain amoxicillin, the addition of clavulanic acid extends activity against β‑lactamase‑producing bacteria, making Noprilam 500 effective for infections where resistance to amoxicillin alone is common.

Store the tablets at room temperature, below 25 °C, in the original packaging. Keep them away from moisture and direct sunlight to maintain stability.

Noprilam 500 is taken orally, usually with a full glass of water. It may be taken with or without food, but taking it with food can reduce gastrointestinal upset.

Serious risks include severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated colitis, and rare skin reactions like Stevens‑Johnson syndrome. Immediate medical attention is required if any of these occur.

Patients with a known hypersensitivity to penicillins, clavulanic acid, or any component of the formulation should avoid Noprilam 500. Caution is also advised in individuals with severe renal impairment until a clinician evaluates suitability.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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