Product image of Noqturina (Desmopressin) supplied by GNH India

Noqturina

Active Ingredient:
Desmopressin
Origin:
EU

Noqturina (Desmopressin)

Desmopressin, the active ingredient in Noqturina, is a vasopressin analog presented as an oral dosage form for oral administration. It selectively stimulates renal V2 receptors, enhancing water reabsorption and reducing urine output, and is indicated for central diabetes insipidus, nocturnal enuresis in children, and selected bleeding disorders such as mild hemophilia A and von Willebrand disease.

GNH India supplies Noqturina as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides regulatory documentation for global distribution.

Manufacturer / TM Owner

Ferring Ireland Ltd.

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Indications & Clinical Uses

Desmopressin acts on the antidiuretic pathway and coagulation management, providing therapeutic benefit in several conditions.

  • Central diabetes insipidus: reduces excessive urine output by increasing water reabsorption in the kidneys.
  • Nocturnal enuresis: decreases nighttime bedwetting episodes by concentrating urine.
  • Mild hemophilia A: raises plasma factor VIII levels to improve clot formation.
  • Von Willebrand disease: enhances von Willebrand factor release, supporting hemostasis.

How It Works

  • Desmopressin is a synthetic analogue of vasopressin that binds selectively to V2 receptors on the basolateral membrane of renal collecting‑duct cells. Activation of these G‑protein‑coupled receptors stimulates adenylate cyclase, increasing intracellular cAMP, which promotes insertion of aquaporin‑2 water channels into the apical membrane, thereby increasing water reabsorption. In hemostasis, it triggers release of stored von Willebrand factor and factor VIII from endothelial cells.

Side Effects

Desmopressin may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Nausea: occasional upset stomach.
  • Nasal congestion: sensation of blocked nose.
  • Mild hyponatremia: low sodium without severe symptoms.

Serious or Rare Side Effects

  • Severe hyponatremia: can cause seizures or coma.
  • Water intoxication: excessive fluid retention leading to edema.
  • Thromboembolic events: rare clot formation.
  • Allergic reactions: rash, itching, or anaphylaxis.

Precautions & Warnings

Before initiating Noqturina, several safety considerations should be observed.

  • Monitor sodium: check serum sodium regularly, especially in patients at risk of hyponatremia.
  • Fluid restriction: limit fluid intake to ≤1.5 L/day during treatment to prevent water overload.
  • Renal function: assess kidney function before initiating therapy.
  • Concomitant drugs: avoid simultaneous use of other antidiuretic agents unless medically justified.
  • Pregnancy and lactation: use only if benefits outweigh risks; consult healthcare provider.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture.

Avoid Interactions

Desmopressin can interact with several medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • NSAIDs: may potentiate antidiuretic effect and increase hyponatremia risk.
  • Carbamazepine: can reduce desmopressin efficacy by increasing renal clearance.
  • Diuretics (especially thiazides): synergistic effect on water retention leading to hyponatremia.
  • Anticoagulants (e.g., warfarin): may enhance bleeding risk when used for hemostatic indications.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: may modestly increase risk of hyponatremia.
  • SSRIs: combined use can raise hyponatremia potential.
  • Alcohol: may exacerbate fluid balance disturbances.

Frequently Asked Questions

Noqturina contains desmopressin, which is prescribed to manage central diabetes insipidus, reduce nocturnal enuresis (bedwetting) in children, and treat certain bleeding disorders such as mild hemophilia A and von Willebrand disease by enhancing water reabsorption and supporting clotting factor release.

Desmopressin mimics the natural hormone vasopressin and binds selectively to V2 receptors in the kidney collecting ducts. This activation raises intracellular cAMP, causing aquaporin‑2 channels to move to the cell surface, which increases water reabsorption and concentrates urine. In hemostasis, it stimulates endothelial cells to release von Willebrand factor and factor VIII.

The appropriate dose of Noqturina is individualized by the prescribing healthcare professional based on the patient’s age, weight, renal function, severity of the condition, and response to therapy. No standard dosing regimen is provided here; the prescriber will set the exact amount and frequency.

Safety data for desmopressin during pregnancy and lactation are limited. It should only be used when the potential benefit justifies any potential risk to the fetus or infant. Healthcare providers will evaluate the risk‑benefit profile for each patient and advise accordingly.

To order Noqturina, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets. After the request, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details and any necessary import documentation.

The primary alternative to desmopressin is natural vasopressin (Pitressin) or older antidiuretic agents such as chlorpropamide. Desmopressin offers a longer half‑life, greater selectivity for V2 receptors, and a lower risk of vasoconstrictive side effects compared with vasopressin, while providing more predictable antidiuretic and hemostatic effects than chlorpropamide.

Noqturina should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging to protect it from moisture and light. Do not store in a refrigerator or freezer unless the manufacturer specifies otherwise.

Noqturina is taken orally, usually with a glass of water. The tablet or oral solution should be swallowed whole unless the prescriber advises otherwise. It may be taken with or without food, but patients should follow the specific instructions provided by their healthcare professional.

The most serious risks include severe hyponatremia, which can lead to seizures, coma, or death, and water intoxication resulting in cerebral edema. Patients should be alert for sudden headache, nausea, vomiting, confusion, or swelling, and should seek immediate medical attention if these symptoms occur.

Noqturina is contraindicated in individuals with known hypersensitivity to desmopressin or any component of the formulation, in patients with uncontrolled hyponatremia, and in those with severe renal impairment where water balance cannot be safely managed. It should also be avoided in patients taking other potent antidiuretic agents unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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