Product image of Noradox (Doxazosin Mesilate) supplied by GNH India

Noradox

Active Ingredient:
Doxazosin Mesilate
Origin:
EU

Noradox (Doxazosin Mesilate)

Doxazosin mesilate, the active ingredient in Noradox, is an alpha-1 adrenergic blocker presented as an oral tablet for oral use. It is indicated for the management of hypertension and for relief of lower urinary tract symptoms associated with benign prostatic hyperplasia in adult patients.

GNH India supplies Noradox as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Errekappa Euroterapici Spa

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Indications & Clinical Uses

Doxazosin mesilate acts on the alpha‑1 adrenergic receptor pathway to lower blood pressure and relax prostatic smooth muscle.

  • Hypertension: reduces systemic vascular resistance, helping to achieve target blood pressure levels.
  • Benign prostatic hyperplasia (BPH): eases urinary obstruction by decreasing smooth‑muscle tone in the prostate and bladder neck.
  • Lower urinary tract symptoms (LUTS) associated with BPH: improves urinary flow and reduces urgency and frequency.

How It Works

  • Doxazosin mesilate selectively and reversibly antagonizes alpha‑1 adrenergic receptors on vascular smooth muscle and in the prostate. Blockade of these receptors leads to vasodilation, lowering peripheral resistance and blood pressure, while also reducing smooth‑muscle tone in the prostate and bladder neck, facilitating urine flow.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Dizziness or light‑headedness, especially after the first dose.
  • Headache.
  • Fatigue or tiredness.
  • Nasal congestion.
  • Swelling of the ankles or feet.
  • Nausea.

Serious or Rare Side Effects

  • Severe hypotension or syncope.
  • Heart failure exacerbation.
  • Liver enzyme elevations.
  • Priapism.
  • Allergic reactions such as rash, itching, or angioedema.
  • Persistent erectile dysfunction.

Precautions & Warnings

Before initiating therapy, consider patient‑specific factors and monitor for potential risks.

  • Cardiovascular status: assess for orthostatic hypotension, especially in the elderly.
  • Renal or hepatic impairment: dose adjustment may be required.
  • Concomitant antihypertensives: monitor for additive blood‑pressure lowering effects.
  • History of priapism: avoid use due to risk of recurrence.
  • Pregnancy and lactation: safety not established; use only if clearly needed.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, and protect from moisture.

Avoid Interactions

Doxazosin mesilate may interact with several drug classes; clinical monitoring is advised. Major Interactions (Avoid):\n- Phosphodiesterase‑5 inhibitors (e.g., sildenafil): can cause profound hypotension.

  • Other alpha‑blockers: additive vasodilatory effect may lead to severe hypotension.

Moderate Interactions (Monitor Closely)

  • Diuretics: may increase risk of orthostatic hypotension.
  • Antihypertensive agents (ACE inhibitors, ARBs, beta‑blockers): may require dose adjustments.
  • CYP3A4 inhibitors (e.g., ketoconazole): may raise plasma levels of doxazosin.

Frequently Asked Questions

Noradox contains doxazosin mesilate, which is prescribed to lower high blood pressure and to relieve urinary symptoms caused by benign prostatic hyperplasia. It helps control hypertension and improves urine flow in men with an enlarged prostate.

Doxazosin mesilate selectively blocks alpha‑1 adrenergic receptors on blood vessels and prostate smooth muscle. This blockade causes blood vessels to relax, reducing peripheral resistance and blood pressure, while also decreasing muscle tone in the prostate and bladder neck to ease urinary obstruction.

The appropriate dose of Noradox is determined by the prescribing healthcare professional based on the individual’s medical condition, response to therapy, and any other medications being taken. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for doxazosin mesilate in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To request Noradox, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Noradox belongs to the alpha‑1 blocker class, offering both blood‑pressure reduction and prostate smooth‑muscle relaxation. Compared with beta‑blockers, it does not affect heart rate, and unlike 5‑alpha‑reductase inhibitors, it provides quicker relief of urinary symptoms but does not shrink prostate size.

Noradox should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and keep them out of reach of children.

Noradox is taken orally, usually once daily with or without food. The tablet should be swallowed whole with a glass of water. Patients should follow the dosing schedule prescribed by their healthcare professional.

Serious risks include severe hypotension, syncope, heart failure worsening, and rare cases of priapism or allergic reactions such as rash or angioedema. Patients should seek immediate medical attention if they experience fainting, chest pain, persistent swelling, or any signs of an allergic response.

Noradox is contraindicated in patients with known hypersensitivity to doxazosin or any component of the formulation, and it should be used with caution in individuals with severe liver disease, uncontrolled heart failure, or a history of priapism. Pregnant or breastfeeding women should only use it if clearly indicated by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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