Product image of Noradrenalin Aguettant (Noradrenaline Tartrate) supplied by GNH India

Noradrenalin Aguettant

Active Ingredient:
Noradrenaline Tartrate
Origin:
EU

Noradrenalin Aguettant (Noradrenaline Tartrate)

Noradrenaline Tartrate, the active ingredient in Noradrenalin Aguettant, is a catecholamine vasopressor presented as an injectable solution for intravenous use. It treats hypotension, septic shock, cardiogenic shock, and cardiac arrest in acute care settings.

GNH India supplies Noradrenalin Aguettant as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Laboratoire Aguettant

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Indications & Clinical Uses

Noradrenalin Aguettant, a catecholamine vasopressor, is employed in critical care to restore vascular tone and support cardiac output.

  • Hypotension: raises blood pressure by inducing peripheral vasoconstriction.
  • Septic shock: improves organ perfusion by increasing systemic vascular resistance.
  • Cardiogenic shock: enhances myocardial contractility and systemic pressure.
  • Cardiac arrest: provides circulatory support during resuscitation efforts.

How It Works

  • Noradrenaline Tartrate is rapidly converted to noradrenaline after intravenous administration. The drug acts as an agonist at alpha‑1 adrenergic receptors, producing potent vasoconstriction, and also stimulates beta‑1 receptors, increasing heart rate and myocardial contractility, thereby elevating arterial pressure and cardiac output in shock states.

Side Effects

Noradrenalin Aguettant may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Tachycardia: rapid heart rate due to beta‑1 stimulation.
  • Hypertension: elevated blood pressure from alpha‑1 mediated vasoconstriction.
  • Headache: secondary to increased vascular tone.
  • Nausea: gastrointestinal discomfort during infusion.

Serious or Rare Side Effects

  • Myocardial ischemia: reduced coronary blood flow from excessive vasoconstriction.
  • Severe hypertension: dangerously high arterial pressure.
  • Tissue necrosis at infusion site: extravasation leading to local injury.
  • Anaphylaxis: rare systemic allergic reaction.

Precautions & Warnings

When using Noradrenalin Aguettant, clinicians should observe several safety measures.

  • Cardiovascular monitoring: continuously assess blood pressure and heart rate.
  • Dose titration: adjust infusion rate to achieve target hemodynamics.
  • Contraindication in pheochromocytoma: avoid use due to risk of hypertensive crisis.
  • Caution in myocardial ischemia: monitor for signs of reduced coronary perfusion.
  • Avoid extravasation: ensure proper IV line placement and inspect site regularly.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Noradrenalin Aguettant can interact with other agents that affect the sympathetic nervous system.

Major Interactions (Avoid)

  • MAO inhibitors: may cause hypertensive emergencies.
  • Tricyclic antidepressants: additive pressor effects.
  • Sympathomimetic drugs: risk of severe hypertension.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may blunt desired tachycardia.
  • Calcium channel blockers: potential additive hypotensive effects after dose reduction.

Frequently Asked Questions

Noradrenalin Aguettant is an injectable catecholamine vasopressor used in acute care to treat severe hypotension, septic shock, cardiogenic shock, and to provide circulatory support during cardiac arrest. It works by raising blood pressure and improving cardiac output in critically ill patients.

After intravenous administration, Noradrenaline Tartrate is converted to noradrenaline, which activates alpha‑1 adrenergic receptors causing vasoconstriction and beta‑1 receptors increasing heart rate and contractility. This dual action raises systemic vascular resistance and cardiac output, helping restore adequate perfusion in shock states.

The dosage of Noradrenalin Aguettant is individualized and set by the prescribing clinician based on the patient’s hemodynamic status, target blood pressure, and response to therapy. Dosing is typically titrated in micrograms per minute via continuous intravenous infusion.

The safety of Noradrenalin Aguettant in pregnancy and lactation has not been established. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by the treating physician.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Noradrenalin Aguettant is the first‑line catecholamine vasopressor for most shock states due to its balanced alpha‑1 and beta‑1 activity. Compared with agents like dopamine or phenylephrine, it offers more predictable blood pressure control with fewer arrhythmic risks, making it the preferred choice in many guidelines.

The product should be stored at 2‑8 °C, protected from light, and must not be frozen or shaken. Prior to use, inspect the solution for particulate matter and ensure the vial is within the expiry date. Maintain cold‑chain conditions during transport.

Noradrenalin Aguettant is administered intravenously as a continuous infusion. The solution is diluted in a compatible carrier fluid and infused through a dedicated line with a calibrated infusion pump, allowing precise titration to achieve the desired hemodynamic response.

Serious risks include severe hypertension, myocardial ischemia, tissue necrosis from extravasation, and rare anaphylactic reactions. Continuous cardiovascular monitoring and careful infusion site inspection are essential to detect and manage these complications promptly.

Patients with known hypersensitivity to noradrenaline or any excipients, those with pheochromocytoma, or individuals in whom uncontrolled hypertension would pose a high risk should not receive Noradrenalin Aguettant. Contraindications must be evaluated by the treating physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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