Product image of Noradrenalin Aguettant (Noradrenaline Tartrate) supplied by GNH India

Noradrenalin Aguettant

Active Ingredient:
Noradrenaline Tartrate
Origin:
EU

Noradrenalin Aguettant (Noradrenaline Tartrate)

Noradrenaline tartrate, the active ingredient in Noradrenalin Aguettant, is a sympathomimetic catecholamine presented as an intravenous solution for intravenous use. It is employed to raise blood pressure in acute hypotensive states and to support circulation during shock and cardiac arrest.

GNH India supplies Noradrenalin Aguettant as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Laboratoire Aguettant

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Indications & Clinical Uses

  • Noradrenalin Aguettant acts on the sympathetic cardiovascular pathway to correct severe hypotension and shock.
  • Acute hypotension: rapidly increases systemic vascular resistance to restore arterial pressure.
  • Septic shock: supports perfusion when endogenous catecholamine response is insufficient.
  • Cardiac arrest: provides vasoconstriction and modest inotropic support during resuscitation.
  • Post‑operative hypotension: stabilises blood pressure after major surgery.

How It Works

  • Noradrenaline tartrate binds primarily to α1‑adrenergic receptors on vascular smooth muscle, producing potent vasoconstriction that raises systemic vascular resistance and arterial pressure. It also stimulates β1‑adrenergic receptors in the heart, leading to a modest increase in cardiac contractility and heart rate, thereby enhancing cardiac output during critical circulatory failure.

Side Effects

Adverse reactions may occur with intravenous administration of noradrenaline.

Common Side Effects

  • Headache: transient and dose‑related.
  • Tachycardia: increased heart rate due to β1 stimulation.
  • Peripheral ischemia: reduced blood flow to extremities.
  • Nausea: mild gastrointestinal upset.
  • Anxiety: feeling of restlessness or nervousness.

Serious or Rare Side Effects

  • Cardiac arrhythmias: potentially life‑threatening rhythm disturbances.
  • Severe hypertension: excessive rise in blood pressure.
  • Tissue necrosis: from extravasation at the infusion site.
  • Myocardial ischemia: reduced coronary perfusion.
  • Pulmonary edema: fluid accumulation in lungs.

Precautions & Warnings

  • Noradrenalin Aguettant requires careful monitoring and specific safety measures.
  • Blood pressure monitoring: continuously assess arterial pressure during infusion.
  • Cardiac function: evaluate heart rhythm and contractility before and during use.
  • Extravasation risk: administer through a central line when possible.
  • Dose titration: adjust infusion rate to achieve target hemodynamics.
  • Contraindications: avoid in patients with known hypersensitivity to catecholamines.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Noradrenalin may interact with several drug classes, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Beta‑blockers: may blunt the inotropic response and precipitate severe hypotension.
  • MAO inhibitors: increase risk of hypertensive crisis.
  • Tricyclic antidepressants: potentiate vasoconstrictive effects.

Moderate Interactions (Monitor Closely)

  • Vasodilators (e.g., nitroglycerin): may require higher noradrenaline doses.
  • Calcium channel blockers: can affect vascular tone and heart rate.
  • Diuretics: may exacerbate electrolyte shifts influencing cardiovascular response.

Frequently Asked Questions

Noradrenalin Aguettant is indicated for the rapid correction of severe hypotension, septic shock, cardiac arrest, and post‑operative hypotension. It is used in critical care settings where immediate vasoconstriction and modest cardiac stimulation are required to maintain adequate organ perfusion.

Noradrenaline tartrate acts as an agonist at α1‑adrenergic receptors, causing strong vasoconstriction that raises systemic vascular resistance. It also stimulates β1‑adrenergic receptors in the heart, providing a modest increase in heart rate and contractility, together supporting blood pressure and cardiac output during shock.

The dosage of Noradrenalin Aguettant is individualized by the prescribing clinician based on the patient’s hemodynamic status, target blood pressure, and response to therapy. Dosing is typically expressed as a continuous intravenous infusion that is titrated to achieve the desired circulatory effect.

Safety data for noradrenaline tartrate in pregnancy and lactation are limited. The drug should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and it is prescribed under close medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and any required import documentation.

Noradrenalin Aguettant is a first‑line vasopressor due to its potent α1‑mediated vasoconstriction and modest β1 activity, offering a balanced increase in blood pressure and cardiac output. Compared with agents such as dopamine or phenylephrine, noradrenaline provides more predictable hemodynamic control with fewer tachyarrhythmic effects.

The product should be stored at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use to maintain stability and potency.

Noradrenalin Aguettant is supplied as an intravenous solution and is administered via continuous infusion through a central or peripheral venous line. The infusion rate is adjusted by the clinician to reach the target blood pressure while monitoring the patient’s response.

Serious risks include severe hypertension, cardiac arrhythmias, myocardial ischemia, tissue necrosis from extravasation, and pulmonary edema. Continuous hemodynamic monitoring and prompt management of any adverse events are essential during therapy.

Patients with known hypersensitivity to noradrenaline or any component of the formulation should not receive the product. Caution is also advised in individuals with severe peripheral vascular disease, uncontrolled tachyarrhythmias, or those receiving MAO inhibitors, unless the benefits clearly outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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