Product image of Noradrenalin Aguettant (Noradrenaline Tartrate) supplied by GNH India

Noradrenalin Aguettant

Active Ingredient:
Noradrenaline Tartrate
Origin:
EU

Noradrenalin Aguettant (Noradrenaline Tartrate)

Noradrenaline Tartrate, the active ingredient in Noradrenalin Aguettant, is a sympathomimetic (catecholamine) presented as an injection solution for intravenous use. It is employed to raise blood pressure in acute hypotension, septic shock, cardiac arrest and other states of circulatory failure.

GNH India supplies Noradrenalin Aguettant as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Laboratoire Aguettant

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Indications & Clinical Uses

  • Noradrenalin Aguettant acts on the sympathetic cardiovascular pathway to restore hemodynamic stability in critical care settings.
  • Acute hypotension: rapidly increases vascular tone and systemic blood pressure.
  • Septic shock: supports perfusion when endogenous catecholamine response is insufficient.
  • Cardiac arrest: provides immediate vasoconstriction and cardiac output support during resuscitation.
  • Other circulatory failure: stabilises patients with severe distributive or hypovolaemic shock.

How It Works

  • Noradrenaline Tartrate binds to alpha‑1 adrenergic receptors on vascular smooth muscle, causing potent vasoconstriction, and stimulates beta‑1 receptors in the myocardium, enhancing contractility and heart rate. The combined effect raises systemic vascular resistance and cardiac output, thereby improving arterial pressure and organ perfusion in shock states.

Side Effects

Adverse reactions may occur with intravenous catecholamine therapy.

Common Side Effects

  • Tachycardia: increased heart rate due to beta‑1 stimulation.
  • Headache: result of rapid blood pressure elevation.
  • Nausea or vomiting: gastrointestinal irritation.
  • Peripheral vasoconstriction causing cold extremities.

Serious or Rare Side Effects

  • Severe hypertension: excessive rise in arterial pressure.
  • Cardiac arrhythmias: including ventricular tachycardia.
  • Myocardial ischemia or infarction: due to increased oxygen demand.
  • Extravasation injury: tissue necrosis at the infusion site.
  • Limb ischemia: prolonged vasoconstriction compromising blood flow.

Precautions & Warnings

  • Noradrenalin Aguettant requires careful monitoring in critical care environments.
  • Monitor blood pressure continuously: adjust infusion to maintain target MAP.
  • Observe cardiac rhythm: watch for arrhythmias during titration.
  • Avoid rapid bolus administration: use controlled infusion to prevent spikes.
  • Use caution in patients with coronary artery disease: risk of myocardial ischemia.
  • Prevent extravasation: ensure secure intravenous access and inspect site regularly.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Noradrenalin Aguettant can interact with several drug classes, altering hemodynamic response.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis.
  • Ergot alkaloids: potentiation of vasoconstriction leading to severe ischemia.
  • Beta‑blockers: may blunt desired cardiac output increase.

Moderate Interactions (Monitor Closely)

  • Vasodilators (e.g., nitroglycerin): may require higher norepinephrine doses.
  • General anesthetics (e.g., propofol): can enhance hypotensive effects.
  • Calcium channel blockers: may affect vascular tone and require dose adjustment.
  • ACE inhibitors or diuretics: may influence fluid balance and blood pressure response.

Frequently Asked Questions

Noradrenalin Aguettant is an intravenous formulation of noradrenaline tartrate used in emergency and intensive‑care settings to raise systemic blood pressure. It is indicated for acute hypotension, septic shock, cardiac arrest and other severe circulatory failures where rapid hemodynamic support is required.

Noradrenaline Tartrate acts as an agonist at alpha‑1 adrenergic receptors, causing strong vasoconstriction, and at beta‑1 receptors in the heart, increasing contractility and heart rate. This dual action elevates systemic vascular resistance and cardiac output, helping to restore adequate perfusion pressure in shock.

The dose is individualized by the treating physician. In practice, a continuous intravenous infusion is started at a low rate and titrated to achieve the desired mean arterial pressure, with adjustments based on the patient’s response, underlying condition and concurrent therapies.

Safety data are limited and the product is classified as pregnancy category unknown. It should be used only when the potential benefit to the mother outweighs any possible risk to the fetus. Breastfeeding considerations are similar; use is generally avoided unless essential.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After verification of trade or institutional credentials, the sales team will provide pricing, availability, shipping details (including cold‑chain if needed) and any required import documentation.

Noradrenalin is the first‑line vasopressor for most shock states because of its balanced alpha‑ and beta‑adrenergic activity. Compared with dopamine, it produces less tachyarrhythmia, and versus phenylephrine it also supports cardiac output through beta‑1 stimulation, making it preferable when both pressure and flow are needed.

The product must be stored refrigerated at 2‑8 °C, protected from light, and must never be frozen or shaken. Prior to use, inspect the vial for particulate matter and ensure the solution is at room temperature before intravenous administration.

Noradrenalin Aguettant is given by intravenous infusion, typically through a central or large peripheral line. A trained healthcare professional prepares the solution, connects it to an infusion pump, and titrates the rate while continuously monitoring blood pressure and cardiac rhythm.

Serious risks include severe hypertension, life‑threatening cardiac arrhythmias, myocardial ischemia or infarction, and extravasation injury that can lead to tissue necrosis. Prompt recognition and immediate adjustment of the infusion rate are essential to mitigate these complications.

Contraindications include known hypersensitivity to noradrenaline or any excipients, patients with uncorrected tachyarrhythmias, severe peripheral vascular disease, and those with pheochromocytoma where catecholamine release may be exacerbated.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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