Product image of Noradrenalin Fresenius Kabi (Noradrenaline Tartrate) supplied by GNH India

Noradrenalin Fresenius Kabi

Active Ingredient:
Noradrenaline Tartrate
Origin:
EU

Noradrenalin Fresenius Kabi (Noradrenaline Tartrate)

Noradrenaline, the active ingredient in Noradrenalin Fresenius Kabi, is a vasopressor presented as a solution for injection for intravenous use. It treats acute hypotension, septic shock and cardiac arrest in critically ill patients.

GNH India supplies Noradrenalin Fresenius Kabi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Fresenius Kabi Ab

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Indications & Clinical Uses

  • Noradrenalin is a vasopressor used in critical care to restore blood pressure and support circulation.
  • Acute hypotension: raises systemic vascular resistance to improve blood pressure.
  • Septic shock: counteracts profound vasodilation to maintain organ perfusion.
  • Cardiac arrest: provides immediate alpha‑adrenergic stimulation to support coronary and cerebral blood flow.

How It Works

  • Noradrenaline acts as a direct agonist at alpha‑1 and beta‑1 adrenergic receptors on vascular smooth muscle and cardiac myocytes. Stimulation of alpha‑1 receptors produces potent vasoconstriction, increasing systemic vascular resistance, while beta‑1 activation enhances myocardial contractility and heart rate, together raising arterial pressure and cardiac output in acute circulatory failure.

Side Effects

Common Side Effects

  • Tachycardia: increased heart rate due to beta‑1 stimulation.
  • Hypertension: excessive rise in blood pressure from strong vasoconstriction.
  • Arrhythmia: irregular heart rhythms, especially in patients with underlying cardiac disease.
  • Headache: secondary to rapid blood pressure changes.
  • Nausea: gastrointestinal discomfort during infusion.
  • Peripheral ischemia: reduced blood flow to extremities at high doses.

Serious or Rare Side Effects

  • Myocardial ischemia: reduced coronary perfusion leading to chest pain or infarction.
  • Severe arrhythmias: life‑threatening ventricular tachycardia or fibrillation.
  • Tissue necrosis: extravasation causing local tissue damage.
  • Pulmonary edema: fluid accumulation in lungs due to increased afterload.
  • Cardiac arrest: paradoxical event if dosing is inappropriate.
  • Severe hypertension: risk of stroke or intracranial hemorrhage.

Precautions & Warnings

  • Noradrenalin requires careful monitoring and dose titration in critical care settings.
  • Dose titration: adjust infusion rate to achieve target mean arterial pressure.
  • Cardiovascular monitoring: continuous ECG and invasive blood pressure measurement are essential.
  • Extravasation risk: inspect IV site frequently for signs of infiltration.
  • Contraindications: avoid in patients with known hypersensitivity to noradrenaline.
  • Pregnancy and lactation: use only if benefits outweigh potential risks, as safety data are limited.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Noradrenalin may interact with several drug classes, requiring vigilance.

Major Interactions (Avoid)

  • Beta‑blockers: may blunt the pressor response, reducing efficacy.
  • MAO inhibitors: increase risk of hypertensive crisis.
  • Tricyclic antidepressants: additive vasoconstrictive effects.
  • Vasodilators (e.g., nitroglycerin): may diminish pressor action.

Moderate Interactions (Monitor Closely)

  • Calcium channel blockers: may enhance hypotensive effects if noradrenalin dose is reduced.
  • Diuretics: alter intravascular volume, affecting response.
  • ACE inhibitors: can potentiate hypotension when combined with low noradrenalin doses.

Frequently Asked Questions

Noradrenalin Fresenius Kabi is a vasopressor indicated for the rapid restoration of blood pressure in acute hypotension, septic shock, and cardiac arrest. It is administered intravenously in critical care environments to support circulatory function and maintain organ perfusion.

Noradrenaline acts as a direct agonist at alpha‑1 and beta‑1 adrenergic receptors. Alpha‑1 activation causes vasoconstriction, raising systemic vascular resistance, while beta‑1 activation increases heart rate and contractility, together elevating arterial pressure and cardiac output.

The dose of Noradrenalin Fresenius Kabi is individualized and set by the prescribing clinician based on the patient’s hemodynamic status, target blood pressure, and response to therapy. Dosage adjustments are made during continuous infusion under close monitoring.

Safety data for noradrenaline in pregnancy and lactation are limited. It should only be used when the potential benefits to the mother outweigh any possible risks to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where needed), and import documentation.

Noradrenaline is often preferred over agents such as dopamine or phenylephrine because it provides balanced alpha‑ and beta‑adrenergic stimulation, leading to effective blood pressure support with less tachyarrhythmia risk. Choice of vasopressor depends on the clinical scenario and physician judgment.

The product must be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Before use, allow the solution to reach room temperature if required, and inspect for particulate matter or discoloration.

Noradrenalin is given as an intravenous infusion, typically via a central venous catheter. The infusion rate is titrated to achieve the desired mean arterial pressure, with continuous hemodynamic monitoring to adjust dosing as needed.

Serious risks include myocardial ischemia, severe arrhythmias, tissue necrosis from extravasation, and hypertensive emergencies that can lead to stroke or intracranial hemorrhage. Prompt recognition and management of these events are essential.

Noradrenalin should be avoided in patients with known hypersensitivity to the drug, those with uncontrolled hypertension where further vasoconstriction is dangerous, and in situations where alternative pressors are more appropriate based on the clinical picture.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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