Product image of Noradrenalin Hameln (Noradrenaline Tartrate) supplied by GNH India

Noradrenalin Hameln

Active Ingredient:
Noradrenaline Tartrate
Origin:
EU

Noradrenalin Hameln (Noradrenaline Tartrate)

Noradrenaline tartrate, the active ingredient in Noradrenalin Hameln, is a sympathomimetic (catecholamine) presented as an injectable solution for intravenous use. It is employed to raise blood pressure in acute hypotensive states such as septic shock, cardiac arrest, and other emergency situations. GNH India supplies Noradrenalin Hameln as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Hameln Pharma Gmbh

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Indications & Clinical Uses

Noradrenalin Hameln is a vasopressor used in critical care to counteract severe drops in blood pressure.

  • Hypotension: restores adequate arterial pressure during acute low‑blood‑pressure episodes.
  • Septic shock: improves systemic vascular resistance and organ perfusion in infection‑related circulatory failure.
  • Cardiac arrest: supports circulation during resuscitation until spontaneous heartbeat returns.

How It Works

  • Noradrenaline tartrate acts as a direct agonist at alpha‑1 and beta‑1 adrenergic receptors. Stimulation of alpha‑1 receptors produces peripheral vasoconstriction, raising systemic vascular resistance, while beta‑1 activation increases myocardial contractility and heart rate, together enhancing cardiac output and arterial pressure in acute hypotensive states.

Side Effects

Adverse reactions may vary with dose, infusion rate, and patient condition.

Common Side Effects

  • Tachycardia: rapid heart rate due to beta‑1 stimulation.
  • Hypertension: excessive rise in blood pressure from alpha‑1 vasoconstriction.
  • Arrhythmia: irregular heart rhythms, especially in vulnerable patients.
  • Headache: transient cranial discomfort.
  • Nausea: mild gastrointestinal upset.
  • Peripheral ischemia: reduced blood flow to extremities.

Serious or Rare Side Effects

  • Myocardial ischemia: reduced heart muscle oxygenation.
  • Severe arrhythmias: life‑threatening rhythm disturbances.
  • Tissue necrosis at injection site: due to intense vasoconstriction.
  • Pulmonary edema: fluid accumulation in lungs.
  • Paradoxical cardiac arrest: rare cessation of heart activity.

Precautions & Warnings

Use of Noradrenalin Hameln requires careful monitoring and specific safety measures.

  • Monitor blood pressure: adjust infusion to maintain target MAP.
  • Assess cardiac function: avoid in uncontrolled tachyarrhythmias.
  • Use caution in myocardial ischemia: risk of worsening oxygen demand.
  • Avoid rapid bolus administration: give controlled infusion to prevent spikes.
  • Contraindicated in pheochromocytoma: may trigger hypertensive crisis.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Noradrenalin Hameln can interact with several drug classes, influencing cardiovascular response.

Major Interactions (Avoid)

  • MAO inhibitors: may precipitate hypertensive crisis.
  • Tricyclic antidepressants: additive sympathomimetic effect.
  • Beta‑blockers: can blunt intended increase in cardiac output.

Moderate Interactions (Monitor Closely)

  • Calcium channel blockers: may enhance vasoconstriction.
  • Diuretics: can potentiate reversal of hypotension.
  • Vasodilators: may require dose adjustment of noradrenaline.

Frequently Asked Questions

Noradrenalin Hameln is an intravenous vasopressor used in emergency and critical‑care settings to raise blood pressure in acute hypotension, septic shock, and during cardiac arrest when rapid circulatory support is required.

The drug directly stimulates alpha‑1 receptors causing peripheral vasoconstriction and beta‑1 receptors increasing heart contractility and rate. This combined action raises systemic vascular resistance and cardiac output, helping restore adequate arterial pressure.

The dosage is individualized by the treating physician based on the patient’s hemodynamic status, target blood pressure, and response to therapy. Clinicians calculate the infusion rate and adjust it continuously during treatment.

Safety data in pregnancy and lactation are limited. The product should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Noradrenaline is the first‑line vasopressor for most forms of distributive shock because of its balanced alpha‑1 and beta‑1 activity. Alternatives such as dopamine or phenylephrine have different receptor profiles, which may make them less suitable for certain patient populations.

The product must be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use to maintain stability.

It is supplied as an injectable solution for intravenous infusion. The medication is typically diluted in a compatible carrier fluid and administered via a controlled infusion pump, allowing precise titration to the desired blood‑pressure target.

Serious risks include myocardial ischemia, severe arrhythmias, tissue necrosis at the infusion site, and paradoxical cardiac arrest. Continuous hemodynamic monitoring and careful dose titration are essential to mitigate these hazards.

Patients with known hypersensitivity to noradrenaline or any excipients, those with pheochromocytoma, or individuals with uncontrolled tachyarrhythmias should not receive this medication unless the benefits clearly outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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