Product image of Noradrenalin Kabi (Noradrenaline Tartrate) supplied by GNH India

Noradrenalin Kabi

Active Ingredient:
Noradrenaline Tartrate
Origin:
EU

Noradrenalin Kabi (Noradrenaline Tartrate)

Norepinephrine, the active ingredient in Noradrenalin Kabi, is a sympathomimetic presented as an injection for intravenous use. It is employed to raise blood pressure in patients experiencing severe hypotension, such as septic shock, cardiac arrest, or anaphylactic reactions.\n\nGNH India supplies Noradrenalin Kabi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Fresenius Kabi Deutschland Gmbh

1
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Indications & Clinical Uses

  • Noradrenalin Kabi acts on the adrenergic system to restore vascular tone and cardiac output in critical care settings.\n\n- Hypotension: rapidly increases arterial pressure in patients with acute low blood pressure.\n- Septic shock: improves systemic vascular resistance to counteract distributive shock.\n- Cardiac arrest: supports coronary perfusion during resuscitation efforts.\n- Anaphylactic shock: counteracts severe vasodilation and maintains circulatory stability.

How It Works

  • Norepinephrine binds directly to alpha‑1 adrenergic receptors on vascular smooth muscle, causing potent vasoconstriction and raising systemic vascular resistance. It also stimulates beta‑1 receptors in the heart, modestly increasing heart rate and contractility, which together elevate mean arterial pressure and improve organ perfusion in shock states.

Side Effects

  • Adverse reactions may vary with dose, infusion rate, and patient condition.\n\nCommon Side Effects:\n- Tachycardia: increased heart rate due to beta‑1 stimulation.\n- Headache: result of rapid blood pressure changes.\n- Anxiety or restlessness: central nervous system activation.\n- Peripheral ischemia: reduced blood flow to extremities.\n- Nausea or vomiting: gastrointestinal upset.\n- Arrhythmias: ectopic beats or rhythm disturbances.\n\nSerious or Rare Side Effects:\n- Severe hypertension: excessive rise in blood pressure risking vascular injury.\n- Myocardial ischemia: reduced coronary perfusion leading to chest pain.\n- Tissue necrosis at infusion site: extravasation causing local damage.\n- Life‑threatening arrhythmias: ventricular tachycardia or fibrillation.\n- Pulmonary edema: fluid accumulation in lungs due to cardiac overload.\n- Profound bradycardia: paradoxical slowing of heart rate.

Precautions & Warnings

  • Use Noradrenalin Kabi only under continuous hemodynamic monitoring in an intensive care setting.\n\n- Cardiovascular disease: monitor for ischemia, arrhythmias, and excessive hypertension.\n- Peripheral vascular disease: avoid high infusion pressures to reduce risk of tissue necrosis.\n- Sepsis: titrate carefully to balance perfusion and vasoconstriction.\n- Concomitant vasopressors: adjust doses to prevent synergistic vasoconstriction.\n- Pregnancy and lactation: use only if benefits outweigh potential risks, as safety data are limited.\n- Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

  • Norepinephrine may interact with several drug classes, altering its efficacy or safety profile.\n\nMajor Interactions (Avoid):\n- Monoamine oxidase inhibitors: risk of hypertensive crisis.\n- Other potent vasoconstrictors (e.g., phenylephrine): may cause severe hypertension.\n- Beta‑adrenergic antagonists: can blunt desired cardiac effects.\n\nModerate Interactions (Monitor Closely):\n- ACE inhibitors or ARBs: additive hypotensive effects if norepinephrine is weaned.\n- Diuretics: may influence intravascular volume and response.\n- Calcium channel blockers: potential for altered vascular tone.\n- Anesthetic agents: may modify hemodynamic response during surgery.

Frequently Asked Questions

Noradrenalin Kabi is an intravenous vasopressor used in emergency and intensive‑care settings to raise blood pressure in patients with severe hypotension, including septic shock, anaphylactic shock, and cardiac arrest.

Norepinephrine activates alpha‑1 adrenergic receptors causing vasoconstriction, which increases systemic vascular resistance, and stimulates beta‑1 receptors in the heart to modestly raise heart rate and contractility, together improving arterial pressure and organ perfusion.

The dose of Noradrenalin Kabi is individualized by the treating physician based on the patient’s hemodynamic status, target blood pressure, and response to therapy. Specific dosing regimens are not provided here.

Safety data for norepinephrine in pregnancy and lactation are limited. It should be used only if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by the prescriber.

To order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where needed) and import documentation.

Norepinephrine is often preferred over agents like dopamine or phenylephrine because it provides strong alpha‑mediated vasoconstriction with modest beta‑1 activity, offering balanced blood pressure support with a lower risk of tachyarrhythmias compared with dopamine.

Noradrenalin Kabi must be stored at 2‑8 °C, protected from light, and should not be frozen or shaken. Keep the product in its original packaging until ready for use.

The medication is supplied as a sterile injection for intravenous infusion. It is typically administered via a calibrated infusion pump, with continuous blood pressure monitoring to titrate the rate to the desired hemodynamic response.

Serious risks include severe hypertension, myocardial ischemia, tissue necrosis at the infusion site due to extravasation, life‑threatening arrhythmias, and pulmonary edema. Immediate medical attention is required if any of these events occur.

Patients with known hypersensitivity to norepinephrine or any excipients, those with uncontrolled hypertension, or individuals in whom excessive vasoconstriction could cause limb ischemia should not receive the drug. Contraindications are determined by the prescribing clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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