Product image of Noradrenalin Laboratoire Aguettant (Noradrenaline Tartrate) supplied by GNH India

Noradrenalin Laboratoire Aguettant

Active Ingredient:
Noradrenaline Tartrate
Origin:
EU

Noradrenalin Laboratoire Aguettant (Noradrenaline Tartrate)

Noradrenaline tartrate, the active ingredient in Noradrenalin Laboratoire Aguettant, is an adrenergic agonist presented as an injectable solution for intravenous use. It is employed to raise blood pressure and improve cardiac output in patients with severe hypotension, septic shock or cardiogenic shock.

GNH India supplies Noradrenalin Laboratoire Aguettant as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Laboratoire Aguettant

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Indications & Clinical Uses

Noradrenalin Laboratoire Aguettant acts as a potent vasopressor in critical‑care settings, targeting circulatory failure and shock states.

  • Hypotension: restores arterial pressure to maintain organ perfusion.
  • Septic shock: counteracts vasodilatory failure to improve systemic vascular resistance.
  • Cardiogenic shock: enhances cardiac output and coronary perfusion by stimulating beta‑1 receptors.

How It Works

  • Noradrenaline tartrate binds directly to alpha‑1 and beta‑1 adrenergic receptors on vascular smooth muscle and cardiac myocytes. Alpha‑1 activation produces peripheral vasoconstriction, raising systemic vascular resistance, while beta‑1 stimulation increases heart rate and contractility, together elevating arterial pressure and cardiac output in acute shock states.

Side Effects

Noradrenalin may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Tachycardia: rapid heart rate due to beta‑1 stimulation.
  • Hypertension: excessive rise in blood pressure.
  • Headache: often related to vascular changes.
  • Nausea: gastrointestinal discomfort.

Serious or Rare Side Effects

  • Myocardial ischemia: reduced coronary blood flow.
  • Severe hypertension: risk of vascular injury.
  • Life‑threatening arrhythmias: abnormal heart rhythms.
  • Tissue necrosis at infusion site: extravasation injury.

Precautions & Warnings

When using Noradrenalin, clinicians should observe several safety measures.

  • Blood pressure monitoring: adjust infusion to avoid overshoot.
  • Cardiac rhythm surveillance: detect arrhythmias early.
  • Coronary artery disease caution: limit dose to prevent ischemia.
  • Hyperthyroidism awareness: heightened sensitivity to catecholamines.
  • Avoid rapid bolus: administer as controlled infusion.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Noradrenalin can interact with other agents that affect cardiovascular tone.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis.
  • Tricyclic antidepressants: additive pressor effect.
  • Beta‑blockers: may blunt therapeutic response.

Moderate Interactions (Monitor Closely)

  • Diuretics: may potentiate hypotensive episodes.
  • Calcium channel blockers: can alter vascular response.
  • ACE inhibitors: may affect blood pressure stability.

Frequently Asked Questions

Noradrenalin Laboratoire Aguettant is indicated for the treatment of severe hypotension, septic shock, and cardiogenic shock. In these critical situations it helps raise blood pressure and improve cardiac output by stimulating adrenergic receptors.

Noradrenaline tartrate acts as a direct agonist at alpha‑1 and beta‑1 adrenergic receptors. Alpha‑1 activation causes peripheral vasoconstriction, while beta‑1 activation increases heart rate and contractility, together supporting blood pressure and cardiac output during shock.

The dose of Noradrenalin Laboratoire Aguettant is individualized by the prescribing clinician based on the patient’s hemodynamic status, response to therapy, and institutional protocols. The infusion rate is titrated to achieve target blood pressure.

The safety of noradrenaline in pregnancy and lactation has not been established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if required) and import documentation.

Noradrenalin is the first‑line vasopressor for most shock states because of its balanced alpha‑1 and beta‑1 activity. Compared with agents such as dopamine or phenylephrine, it provides more predictable increases in blood pressure with fewer arrhythmic risks, making it the preferred choice in many guidelines.

Noradrenalin Laboratoire Aguettant should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the solution from moisture and direct sunlight. Do not freeze or shake the vial before use.

The drug is supplied as an injectable solution for intravenous infusion. It is typically administered through a calibrated infusion pump, allowing precise titration of the dose to achieve the desired hemodynamic effect.

Serious risks include myocardial ischemia, severe hypertension, life‑threatening arrhythmias, and tissue necrosis if the drug extravasates from the vein. Continuous monitoring of cardiovascular parameters is essential to detect and manage these complications promptly.

Patients with known hypersensitivity to noradrenaline or any excipients in the formulation should not receive the product. Caution is also advised in individuals with severe coronary artery disease, uncontrolled tachyarrhythmias, or those receiving MAO inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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