Product image of Noradrenalin Macure (Norepinephrine) supplied by GNH India

Noradrenalin Macure

Active Ingredient:
Norepinephrine
Origin:
EU

Noradrenalin Macure (Norepinephrine)

Norepinephrine, the active ingredient in Noradrenalin Macure, is a sympathomimetic (vasopressor) presented as an intravenous solution for intravenous use. It is employed to raise blood pressure and support cardiac output in acute hypotensive states such as septic shock, cardiac arrest, and postoperative hypotension.

GNH India supplies Noradrenalin Macure as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Macure Pharma Aps

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Indications & Clinical Uses

Norepinephrine is used in the management of acute cardiovascular conditions where rapid restoration of vascular tone or cardiac output is required.

  • Hypotension: raises systemic blood pressure in patients with low arterial pressure.
  • Septic shock: improves hemodynamic stability during severe infection‑related vasodilation.
  • Cardiac arrest: provides pressor support to maintain perfusion during resuscitation.
  • Postoperative hypotension: corrects blood pressure drops following surgery.

How It Works

  • Norepinephrine acts as a direct agonist at alpha‑1 adrenergic receptors, causing peripheral vasoconstriction, and also stimulates beta‑1 receptors in the heart, increasing contractility and heart rate. The combined alpha and beta activity elevates systemic vascular resistance and cardiac output, thereby improving arterial pressure in acute circulatory failure.

Side Effects

Norepinephrine may produce a range of adverse reactions that vary with dose and infusion rate.

Common Side Effects

  • Tachycardia: rapid heart rate due to beta‑1 stimulation.
  • Headache: result of increased vascular tone.
  • Anxiety or restlessness: central adrenergic effects.
  • Nausea or vomiting: gastrointestinal irritation.
  • Peripheral vasoconstriction causing cold extremities.
  • Arrhythmias: ectopic beats or atrial fibrillation.

Serious or Rare Side Effects

  • Severe hypertension: excessive rise in blood pressure.
  • Cardiac ischemia: reduced coronary perfusion from high afterload.
  • Peripheral tissue necrosis: extravasation at infusion site.
  • Pulmonary edema: fluid accumulation due to increased afterload.
  • Reflex bradycardia: vagal response to abrupt pressure rise.
  • Life‑threatening arrhythmias: ventricular tachycardia or fibrillation.

Precautions & Warnings

Norepinephrine requires careful monitoring and specific safety measures before and during administration.

  • Blood pressure monitoring: continuous invasive measurement is essential.
  • Cardiac disease caution: use cautiously in patients with coronary artery disease or recent myocardial infarction.
  • Infusion rate control: avoid rapid bolus; titrate slowly to target pressure.
  • Volume status assessment: ensure adequate intravascular volume before starting.
  • Contraindications: do not use in patients with pheochromocytoma or uncorrected hypovolemia.
  • Store at controlled room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Norepinephrine can interact with other agents that affect the adrenergic system or blood pressure.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis due to synergistic catecholamine effects.
  • Tricyclic antidepressants: additive pressor response may cause severe hypertension.
  • Beta‑blockers: may blunt the desired increase in cardiac output and heart rate.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: may enhance hypotensive response when norepinephrine is weaned.
  • Calcium channel blockers: possible additive vasoconstriction leading to excessive blood pressure.
  • Diuretics: altered intravascular volume can affect drug efficacy and safety.

Frequently Asked Questions

Noradrenalin Macure, containing norepinephrine, is indicated for acute hypotension, septic shock, cardiac arrest, and postoperative hypotension. It is administered intravenously to rapidly increase blood pressure and support cardiac output in emergency or critical care settings.

Norepinephrine acts as a direct agonist at alpha‑1 adrenergic receptors, causing peripheral vasoconstriction, and stimulates beta‑1 receptors in the heart, enhancing contractility and heart rate. This dual action raises systemic vascular resistance and cardiac output, improving arterial pressure.

The specific dose and infusion rate of Noradrenalin Macure are determined by the prescribing clinician based on the patient’s hemodynamic status, target blood pressure, and response to therapy. Dosing is individualized and adjusted under continuous monitoring.

The safety of norepinephrine in pregnancy or lactation has not been definitively established. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by the treating physician.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Norepinephrine is generally preferred as a first‑line vasopressor because of its potent alpha‑1 mediated vasoconstriction combined with modest beta‑1 activity, offering balanced blood pressure support. Alternatives such as phenylephrine lack beta‑1 effects, while epinephrine has stronger beta activity, which may increase heart rate more markedly.

Store Noradrenalin Macure at controlled room temperature, below 25 °C, in its original packaging. Protect the solution from light and moisture, and avoid freezing. Ensure the vial is kept upright and inspected for particulate matter before use.

Noradrenalin Macure is given as an intravenous infusion. It is typically diluted in a compatible carrier solution and administered via a calibrated infusion pump, allowing precise titration to achieve the desired blood pressure target while monitoring the patient continuously.

Serious risks include severe hypertension, cardiac ischemia, arrhythmias, peripheral tissue necrosis from extravasation, and reflex bradycardia. Immediate recognition and management of these events are essential, and infusion should be stopped if life‑threatening complications arise.

Contraindications include patients with pheochromocytoma, uncorrected hypovolemia, or known hypersensitivity to norepinephrine. Caution is advised in individuals with severe coronary artery disease, uncontrolled arrhythmias, or peripheral vascular disease, where the drug’s vasoconstrictive effects may be harmful.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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