Product image of Noradrenalin (Norepinephrin) Aguettant (Noradrenaline Tartrate) supplied by GNH India

Noradrenalin (Norepinephrin) Aguettant

Active Ingredient:
Noradrenaline Tartrate
Origin:
EU

Noradrenalin (Norepinephrin) Aguettant (Noradrenaline Tartrate)

Noradrenaline Tartrate, the active ingredient in Noradrenalin (Norepinephrin) Aguettant, is a sympathomimetic (vasopressor) presented as an injectable solution for intravenous use. It treats acute hypotension, septic shock and cardiac arrest in hospitalized patients.

GNH India supplies Noradrenalin (Norepinephrin) Aguettant as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Laboratoire Aguettant

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Indications & Clinical Uses

  • Noradrenalin (Norepinephrin) Aguettant is a vasopressor used in critical care settings to support blood pressure.
  • Acute hypotension: restores systemic vascular resistance and raises arterial pressure.
  • Septic shock: improves perfusion by counteracting vasodilatory shock.
  • Cardiac arrest: provides pressor support during resuscitation.

How It Works

  • Noradrenalin (Norepinephrin) Aguettant acts primarily as an alpha‑adrenergic receptor agonist, inducing potent vasoconstriction that increases systemic vascular resistance and elevates arterial blood pressure. It may also exert modest beta‑1 adrenergic activity, contributing to increased cardiac output. The combined effect rapidly restores hemodynamic stability in patients with severe hypotension.

Side Effects

Common Side Effects

  • Headache: mild to moderate discomfort.
  • Tachycardia: increased heart rate.
  • Hypertension: elevated blood pressure.
  • Nausea: occasional gastrointestinal upset.
  • Anxiety: transient nervousness.
  • Arrhythmia: irregular heart rhythm.

Serious or Rare Side Effects

  • Myocardial ischemia: reduced heart muscle blood flow.
  • Severe hypertension: dangerously high blood pressure.
  • Tissue necrosis at infusion site: local tissue death.
  • Life‑threatening arrhythmias: ventricular tachycardia or fibrillation.
  • Peripheral ischemia: reduced blood flow to extremities.

Precautions & Warnings

  • Noradrenalin (Norepinephrin) Aguettant requires careful monitoring in critical care environments.
  • Monitor blood pressure: adjust infusion to avoid excessive hypertension.
  • Cardiac monitoring: watch for arrhythmias and ischemic changes.
  • Coronary disease caution: risk of myocardial ischemia in patients with known CAD.
  • Uncontrolled hypertension: avoid use unless benefits outweigh risks.
  • Pregnancy safety: limited data; use only if essential.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Noradrenalin (Norepinephrin) Aguettant may interact with several drug classes.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis.
  • Tricyclic antidepressants: additive pressor effects.
  • Beta‑blockers: may blunt tachycardic response.

Moderate Interactions (Monitor Closely)

  • Vasodilators (e.g., nitroglycerin): may require higher pressor doses.
  • Calcium channel blockers: can affect vascular tone.
  • Diuretics: influence intravascular volume and response.

Frequently Asked Questions

Noradrenalin (Norepinephrin) Aguettant is used as a vasopressor in acute care to raise blood pressure in conditions such as acute hypotension, septic shock, and cardiac arrest. It is administered intravenously under strict medical supervision to stabilize hemodynamics.

Noradrenaline acts as an alpha‑adrenergic receptor agonist, causing vasoconstriction and increasing systemic vascular resistance, which elevates arterial pressure. It may also provide modest beta‑1 stimulation, supporting cardiac output and helping restore circulatory stability.

The dosage is individualized; a qualified prescriber determines the infusion rate and concentration based on the patient’s hemodynamic status, target blood pressure, and clinical response. No fixed regimen is provided here.

Safety data are limited; the drug is classified as pregnancy category unknown. It should be used only if the potential benefit justifies the potential risk to the fetus, and breastfeeding decisions should be made with a healthcare professional.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and necessary import documentation.

The primary alternative is norepinephrine produced by other manufacturers; clinical efficacy is comparable as both are alpha‑adrenergic agonists. Differences may lie in formulation, concentration, packaging, and supplier services such as GMP compliance and global logistics.

The injectable solution should be stored at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the vial in its original container until use and discard any solution that appears discolored or particulate.

Noradrenalin is given intravenously, typically as a continuous infusion. The solution is added to a compatible IV fluid bag or administered via a syringe pump, with the rate adjusted to achieve the desired blood pressure target under continuous monitoring.

Serious adverse events include severe hypertension, myocardial ischemia, life‑threatening arrhythmias, and peripheral tissue necrosis at the infusion site. Prompt recognition and immediate intervention are essential to mitigate these complications.

Patients with uncontrolled hypertension, known hypersensitivity to noradrenaline or its excipients, and those in whom a rapid increase in vascular tone could be harmful (e.g., severe coronary artery disease) should avoid its use unless a clinician determines that benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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