Product image of Noradrenalin Sintetica (Noradrenaline Tartrate) supplied by GNH India

Noradrenalin Sintetica

Active Ingredient:
Noradrenaline Tartrate
Origin:
EU

Noradrenalin Sintetica (Noradrenaline Tartrate)

Norepinephrine, the active ingredient in Noradrenalin Sintetica, is a sympathomimetic vasopressor presented as a sterile solution for injection for intravenous use. It is employed in acute care to raise blood pressure and improve cardiac output in patients with hypotension, cardiac arrest, or septic shock, acting on adrenergic receptors to restore hemodynamic stability.

GNH India supplies Noradrenalin Sintetica as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, intensive care units, emergency departments and pharmacy networks worldwide, ensuring quality‑controlled product availability for critical care environments.

Manufacturer / TM Owner

Sintetica Gmbh

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Indications & Clinical Uses

Noradrenalin Sintetica (norepinephrine) is a vasopressor used in the management of severe hypotensive states.

  • Hypotension: restores arterial pressure by vasoconstriction, improving organ perfusion.
  • Cardiac arrest: supports coronary and cerebral perfusion during resuscitation efforts.
  • Septic shock: counteracts vasodilatory shock to maintain adequate blood pressure.

How It Works

  • Norepinephrine acts as a direct agonist at alpha‑1 adrenergic receptors, producing potent peripheral vasoconstriction, and at beta‑1 receptors, enhancing myocardial contractility and heart rate. This dual activity increases systemic vascular resistance and cardiac output, thereby elevating arterial blood pressure and improving tissue perfusion in critically ill patients.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Tachycardia: increased heart rate due to beta‑1 stimulation.
  • Headache: result of rapid blood pressure changes.
  • Anxiety or restlessness: central adrenergic effects.
  • Nausea: gastrointestinal upset.
  • Peripheral ischemia: reduced blood flow to extremities.

Serious or Rare Side Effects

  • Severe hypertension: excessive vasoconstriction leading to dangerously high blood pressure.
  • Myocardial ischemia: reduced coronary perfusion causing chest pain or infarction.
  • Life‑threatening arrhythmias: ventricular tachycardia or fibrillation.
  • Tissue necrosis at injection site: extravasation causing local damage.
  • Pulmonary edema: fluid accumulation due to increased afterload.

Precautions & Warnings

Use requires careful monitoring and adherence to safety measures.

  • Blood pressure monitoring: adjust infusion to maintain target MAP.
  • Cardiac monitoring: watch for arrhythmias and ischemia.
  • Dose titration: increase gradually to avoid abrupt hypertension.
  • Extravasation risk: administer through a central line when possible.
  • Contraindications: avoid in patients with known hypersensitivity or uncontrolled peripheral ischemia.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Norepinephrine may interact with other agents affecting cardiovascular tone.

Major Interactions (Avoid)

  • MAO inhibitors: can potentiate hypertensive response.
  • Tricyclic antidepressants: increase risk of severe hypertension.
  • Beta‑blockers: may blunt desired cardiac effects.

Moderate Interactions (Monitor Closely)

  • Vasodilators (e.g., nitroglycerin): may reduce efficacy of norepinephrine.
  • ACE inhibitors or ARBs: can alter blood pressure response.
  • Other vasopressors: additive effects may cause excessive vasoconstriction.

Frequently Asked Questions

Noradrenalin Sintetica is a sterile injectable solution of norepinephrine used as a vasopressor in acute care to treat severe hypotension, cardiac arrest, and septic shock, helping to raise blood pressure and support cardiac output.

Norepinephrine acts as a direct agonist at alpha‑1 adrenergic receptors, causing peripheral vasoconstriction, and at beta‑1 receptors, increasing heart contractility and rate. This combined effect raises systemic vascular resistance and cardiac output, restoring hemodynamic stability.

The dosing regimen is individualized; the prescribing clinician determines the infusion rate and titration based on the patient’s hemodynamic response and target blood pressure.

Safety data are limited; norepinephrine is classified as pregnancy category unknown, and it should be used only if the potential benefit justifies the potential risk to the fetus. Use during breastfeeding is also not well studied, so caution is advised.

Submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and necessary import documentation.

Both are vasopressors, but norepinephrine has combined alpha‑1 and beta‑1 activity, providing both vasoconstriction and increased cardiac output, whereas phenylephrine is a pure alpha‑1 agonist, leading mainly to vasoconstriction without direct cardiac stimulation.

Noradrenalin Sintetica should be stored at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use.

The solution is given by intravenous infusion, typically through a central line or a large peripheral vein, with the infusion rate adjusted to achieve the desired blood pressure target under continuous hemodynamic monitoring.

Serious adverse events include severe hypertension, myocardial ischemia, arrhythmias such as ventricular tachycardia, and tissue necrosis if extravasation occurs; patients should be closely monitored for these complications.

Contraindications include patients with known hypersensitivity to norepinephrine, uncontrolled mesenteric or peripheral vascular ischemia, and those in whom vasoconstriction could exacerbate existing conditions; use is also avoided in patients receiving MAO inhibitors without careful supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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