Product image of Noradrenalin Sintetica (Noradrenaline Tartrate) supplied by GNH India

Noradrenalin Sintetica

Active Ingredient:
Noradrenaline Tartrate
Origin:
EU

Noradrenalin Sintetica (Noradrenaline Tartrate)

Noradrenaline tartrate, the active ingredient in Noradrenalin Sintetica, is a sympathomimetic agent presented as an injectable solution for intravenous use. It is employed to raise blood pressure and improve cardiac output in acute circulatory failure such as hypotension, septic shock and cardiac arrest.
GNH India supplies Noradrenalin Sintetica as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Sintetica Gmbh

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Indications & Clinical Uses

Noradrenalin Sintetica is a vasopressor that acts on the sympathetic cardiovascular pathway to restore adequate perfusion.

  • Hypotension: raises systemic vascular resistance to increase arterial pressure.
  • Septic shock: counteracts profound vasodilation and supports organ perfusion.
  • Cardiac arrest: enhances coronary and cerebral blood flow during resuscitation efforts.

How It Works

  • Noradrenaline tartrate acts as a direct agonist at alpha‑adrenergic receptors, producing potent vasoconstriction and elevating systemic vascular resistance. It also stimulates beta‑1 receptors in the heart, increasing contractility and cardiac output, thereby improving overall hemodynamic stability in critically ill patients.

Side Effects

Adverse reactions may occur with intravenous administration of Noradrenalin Sintetica.

Common Side Effects

  • Headache: transient, often related to rapid blood pressure changes.
  • Tachycardia: increased heart rate due to beta‑1 stimulation.
  • Palpitation: awareness of heartbeats during infusion.
  • Nausea: mild gastrointestinal discomfort.
  • Peripheral ischemia: reduced blood flow to extremities.

Serious or Rare Side Effects

  • Arrhythmias: potentially life‑threatening rhythm disturbances.
  • Myocardial ischemia: chest pain or infarction from excessive vasoconstriction.
  • Severe hypertension: abrupt, dangerous rise in blood pressure.
  • Tissue necrosis: extravasation at the infusion site.
  • Pulmonary edema: fluid accumulation in lungs due to cardiac overload.

Precautions & Warnings

Noradrenalin Sintetica requires careful monitoring and specific safety measures.

  • Cardiac monitoring: continuous ECG to detect arrhythmias.
  • Blood pressure monitoring: frequent measurements to avoid overshoot hypertension.
  • Dose titration: adjust infusion rate based on hemodynamic response.
  • Extravasation risk: use central venous access when possible.
  • Contraindications: avoid in patients with uncorrected pheochromocytoma.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Noradrenalin Sintetica can interact with other agents that affect cardiovascular tone.

Major Interactions (Avoid)

  • Beta‑blockers: may blunt desired increase in cardiac output.
  • MAO inhibitors: can potentiate hypertensive response.
  • Tricyclic antidepressants: increase risk of severe hypertension.

Moderate Interactions (Monitor Closely)

  • Calcium channel blockers: additive vasodilatory effects may require dose adjustment.
  • Diuretics: may exacerbate hypovolemia, influencing response.
  • Inhaled anesthetics: can alter vascular reactivity during surgery.

Frequently Asked Questions

Noradrenalin Sintetica is indicated for the acute management of severe hypotension, septic shock, and cardiac arrest. In these critical situations it helps raise blood pressure and improve organ perfusion by stimulating vascular and cardiac receptors.

Noradrenaline tartrate acts as a direct agonist at alpha‑adrenergic receptors, causing vasoconstriction and increasing systemic vascular resistance. It also stimulates beta‑1 receptors in the heart, enhancing contractility and cardiac output, which together support blood pressure and tissue perfusion.

The dosage of Noradrenalin Sintetica is individualized and set by the prescribing clinician based on the patient’s hemodynamic status, response to therapy, and clinical guidelines. Dosing is typically administered as an intravenous infusion that is titrated to effect.

The safety of Noradrenalin Sintetica in pregnancy and lactation has not been established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Noradrenalin Sintetica is a first‑line vasopressor because of its strong alpha‑adrenergic activity combined with modest beta‑1 stimulation. Compared with agents such as dopamine or phenylephrine, it provides more predictable increases in blood pressure with less tachyarrhythmia risk, making it preferred in many critical‑care protocols.

The product should be stored at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep it in the original packaging to maintain stability until it is prepared for intravenous administration.

Noradrenalin Sintetica is supplied as an injectable solution for intravenous infusion. It is typically administered through a central venous catheter, with the infusion rate adjusted continuously based on the patient’s blood pressure and cardiac response.

Serious risks include severe hypertension, life‑threatening arrhythmias, myocardial ischemia, tissue necrosis from extravasation, and pulmonary edema. Continuous hemodynamic monitoring is essential to detect and manage these complications promptly.

Patients with known hypersensitivity to noradrenaline or its excipients, uncorrected pheochromocytoma, or those in whom severe vasoconstriction could cause harm (e.g., certain peripheral vascular diseases) should not receive this medication. Clinical judgment is required for each case.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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