Product image of Noradrenalina Aguettant (Noradrenaline Tartrate) supplied by GNH India

Noradrenalina Aguettant

Active Ingredient:
Noradrenaline Tartrate
Origin:
EU

Noradrenalina Aguettant (Noradrenaline Tartrate)

Noradrenaline tartrate, the active ingredient in Noradrenalina Aguettant, is a sympathomimetic agent presented as a sterile injectable solution for intravenous use. It is employed to raise blood pressure in acute hypotensive states such as septic shock and cardiac arrest.
GNH India supplies Noradrenalina Aguettant as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Laboratoire Aguettant

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Indications & Clinical Uses

Noradrenaline tartrate acts as a potent vasopressor influencing the sympathetic circulatory pathway.

  • Hypotension: restores adequate arterial pressure in patients with severe low blood pressure.
  • Septic shock: improves systemic vascular resistance to counteract distributive shock.
  • Cardiac arrest: supports coronary perfusion pressure during resuscitation efforts.

How It Works

  • Noradrenaline tartrate directly stimulates alpha‑adrenergic receptors on vascular smooth muscle, causing vasoconstriction and an increase in systemic vascular resistance. The resultant rise in arterial pressure enhances organ perfusion, while beta‑adrenergic activity may modestly increase cardiac output. This combined effect makes it a first‑line agent for rapid hemodynamic support in critical care.

Side Effects

Noradrenaline tartrate may be associated with a range of adverse reactions.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Tachycardia: increased heart rate due to beta‑adrenergic stimulation.
  • Nausea: occasional gastrointestinal discomfort.
  • Anxiety or restlessness: central nervous system activation.
  • Peripheral ischemia: reduced blood flow to extremities.

Serious or Rare Side Effects

  • Severe hypertension: excessive rise in blood pressure.
  • Myocardial infarction: risk of cardiac ischemia in susceptible patients.
  • Tissue necrosis at infusion site: extravasation injury.
  • Life‑threatening arrhythmias: ventricular tachycardia or fibrillation.
  • Anaphylactic reaction: rare hypersensitivity requiring immediate intervention.

Precautions & Warnings

Noradrenaline tartrate requires careful clinical monitoring and adherence to safety guidelines.

  • Cardiovascular monitoring: continuous blood pressure and heart‑rate observation during infusion.
  • Dose titration: adjust infusion rate based on hemodynamic response and target pressures.
  • Contraindications: avoid in patients with known hypersensitivity to catecholamines.
  • Drug interactions: review concomitant use of MAO inhibitors or tricyclic antidepressants.
  • Pregnancy and lactation: use only if potential benefits outweigh risks.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Noradrenaline tartrate can interact with several medication classes, influencing its efficacy and safety.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis.
  • Tricyclic antidepressants: potentiation of vasoconstrictive effects.
  • Beta‑blockers: may blunt desired cardiovascular response.
  • Ergot alkaloids: increased risk of severe vasospasm.

Moderate Interactions (Monitor Closely)

  • Vasodilators (e.g., nitroglycerin): may require higher noradrenaline doses.
  • ACE inhibitors or ARBs: additive blood‑pressure effects.
  • Diuretics: potential for volume depletion affecting response.
  • Other vasopressors: overlapping mechanisms may necessitate dose adjustments.

Frequently Asked Questions

Noradrenalina Aguettant contains noradrenaline tartrate and is used as a vasopressor to raise blood pressure in acute hypotensive conditions such as severe hypotension, septic shock, and during cardiac arrest resuscitation.

Noradrenaline tartrate acts as a direct agonist at alpha‑adrenergic receptors, causing vasoconstriction and increasing systemic vascular resistance. This elevates arterial pressure and improves organ perfusion, while modest beta‑adrenergic activity may support cardiac output.

The dosage of Noradrenalina Aguettant is individualized. The prescribing clinician determines the infusion rate and titration based on the patient’s hemodynamic status and therapeutic goals.

Safety data are limited. The product should be used in pregnancy or while breastfeeding only if the potential benefits justify any possible risk to the fetus or infant, and under close medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Noradrenaline tartrate is considered a first‑line vasopressor because of its potent alpha‑adrenergic activity and relatively predictable hemodynamic profile. Compared with agents such as dopamine or phenylephrine, it provides stronger vasoconstriction with less tachyarrhythmic risk, making it preferred in many critical‑care protocols.

The product should be stored at 2‑8 °C, protected from light, and kept in its original container. Do not freeze or shake the solution. Before use, inspect for particulate matter and ensure the vial is at the correct temperature.

Noradrenalina Aguettant is given intravenously, typically as a continuous infusion. The solution is added to a compatible infusion set and administered through a central or large‑bore peripheral line, with dosing adjusted according to real‑time blood‑pressure monitoring.

Serious risks include severe hypertension, myocardial ischemia or infarction, life‑threatening arrhythmias, tissue necrosis from extravasation, and rare anaphylactic reactions. Continuous cardiovascular monitoring is essential to detect and manage these events promptly.

Patients with known hypersensitivity to noradrenaline or other catecholamines, those with uncorrected severe peripheral vascular disease, or individuals in whom vasoconstriction could worsen tissue perfusion should not receive the drug. Clinical judgment is required for each case.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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