Product image of Noradrenalina Generis (Noradrenaline Tartrate) supplied by GNH India

Noradrenalina Generis

Active Ingredient:
Noradrenaline Tartrate
Origin:
EU

Noradrenalina Generis (Noradrenaline Tartrate)

Noradrenaline Tartrate, the active ingredient in Noradrenalina Generis, is a sympathomimetic vasopressor presented as an injectable solution for intravenous administration. It is employed in critical care to raise blood pressure and improve cardiac output in patients experiencing acute hypotension, septic shock, cardiogenic shock, or cardiac arrest. All batches meet EU pharmacopoeial standards and are manufactured under GMP conditions.

GNH India supplies Noradrenalina Generis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Eugia Pharma (Malta) Ltd

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Indications & Clinical Uses

Noradrenalina Generis, a vasopressor acting on the adrenergic system, is indicated for several acute cardiovascular emergencies.

  • Acute hypotension: restores systemic vascular resistance to maintain adequate perfusion pressure.
  • Septic shock: supports blood pressure when fluid resuscitation alone is insufficient.
  • Cardiogenic shock: enhances cardiac output by increasing contractility and heart rate.
  • Cardiac arrest: provides immediate pressor support during advanced life‑saving measures.

How It Works

  • Noradrenaline Tartrate acts as a direct agonist at alpha‑1 adrenergic receptors, producing peripheral vasoconstriction, and at beta‑1 receptors, increasing myocardial contractility and heart rate. The combined alpha and beta stimulation raises systemic vascular resistance and cardiac output, thereby improving arterial pressure in states of acute circulatory failure.

Side Effects

Noradrenalina Generis may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Headache: transient, often related to rapid blood pressure changes.
  • Tachycardia: increased heart rate due to beta‑1 stimulation.
  • Arrhythmia: premature beats or mild rhythm disturbances.
  • Hypertension: excessive rise in blood pressure if dose is too high.
  • Nausea: gastrointestinal discomfort during infusion.
  • Anxiety: feelings of nervousness or restlessness.

Serious or Rare Side Effects

  • Myocardial ischemia: reduced coronary perfusion from high afterload.
  • Severe arrhythmias: ventricular tachycardia or fibrillation.
  • Tissue necrosis: extravasation at the infusion site.
  • Pulmonary edema: fluid accumulation due to increased afterload.
  • Extreme hypertension: risk of intracranial hemorrhage.
  • Cardiac arrest: paradoxical failure despite pressor therapy.

Precautions & Warnings

Use of Noradrenalina Generis requires careful clinical monitoring and adherence to safety guidelines.

  • Cardiovascular monitoring: continuous blood pressure and heart‑rate observation is essential.
  • Titration: infusion rate should be adjusted to achieve target hemodynamics.
  • Contraindications: avoid in patients with uncorrected pheochromocytoma or severe peripheral vascular disease.
  • Drug interactions: monitor closely when combined with MAO inhibitors, tricyclic antidepressants, or ergot alkaloids.
  • Pregnancy and lactation: only if potential benefit justifies potential risk; data are limited.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Noradrenalina Generis can interact with several drug classes, requiring vigilance.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis.
  • Beta‑blockers: may blunt desired chronotropic effects.
  • Tricyclic antidepressants: additive vasoconstriction and hypertension.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: may enhance hypotensive episodes after dose reduction.
  • Diuretics: synergistic blood‑pressure lowering effect.
  • Other vasopressors: cumulative pressor effect can cause severe hypertension.
  • Anesthetic agents: altered hemodynamic response during surgery.
  • Calcium channel blockers: may affect vascular tone and heart rate.

Frequently Asked Questions

Noradrenalina Generis is an intravenous vasopressor indicated for the rapid correction of acute hypotension, septic shock, cardiogenic shock, and as a supportive pressor during cardiac arrest. It is used in intensive‑care and emergency settings to stabilize blood pressure and improve cardiac output in critically ill patients.

Noradrenaline Tartrate acts as a direct agonist at alpha‑1 adrenergic receptors, causing peripheral vasoconstriction, and at beta‑1 receptors, increasing heart‑muscle contractility and rate. This dual action raises systemic vascular resistance and cardiac output, thereby elevating arterial pressure in states of circulatory collapse.

The dose of Noradrenalina Generis is individualized and set by the treating physician. Dosing is typically expressed as micrograms per kilogram per minute and is titrated to achieve target blood‑pressure goals while monitoring for adverse effects.

Safety data for Noradrenalina Generis in pregnancy and lactation are limited. It should be used only when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by the prescriber.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and any necessary import documentation.

Noradrenaline provides both alpha‑1 mediated vasoconstriction and beta‑1 cardiac stimulation, offering a balanced pressor effect. Compared with dopamine, it has less tachyarrhythmic potential, and unlike phenylephrine, it also supports heart‑rate and contractility, making it a preferred first‑line agent in many shock protocols.

The product must be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Before use, inspect the vial for particulate matter and ensure the solution is at room temperature if required for infusion preparation.

Noradrenalina Generis is given as an intravenous infusion. The vial is typically diluted in a compatible carrier solution (e.g., 5% dextrose or normal saline) and administered via a calibrated infusion pump, allowing precise titration based on the patient’s hemodynamic response.

Serious risks include severe hypertension, myocardial ischemia, life‑threatening arrhythmias, tissue necrosis from extravasation, and pulmonary edema. Continuous cardiovascular monitoring and prompt adjustment of the infusion rate are essential to mitigate these dangers.

Patients with uncorrected pheochromocytoma, severe peripheral vascular disease, or known hypersensitivity to noradrenaline or any excipients should not receive Noradrenalina Generis. Contraindications must be confirmed by the prescribing clinician before initiation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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