Product image of Noradrenalina Labesfal (Noradrenaline Tartrate) supplied by GNH India

Noradrenalina Labesfal

Active Ingredient:
Noradrenaline Tartrate
Origin:
EU

Noradrenalina Labesfal (Noradrenaline Tartrate)

Noradrenaline tartrate, the active ingredient in Noradrenalina Labesfal, is an adrenergic agonist presented as an intravenous solution for intravenous use. It is employed to raise blood pressure in patients with hypotension, support circulation during cardiac arrest, and improve vascular tone in septic shock.
GNH India supplies Noradrenalina Labesfal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Labesfal Laboratorios Almiro, S.A.

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Indications & Clinical Uses

Noradrenalina Labesfal acts as a potent vasopressor in critical‑care settings, targeting severe circulatory failure.

  • Hypotension: restores arterial pressure by inducing vasoconstriction.
  • Cardiac arrest: provides immediate circulatory support to maintain perfusion during resuscitation.
  • Septic shock: increases systemic vascular resistance to counteract profound vasodilation.

How It Works

  • Noradrenaline tartrate binds directly to alpha‑1 adrenergic receptors on vascular smooth muscle, causing potent vasoconstriction and raising systemic vascular resistance. It also stimulates beta‑1 receptors in the heart, leading to increased heart rate and contractility, thereby enhancing cardiac output in acute circulatory collapse.

Side Effects

Adverse reactions may occur with intravenous noradrenaline administration.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Tachycardia: elevated heart rate due to beta‑1 stimulation.
  • Palpitations: sensation of rapid or irregular heartbeat.
  • Peripheral ischemia: reduced blood flow to extremities.
  • Nausea: occasional gastrointestinal discomfort.
  • Anxiety: heightened nervousness or restlessness.

Serious or Rare Side Effects

  • Arrhythmias: potentially life‑threatening rhythm disturbances.
  • Myocardial ischemia: reduced oxygen supply to heart muscle.
  • Severe hypertension: abrupt, dangerous rise in blood pressure.
  • Tissue necrosis: local injury at infusion site if extravasation occurs.

Precautions & Warnings

Clinicians should observe specific safety measures when using Noradrenalina Labesfal.

  • Monitoring: continuous blood pressure and cardiac rhythm monitoring is required.
  • Dose titration: adjust infusion rate based on hemodynamic response.
  • Extravasation risk: avoid infiltration; stop infusion immediately if leakage suspected.
  • Contraindications: avoid in patients with uncorrected pheochromocytoma or severe ventricular dysfunction.
  • Storage: Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Noradrenaline may interact with several agents, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Beta‑blockers: may blunt the desired increase in heart rate and contractility.
  • MAO inhibitors: can potentiate hypertensive effects.
  • Tricyclic antidepressants: increase risk of severe hypertension.

Moderate Interactions (Monitor Closely)

  • Vasodilators (e.g., nitroglycerin): may require higher noradrenaline doses.
  • Calcium channel blockers: can affect vascular tone and heart rate.
  • Diuretics: may influence intravascular volume and response to vasopressor therapy.

Frequently Asked Questions

Noradrenalina Labesfal is an intravenous vasopressor used in hospital settings to treat severe hypotension, support circulation during cardiac arrest, and improve vascular tone in patients with septic shock.

Noradrenaline tartrate acts as a direct agonist at alpha‑1 adrenergic receptors, causing vasoconstriction, and also stimulates beta‑1 receptors in the heart, increasing heart rate and contractility to raise blood pressure and cardiac output.

The dose of Noradrenalina Labesfal is individualized by the prescriber based on the patient’s hemodynamic status and response; clinicians titrate the infusion to achieve target blood pressure and perfusion goals.

Safety data for noradrenaline in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and under specialist supervision.

To order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Noradrenaline is the first‑line vasopressor for most forms of shock because of its potent alpha‑1 mediated vasoconstriction and modest beta‑1 activity. Compared with dopamine, it has a lower risk of tachyarrhythmias, and unlike phenylephrine, it also supports cardiac output.

The product must be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen. Before use, inspect the solution for particulate matter and ensure the vial is kept in its original packaging.

Noradrenalina Labesfal is given as an intravenous infusion, typically via a central venous catheter. The infusion rate is adjusted continuously based on real‑time blood pressure and cardiac monitoring.

Serious risks include severe hypertension, myocardial ischemia, life‑threatening arrhythmias, and peripheral tissue necrosis if the drug extravasates. Continuous hemodynamic monitoring is essential to detect and manage these complications promptly.

Patients with uncorrected pheochromocytoma, severe ventricular dysfunction, or known hypersensitivity to noradrenaline tartrate should not receive this medication, and its use should be avoided in those where the risks outweigh the benefits.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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