Product image of Noradrenalina Tartrato (Noradrenaline Tartrate) supplied by GNH India

Noradrenalina Tartrato

Active Ingredient:
Noradrenaline Tartrate
Origin:
EU

Noradrenalina Tartrato (Noradrenaline Tartrate)

Noradrenaline tartrate, the active ingredient in Noradrenalina Tartrato, is a vasopressor presented as an injection solution for intravenous use. It is employed to raise blood pressure and improve cardiac output in acute hypotensive states such as septic shock, cardiogenic shock and cardiac arrest.
GNH India supplies Noradrenalina Tartrato as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Laboratoire Aguettant

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Indications & Clinical Uses

Noradrenalina Tartrato is used as a potent vasopressor in critical care settings to support circulatory function.

  • Hypotension: restores arterial pressure and organ perfusion.
  • Septic shock: counteracts vasodilatory failure and improves hemodynamics.
  • Cardiogenic shock: enhances myocardial contractility and systemic vascular resistance.
  • Cardiac arrest: provides immediate pressor support during resuscitation efforts.

How It Works

  • Noradrenaline tartrate acts as an agonist at alpha‑1 and beta‑1 adrenergic receptors. Stimulation of alpha‑1 receptors produces peripheral vasoconstriction, raising systemic vascular resistance, while beta‑1 activation increases heart rate and myocardial contractility, together elevating cardiac output and arterial pressure in acute circulatory collapse.

Side Effects

Adverse reactions may occur with intravenous norepinephrine administration.

Common Side Effects

  • Tachycardia: increased heart rate due to beta‑1 stimulation.
  • Hypertension: excessive rise in blood pressure from alpha‑1 vasoconstriction.
  • Headache: secondary to elevated arterial pressure.
  • Nausea or vomiting: gastrointestinal discomfort.
  • Peripheral ischemia: reduced blood flow to extremities.

Serious or Rare Side Effects

  • Arrhythmias: potentially life‑threatening cardiac rhythm disturbances.
  • Myocardial ischemia: reduced coronary perfusion from intense vasoconstriction.
  • Tissue necrosis: extravasation causing local tissue injury.
  • Severe hypertension: risk of cerebrovascular events.
  • Pulmonary edema: fluid accumulation due to increased afterload.

Precautions & Warnings

Noradrenalina Tartrato requires careful monitoring and specific safety measures in clinical use.

  • Blood pressure monitoring: adjust infusion to maintain target MAP.
  • Cardiac function assessment: watch for tachyarrhythmias and ischemia.
  • Dose titration: start low and increase gradually based on response.
  • Caution in arrhythmia patients: avoid rapid dose escalations.
  • Extravasation risk: use central venous access when possible.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Noradrenaline may interact with several drug classes, influencing its pressor effect or safety profile.

Major Interactions (Avoid)

  • MAO inhibitors: can cause hypertensive crisis due to excess catecholamines.
  • Ergot alkaloids: risk of severe vasospasm and ischemia.
  • Other potent vasopressors: may lead to excessive hypertension.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may blunt beta‑1 mediated cardiac effects.
  • ACE inhibitors or ARBs: can attenuate blood pressure response.
  • Diuretics: may potentiate volume depletion and hypotension.

Frequently Asked Questions

Noradrenalina Tartrato is an injectable vasopressor used in emergency and intensive‑care settings to raise blood pressure and improve cardiac output in conditions such as severe hypotension, septic shock, cardiogenic shock and cardiac arrest.

The drug acts as an agonist at alpha‑1 receptors, causing peripheral vasoconstriction, and at beta‑1 receptors, increasing heart rate and contractility. This combined effect elevates systemic vascular resistance and cardiac output, helping to restore adequate organ perfusion.

The dosage is individualized and set by the treating physician based on the patient’s hemodynamic status, target blood pressure, and response to therapy. Infusion rates are titrated to achieve the desired circulatory support.

Safety data for noradrenaline in pregnancy and lactation are limited. It should only be used when the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by the prescribing clinician.

Enquiries are submitted via the product page at gnhindia.com, where you specify the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Noradrenaline is the first‑line vasopressor for most forms of shock because of its balanced alpha‑1 and beta‑1 activity. Compared with dopamine, it has a lower risk of tachyarrhythmias, and unlike phenylephrine, it also supports cardiac output through beta‑1 stimulation.

The product must be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Prior to use, inspect the solution for particulate matter and ensure the vial is within its expiry date.

It is given as an intravenous infusion, typically through a central venous catheter. The infusion is started at a low rate and titrated according to the patient’s blood pressure and clinical response, with continuous hemodynamic monitoring.

Serious risks include severe hypertension, arrhythmias, myocardial ischemia, peripheral ischemia leading to tissue necrosis, and extravasation injury. Prompt recognition and management of these events are essential during therapy.

Patients with known hypersensitivity to noradrenaline or any excipients, those with uncontrolled severe hypertension, or individuals at high risk for peripheral ischemia should not receive the drug unless benefits outweigh the risks and close monitoring is ensured.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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