Product image of Noradrenalina Tartrato Hameln (Noradrenaline Tartrate) supplied by GNH India

Noradrenalina Tartrato Hameln

Active Ingredient:
Noradrenaline Tartrate
Origin:
EU

Noradrenalina Tartrato Hameln (Noradrenaline Tartrate)

Noradrenaline tartrate, the active ingredient in Noradrenalina Tartrato Hameln, is a sympathomimetic amine presented as a sterile injectable solution for intravenous use. It acts as a vasopressor to raise blood pressure in patients with hypotension or septic shock and is administered under medical supervision in acute care settings.

GNH India supplies Noradrenalina Tartrato Hameln as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide. Our distribution network ensures timely delivery and regulatory compliance across EU and global markets.

Manufacturer / TM Owner

Hameln Pharma Gmbh

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Indications & Clinical Uses

Noradrenaline tartrate is used as a vasopressor acting on the sympathetic adrenergic system to treat severe hypotension.

  • Hypotension: restores adequate arterial pressure in acute low‑blood‑pressure states.
  • Septic shock: supports circulatory function when sepsis causes profound vasodilation.
  • Cardiogenic shock: helps maintain perfusion pressure when cardiac output is insufficient.

How It Works

  • Noradrenaline tartrate binds directly to alpha‑1 adrenergic receptors on vascular smooth muscle, triggering vasoconstriction and increasing systemic vascular resistance. The resulting rise in arterial pressure improves organ perfusion. It also stimulates beta‑1 receptors modestly, enhancing cardiac contractility, which contributes to its overall pressor effect in critically ill patients.

Side Effects

Noradrenaline tartrate may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Tachycardia: rapid heart rate due to beta‑1 stimulation.
  • Headache: result of increased vascular tone.
  • Anxiety or restlessness: central nervous system activation.
  • Nausea or vomiting: gastrointestinal irritation.
  • Peripheral ischemia: reduced blood flow to extremities.
  • Arrhythmias: irregular heart rhythms.

Serious or Rare Side Effects

  • Severe hypertension: excessive rise in blood pressure.
  • Myocardial infarction: heart attack risk in vulnerable patients.
  • Tissue necrosis at injection site: extravasation injury.
  • Pulmonary edema: fluid accumulation in lungs.
  • Cardiac arrest: sudden loss of heart function.
  • Severe arrhythmias: life‑threatening rhythm disturbances.

Precautions & Warnings

When using Noradrenaline tartrate, clinicians should observe several safety measures.

  • Monitor blood pressure: adjust infusion to maintain target MAP.
  • Assess cardiac rhythm: watch for tachyarrhythmias and ischemia.
  • Avoid extravasation: prefer central venous access and inspect infusion site frequently.
  • Use with caution in coronary artery disease: risk of myocardial ischemia.
  • Limit use in severe peripheral vascular disease: risk of limb ischemia.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Noradrenaline tartrate can interact with several drug classes, requiring vigilance.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis.
  • Tricyclic antidepressants: additive pressor effect.
  • Beta‑blockers: may blunt desired increase in cardiac output.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: may enhance hypotensive episodes when infusion is tapered.
  • Calcium channel blockers: potential for additive vasodilation.
  • Diuretics: may affect intravascular volume and response.

Frequently Asked Questions

Noradrenalina Tartrato Hameln contains noradrenaline tartrate, a vasopressor used in hospitals to raise blood pressure in patients with acute hypotension, septic shock, or cardiogenic shock when rapid circulatory support is required.

The drug acts as a direct agonist at alpha‑1 adrenergic receptors, causing blood‑vessel constriction and increased systemic vascular resistance. It also modestly stimulates beta‑1 receptors, enhancing heart contractility, together producing a rapid rise in arterial pressure.

The dose is individualized by the treating physician based on the patient’s hemodynamic status, target blood‑pressure goals, and response to therapy. Dosing is typically expressed as a continuous intravenous infusion rate and adjusted in real time.

Safety data in pregnancy and lactation are limited. The drug should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and it is prescribed by a specialist familiar with its profile.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Noradrenaline is the first‑line vasopressor for most forms of shock because of its potent alpha‑1 activity and relatively predictable effect on blood pressure. Compared with dopamine or phenylephrine, it offers stronger vasoconstriction with less tachyarrhythmia risk, making it preferred in septic shock.

The injectable solution should be stored at 2‑8 °C, protected from light, and kept in its original container. Do not freeze or shake the vial. Once removed from refrigeration, use within the time frame specified by the manufacturer.

It is given intravenously, usually via a calibrated infusion pump. Administration is performed in a monitored setting such as an intensive‑care unit, with continuous blood‑pressure and cardiac‑rhythm monitoring to allow rapid dose adjustments.

Clinicians should be alert for severe hypertension, myocardial ischemia or infarction, arrhythmias, tissue necrosis from extravasation, and, in rare cases, pulmonary edema or cardiac arrest. Prompt recognition and dose modification are essential to mitigate these risks.

Patients with known hypersensitivity to noradrenaline or any excipients, those with uncontrolled severe peripheral vascular disease, or individuals in whom vasoconstriction could worsen tissue perfusion should not be treated with this drug.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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