Product image of Noradrenalina Tartrato (Norepinefrina) Aguettant (Noradrenaline Tartrate) supplied by GNH India

Noradrenalina Tartrato (Norepinefrina) Aguettant

Active Ingredient:
Noradrenaline Tartrate
Origin:
EU

Noradrenalina Tartrato (Norepinefrina) Aguettant (Noradrenaline Tartrate)

Noradrenaline Tartrate, the active ingredient in Noradrenalina Tartrato (Aguettant), is a sympathomimetic (catecholamine) vasopressor presented as a solution for injection for intravenous use. It treats hypotension, septic shock, cardiogenic shock and cardiac arrest in hospitalized patients.

GNH India supplies Noradrenalina Tartrato (Aguettant) as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratoire Aguettant

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Indications & Clinical Uses

  • Noradrenaline Tartrate is used in acute cardiovascular emergencies to restore vascular tone and cardiac output.
  • Hypotension: raises blood pressure in patients with acute low‑pressure states.
  • Septic shock: increases systemic vascular resistance in septic shock.
  • Cardiogenic shock: enhances myocardial contractility and perfusion.
  • Cardiac arrest: supports circulation during resuscitation when combined with other emergency measures.

How It Works

  • Noradrenaline Tartrate acts as an agonist at α1‑adrenergic receptors, causing peripheral vasoconstriction, and at β1‑adrenergic receptors, increasing heart‑muscle contractility and rate. The combined α and β stimulation raises systemic vascular resistance and cardiac output, thereby improving tissue perfusion in states of circulatory failure.

Side Effects

Adverse reactions may occur with any vasopressor therapy.

Common Side Effects

  • Tachycardia
  • Hypertension
  • Arrhythmias
  • Headache
  • Nausea
  • Peripheral ischemia

Serious or Rare Side Effects

  • Myocardial ischemia
  • Severe hypertension
  • Tissue necrosis at injection site
  • Pulmonary edema
  • Life‑threatening arrhythmias
  • Anaphylactic reaction

Precautions & Warnings

Noradrenaline Tartrate requires careful monitoring in critical care settings.

  • Blood pressure monitoring: continuous arterial pressure measurement is essential.
  • Cardiac disease: use with caution in patients with coronary artery disease or recent myocardial infarction.
  • Arrhythmias: avoid rapid infusion in patients with known arrhythmias.
  • Pheochromocytoma: contraindicated due to risk of hypertensive crisis.
  • Renal/hepatic impairment: dose adjustments may be needed.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Noradrenaline Tartrate can interact with several drug classes.

Major Interactions (Avoid)

  • MAO inhibitors: risk of severe hypertensive crisis.
  • Beta‑blockers: may blunt the intended cardiovascular response.
  • Tricyclic antidepressants: additive catecholamine effects.
  • Local anesthetics: increased cardiotoxicity risk.
  • Vasodilators: may cause unpredictable blood pressure changes.

Moderate Interactions (Monitor Closely)

  • Calcium channel blockers: may enhance vasoconstrictive effects.
  • Diuretics: potential for volume depletion.
  • ACE inhibitors: possible additive hypotensive effect after tapering.
  • Other antihypertensives: monitor for excessive blood pressure rise.
  • Antifungal agents (azoles): may alter metabolism of catecholamines.

Frequently Asked Questions

Noradrenalina Tartrato (Noradrenaline Tartrate) is used in hospitals to treat severe hypotension, septic shock, cardiogenic shock and cardiac arrest. It works as a vasopressor to raise blood pressure and improve heart function during acute circulatory failure.

The drug activates α1‑adrenergic receptors, causing blood vessels to constrict, and β1‑adrenergic receptors, increasing heart‑muscle contractility and rate. This dual action raises systemic vascular resistance and cardiac output, restoring adequate tissue perfusion.

The dose is determined by the prescribing clinician based on the patient’s hemodynamic status, response, and clinical setting. Dosing is individualized and administered intravenously under continuous monitoring.

Safety data are limited; the product is classified as pregnancy category unknown. It should only be used during pregnancy or lactation if the potential benefit justifies the potential risk, and it must be prescribed by a specialist.

Submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Noradrenaline Tartrate is a first‑line catecholamine vasopressor, offering strong α1‑mediated vasoconstriction with modest β1 activity. Comparedافة other agents such as dopamine or phenylephrine, it provides a balanced increase in vascular tone and cardiac output, making it preferred in many shock protocols.

The product must be stored at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use and discard any solution that appears discolored or contains particles.

It is supplied as a sterile solution for injection and is given intravenously, usually via a central line or a peripheral IV with a controlled infusion pump. Administration is performed by trained healthcare professionals under continuous hemodynamic monitoring.

Serious risks include severe hypertension, myocardial ischemia, life‑threatening arrhythmias, tissue necrosis at the injection site, and anaphylactic reactions. Continuous blood pressure and cardiac monitoring are essential to detect and manage these events promptly.

Patients with known hypersensitivity to noradrenaline or any component of the formulation, those with pheochromocytoma, or individuals in whom uncontrolled hypertension would be dangerous should not receive this medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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