Product image of Noradrenalina Tartrato S.A.L.F. (Noradrenaline Tartrate) supplied by GNH India

Noradrenalina Tartrato S.A.L.F.

Active Ingredient:
Noradrenaline Tartrate
Origin:
EU

Noradrenalina Tartrato S.A.L.F. (Noradrenaline Tartrate)

Noradrenaline tartrate, the active ingredient in Noradrenalina Tartrato S.A.L.F., is a catecholamine sympathomimetic presented as an injection solution for intravenous use. It is employed to raise blood pressure and support cardiac output in acute hypotensive states, septic shock, cardiac arrest, and bradycardia.

GNH India supplies Noradrenalina Tartrato S.A.L.F. as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

S.A.L.F. Spa Laboratorio Farmacologico

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Indications & Clinical Uses

  • Noradrenaline tartrate acts on the adrenergic system to restore vascular tone and cardiac performance in critical care settings.
  • Acute hypotension: restores vascular tone and raises systemic blood pressure.
  • Septic shock: improves perfusion pressure and organ blood flow.
  • Cardiac arrest: enhances coronary and cerebral perfusion during resuscitation.
  • Bradycardia: increases heart rate and cardiac output when intrinsic pacing is insufficient.

How It Works

  • Noradrenaline tartrate is a direct agonist at alpha‑1 and beta‑1 adrenergic receptors. Stimulation of alpha‑1 receptors on vascular smooth muscle produces vasoconstriction, increasing systemic vascular resistance. Activation of beta‑1 receptors on cardiac myocytes enhances contractility and heart rate, together raising arterial pressure and cardiac output in acute circulatory failure.

Side Effects

Adverse reactions may occur with intravenous administration of noradrenaline tartrate.

Common Side Effects

  • Tachycardia: rapid increase in heart rate.
  • Hypertension: excessive rise in blood pressure.
  • Arrhythmia: irregular heart rhythm.
  • Headache: pressure sensation in the head.
  • Nausea: feeling of sickness.
  • Peripheral ischemia: reduced blood flow to extremities.

Serious or Rare Side Effects

  • Myocardial ischemia: reduced blood supply to heart muscle.
  • Severe arrhythmias: life‑threatening rhythm disturbances.
  • Tissue necrosis at injection site: local tissue death.
  • Pulmonary edema: fluid accumulation in lungs.
  • Extreme hypertension: dangerously high blood pressure.
  • Cardiac arrest: sudden loss of heart function.

Precautions & Warnings

  • Noradrenaline tartrate requires careful monitoring and specific safety measures.
  • Cardiovascular monitoring: continuously observe blood pressure and heart rate during infusion.
  • Dose titration: adjust infusion rate based on real‑time hemodynamic response.
  • Underlying cardiac disease: use with caution in patients with ischemic heart disease.
  • Electrolyte balance: correct severe hypokalemia or hypomagnesemia before administration.
  • Drug interactions: avoid concurrent use with monoamine oxidase inhibitors.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Noradrenaline tartrate can interact with several drug classes, influencing its safety and efficacy.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis.
  • Beta‑blockers: may blunt desired cardiac effects.
  • Tricyclic antidepressants: increase risk of arrhythmia.
  • Ergot alkaloids: potent vasoconstriction leading to ischemia.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: additive hypotensive effect after discontinuation.
  • Diuretics: may exacerbate electrolyte disturbances.
  • Calcium channel blockers: potential for excessive vasodilation after tapering.

Frequently Asked Questions

Noradrenalina Tartrato S.A.L.F. contains noradrenaline tartrate, a vasopressor used in emergency and intensive‑care settings to treat acute hypotension, septic shock, cardiac arrest, and severe bradycardia by increasing vascular tone and cardiac output.

The drug acts as a direct agonist at alpha‑1 receptors, causing vasoconstriction, and at beta‑1 receptors, enhancing heart contractility and rate. This dual action raises systemic blood pressure and improves organ perfusion during circulatory collapse.

Dosing is individualized and must be prescribed by a qualified clinician. The prescriber determines the infusion concentration and titration rate based on the patient’s hemodynamic status and response to therapy.

Safety data for pregnancy and lactation are limited. The drug should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and it must be prescribed by a specialist.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Noradrenaline tartrate is considered a first‑line vasopressor because of its potent alpha‑1 mediated vasoconstriction combined with modest beta‑1 activity. Compared with agents such as dopamine or phenylephrine, it provides more predictable blood‑pressure support with fewer tachyarrhythmic effects, making it preferred in septic shock protocols.

The product must be stored refrigerated at 2‑8 °C, protected from light, and should never be frozen or shaken. Use aseptic technique for preparation, and keep the solution in its original container until administration.

Noradrenaline tartrate is supplied as an injectable solution for intravenous infusion. It is typically diluted in a compatible carrier fluid and administered via a controlled infusion pump, allowing precise titration to the desired hemodynamic target.

Clinicians should monitor for severe hypertension, myocardial ischemia, life‑threatening arrhythmias, and peripheral tissue necrosis at the infusion site. Early detection of these events requires continuous blood‑pressure and cardiac‑monitoring throughout the infusion.

Patients with known hypersensitivity to noradrenaline or any component of the formulation should avoid the drug. Caution is also advised in individuals with severe peripheral vascular disease, uncontrolled tachyarrhythmias, or those receiving MAO inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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