Product image of Noradrenaline Aguettant (Noradrenaline Tartrate) supplied by GNH India

Noradrenaline Aguettant

Active Ingredient:
Noradrenaline Tartrate
Origin:
EU

Noradrenaline Aguettant (Noradrenaline Tartrate)

Noradrenaline tartrate, the active ingredient in Noradrenaline Aguettant, is a sympathomimetic amine presented as an injectable solution for intravenous use. It acts rapidly to increase vascular tone and cardiac output, making it essential in the management of severe hypotension, septic shock, and cardiac arrest.

GNH India supplies Noradrenaline Aguettant as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide. The company adheres to EU quality standards and provides reliable logistics for critical care medicines across global markets.

Manufacturer / TM Owner

Laboratoire Aguettant

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Indications & Clinical Uses

Noradrenaline Aguettant is employed as a potent vasopressor to treat acute, life‑threatening states of low systemic vascular resistance and blood pressure.

  • Hypotension: restores arterial pressure to maintain organ perfusion.
  • Septic shock: counteracts vasodilatory failure to improve hemodynamics.
  • Cardiac arrest: supports coronary and cerebral perfusion during resuscitation.
  • Vasodilatory shock: provides vasoconstriction to stabilize systemic blood pressure.

How It Works

  • Noradrenaline tartrate acts primarily as an α1‑adrenergic receptor agonist, inducing smooth‑muscle contraction in arterioles and veins, which raises systemic vascular resistance and arterial pressure. It also stimulates β1‑adrenergic receptors in the heart, modestly increasing heart rate and contractility, thereby enhancing cardiac output. The combined α‑ and β‑adrenergic activity rapidly restores perfusion to vital organs in shock states.

Side Effects

Noradrenaline Aguettant may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Tachycardia: increased heart rate.
  • Nausea: gastrointestinal discomfort.
  • Peripheral vasoconstriction causing cold extremities: reduced skin temperature.

Serious or Rare Side Effects

  • Severe hypertension: dangerously high blood pressure.
  • Cardiac ischemia: reduced coronary blood flow.
  • Tissue necrosis at infusion site: severe local damage if extravasation occurs.
  • Pulmonary edema: fluid accumulation in lungs leading to respiratory compromise.

Precautions & Warnings

When using Noradrenaline Aguettant, careful clinical monitoring and adherence to safety measures are essential.

  • Dose titration: adjust infusion rate to target blood pressure.
  • Cardiac monitoring: continuously observe heart rhythm and rate.
  • Peripheral perfusion: assess limb circulation during infusion.
  • Contraindications: avoid in patients with uncontrolled hypertension.
  • Drug interactions: review concomitant vasodilators and MAO inhibitors.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Noradrenaline Aguettant can interact with several drug classes; awareness of these interactions helps prevent adverse outcomes.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis.
  • Tricyclic antidepressants: additive vasoconstriction.
  • Direct‑acting vasodilators (e.g., nitroprusside): antagonistic effect.

Moderate Interactions (Monitor Closely)

  • β‑blockers: may blunt β1‑mediated cardiac effects.
  • Calcium channel blockers: potential additive cardiovascular effects.
  • Diuretics: may exacerbate volume depletion and hypotension.

Frequently Asked Questions

Noradrenaline Aguettant is a prescription vasopressor used in acute care settings to raise blood pressure and improve organ perfusion in patients experiencing severe hypotension, septic shock, or cardiac arrest.

Noradrenaline tartrate stimulates α1‑adrenergic receptors causing vasoconstriction, which increases systemic vascular resistance. It also activates β1‑adrenergic receptors in the heart, modestly raising heart rate and contractility, together restoring circulatory stability.

The dosage and infusion rate of Noradrenaline Aguettant are determined by the prescribing clinician based on the patient’s hemodynamic status, target blood pressure, and response to therapy. No fixed regimen is provided here.

Safety data for noradrenaline in pregnancy and lactation are limited. Use is generally reserved for situations where the potential benefit outweighs any possible risk to the fetus or infant, and only under specialist supervision.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Noradrenaline is considered the first‑line vasopressor for most forms of distributive shock because of its strong α1‑mediated vasoconstriction and modest β1 activity. Compared with agents like dopamine or phenylephrine, it offers more predictable blood pressure control with fewer tachyarrhythmic effects.

The product should be stored at 2‑8 °C, protected from light, and must not be frozen or shaken. Use aseptic technique when preparing the intravenous solution, and discard any solution that has been left at room temperature beyond the recommended time.

Noradrenaline Aguettant is given by intravenous infusion, typically via a central venous catheter. The infusion is started at a low rate and titrated according to the patient’s blood pressure response, with continuous hemodynamic monitoring.

Serious risks include severe hypertension, cardiac ischemia, tissue necrosis at the infusion site due to extravasation, and pulmonary edema. Prompt recognition and management of these events are critical to patient safety.

Patients with uncontrolled hypertension, known hypersensitivity to noradrenaline or its excipients, and those in whom vasoconstriction could worsen tissue perfusion (e.g., severe peripheral vascular disease) should not receive this medication unless benefits clearly outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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