Product image of Noradrenaline Kabi (Noradrenaline Tartrate) supplied by GNH India

Noradrenaline Kabi

Active Ingredient:
Noradrenaline Tartrate
Origin:
EU

Noradrenaline Kabi (Noradrenaline Tartrate)

Noradrenaline tartrate, the active ingredient in Noradrenaline Kabi, is a vasopressor presented as an injectable solution for intravenous use. It raises blood pressure and supports cardiac output in patients with severe hypotension, septic shock, or cardiac arrest. It is indicated for emergency management of circulatory failure and is manufactured according to EU GMP standards.

GNH India supplies Noradrenaline Kabi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide. The company provides temperature‑controlled logistics and complies with global regulatory requirements, enabling reliable delivery to intensive care units and emergency departments across continents.

Manufacturer / TM Owner

Fresenius Kabi Hellas Single Member S.A.

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Indications & Clinical Uses

Noradrenaline Kabi is a vasopressor used in critical care to restore vascular tone and improve perfusion.

  • Hypotension: increases systemic vascular resistance to raise arterial pressure in patients with acute low blood pressure.
  • Septic shock: counteracts vasodilatory shock by constricting blood vessels and supporting organ perfusion.
  • Cardiac arrest: enhances coronary and cerebral blood flow during resuscitation efforts.

How It Works

  • Noradrenaline tartrate acts as an agonist at α1‑adrenergic receptors, producing potent vasoconstriction that elevates systemic vascular resistance and arterial pressure. It also stimulates β1‑adrenergic receptors in the heart, increasing myocardial contractility and cardiac output. The combined α‑ and β‑adrenergic activity restores hemodynamic stability in states of profound circulatory collapse. Additionally, norepinephrine reduces venous capacitance, shifting blood toward the central circulation, and may modestly increase pulmonary vascular resistance.

Side Effects

Noradrenaline Kabi may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Headache
  • Tachycardia
  • Peripheral ischemia
  • Nausea
  • Sweating

Serious or Rare Side Effects

  • Myocardial ischemia
  • Severe hypertension
  • Tissue necrosis at infusion site
  • Anaphylactic reaction

Precautions & Warnings

When using Noradrenaline Kabi, careful monitoring and appropriate handling are essential.

  • Blood pressure monitoring: continuous arterial pressure measurement is required during infusion.
  • Dose titration: adjust infusion rate to achieve target mean arterial pressure.
  • Cardiac function assessment: evaluate for underlying ischemia before initiating therapy.
  • Contraindication in uncontrolled hypertension: avoid rapid high‑dose bolus in patients with severe hypertension.
  • Peripheral vascular disease caution: monitor for limb ischemia and consider alternative agents.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Noradrenaline Kabi can interact with several drug classes; awareness of these interactions helps optimize therapy.

Major Interactions (Avoid)

  • MAO inhibitors: concurrent use may cause hypertensive crisis.
  • Tricyclic antidepressants: increased risk of severe hypertension.
  • Ergot alkaloids: additive vasoconstriction leading to ischemia.

Moderate Interactions (Monitor Closely)

  • Vasodilators (e.g., nitroglycerin): may reduce efficacy, requiring higher norepinephrine doses.
  • Beta‑blockers: can blunt β1‑mediated increase in cardiac output.
  • ACE inhibitors: may enhance hypotensive episodes during abrupt withdrawal.

Frequently Asked Questions

Noradrenaline Kabi is used in emergency and intensive‑care settings to treat severe hypotension, septic shock, and cardiac arrest. By increasing vascular tone and cardiac output, it helps restore adequate blood pressure and organ perfusion in patients with life‑threatening circulatory failure.

Noradrenaline tartrate acts as an agonist at α1‑adrenergic receptors, causing vasoconstriction that raises systemic vascular resistance and arterial pressure. It also stimulates β1‑adrenergic receptors in the heart, enhancing contractility and cardiac output, thereby stabilising haemodynamics during shock states.

The dose of Noradrenaline Kabi is individualized and set by the treating physician based on the patient’s haemodynamic status, target blood pressure, and response to therapy. Dosing is typically administered as a continuous intravenous infusion that is titrated to achieve the desired mean arterial pressure.

Safety data for Noradrenaline Kabi in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order Noradrenaline Kabi, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain logistics if needed) and any required import documentation.

Noradrenaline Kabi is often preferred over dopamine because it provides more predictable α‑adrenergic vasoconstriction with less tachyarrhythmia. Compared with epinephrine, it has a stronger α‑effect and a weaker β‑effect, making it useful when raising blood pressure is the primary goal while minimizing excessive heart rate increase.

Noradrenaline Kabi must be stored at 2‑8 °C in a refrigerator, protected from light. The product should not be frozen or shaken. During transport, maintain the cold‑chain conditions and keep the vial in its original packaging to preserve stability.

Noradrenaline Kabi is administered intravenously, usually via a calibrated infusion pump. The drug is diluted in a compatible carrier solution and infused continuously, with the rate adjusted according to the patient’s blood pressure response and clinical goals.

Serious risks include severe hypertension, myocardial ischemia, and tissue necrosis at the infusion site due to intense vasoconstriction. Clinicians should monitor cardiac rhythm, arterial pressure, and peripheral perfusion closely, and be prepared to adjust or discontinue therapy if these complications arise.

Noradrenaline Kabi is contraindicated in patients with known hypersensitivity to noradrenaline or any of its excipients, and it should be avoided in individuals with uncontrolled severe hypertension or peripheral vascular disease where further vasoconstriction could cause critical limb ischemia.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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